Email:yuhuijiang@ecust.edu.cn

個(gè)人簡(jiǎn)介

   蔣玉輝，中共黨員，教授，博士生導(dǎo)師，入選國(guó)家級(jí)高層次青年人才、上海市青年科技啟明星計(jì)劃、上海市青年拔尖人才，任中華醫(yī)學(xué)會(huì)消化病學(xué)分會(huì)第十一屆委員會(huì)胰腺病學(xué)組委員；2006年6月獲湖南師范大學(xué)生命科學(xué)學(xué)院學(xué)士學(xué)位，2011年7月獲中科院上海生科院營(yíng)養(yǎng)科學(xué)研究所博士學(xué)位，2011年9月至2015年6月在美國(guó)得州大學(xué)MD安德森癌癥中心從事博士后研究；工作經(jīng)歷上，2015年7月至2019年7月任上海交通大學(xué)附屬第一人民醫(yī)院研究員，2019年12月至2024年10月任上海交通大學(xué)醫(yī)學(xué)院附屬仁濟(jì)醫(yī)院研究員，2024年11月起任華東理工大學(xué)藥學(xué)院教授。

    本課題組研究聚焦于細(xì)胞代謝網(wǎng)絡(luò)調(diào)控與藥理學(xué)，圍繞代謝酶調(diào)控生理活動(dòng)進(jìn)而影響腫瘤生長(zhǎng)、代謝酶與生長(zhǎng)因子信號(hào)互作等關(guān)鍵科學(xué)問題展開，研究關(guān)鍵詞包括代謝調(diào)控、代謝檢測(cè)、代謝酶等。以通訊作者在Nature Cell Biology、Nature Structural & Molecular Biology、Nature Metabolism、Molecular Cell、Nature Communications、Cell Reports等權(quán)威期刊發(fā)表多篇論文，獲國(guó)內(nèi)發(fā)明專利授權(quán)2項(xiàng)，主持國(guó)家重點(diǎn)研發(fā)計(jì)劃專項(xiàng)課題、國(guó)家自然科學(xué)基金聯(lián)合基金項(xiàng)目（重點(diǎn)支持項(xiàng)目）及面上項(xiàng)目，獲中國(guó)藥學(xué)會(huì)科學(xué)技術(shù)獎(jiǎng)一等獎(jiǎng)、上海藥學(xué)科技獎(jiǎng)一等獎(jiǎng)。

主要研究方向

  細(xì)胞代謝網(wǎng)絡(luò)調(diào)控與藥理學(xué)

獲獎(jiǎng)情況

1. 2025年 中國(guó)藥學(xué)會(huì)科學(xué)技術(shù)獎(jiǎng)一等獎(jiǎng)

2. 2023年 上海藥學(xué)科技獎(jiǎng)一等獎(jiǎng)

4. 2016年 上海高校青年東方學(xué)者

5. 2016年 上海市青年科技啟明星計(jì)劃

6. 2015年 上海市青年拔尖人才

7. 2015年 USCACA-AFCR Scholar Awardees

代表性論著（*共同通訊作者）

1. Bei Zhou; Qin Zhao; Guofang Hou; Jing He; Nannan Sha; Ke Zheng; Hongyu Peng; Wang Wang; Yue Zhou; Tao Chen; Yuhui Jiang; IMPDH2 dephosphorylation under FGFR signaling es S-phase progression and tumor growth, Cell Reports, 2025, 44(1): 115116.

2. Nannan Sha; Bei Zhou; Guofang Hou; Zhifeng Xi; Wang Wang; Man Yan; Jing He; Yue Zhou; Qiang Xia; Yuhui Jiang*; Qin Zhao; The protection of UCK2 protein stability by GART maintains pyrimidine salvage synthesis for HCC growth under glucose limitation, Oncogene, 2025, 44(16):1078-1092.

3. Jing He; Aoxue Wang; Qin Zhao; Yejun Zou; Zhuo Zhang; Nannan Sha; Guofang Hou; Bei Zhou; Yi Yang; Tao Chen; Yuzheng Zhao; Yuhui Jiang*; RNAi screens identify HES4 as a regulator of redox balance supporting pyrimidine synthesis and tumor growth, Nature Structural & Molecular Biology, 2024, 31(9): 1413-1425.

4. Yuzheng Zhao; Yuhui Jiang*; HES4 controls redox balance and supports pyrimidine synthesis and tumor growth, Nature Structural & Molecular Biology, 2024, 31(9): 1315-1316.

5. Ke Zheng; Nannan Sha; Guofang Hou; Zhuyun Leng; Qin Zhao; Li Zhang; Lingnan He; Meidong Xu; Yuhui Jiang*; Tao Chen; IGF1R-phosphorylated PYCR1 facilitates ELK4 transcriptional activity and sustains tumor growth under hypoxia, Nature Communications, 2023, 14(1): 6117.

6. Shupei Wei; Qin Zhao; Ke Zheng; Peiying Liu; Nannan Sha; Yingzi Li; Chunmin Ma; Jingjie Li; Lingang Zhuo; Guanxin Liu; Wenhua Liang; Yuhui Jiang*; Tao Chen; Nanshan Zhong; GFAT1-linked TAB1 glutamylation sustains p38 MAPK activation and es lung cancer cell survival under glucose starvation, Cell Discovery, 2022, 8(1): 77.

7. Chunmin Ma; Ke Zheng; Kun Jiang; Qin Zhao; Nannan Sha; Wang Wang; Man Yan; Tao Chen; Yuzheng Zhao; Yuhui Jiang*; The alternative activity of nuclear PHGDH contributes to tumour growth under nutrient stress, Nature Metabolism, 2021, 3(10): 1357-1371 .

8. Qin Zhao; Ke Zheng; Chunmin Ma; Jingjie Li; Lingang Zhuo; Wenhua Huang; Tao Chen; Yuhui Jiang*; PTPS facilitates compartmentalized LTBP1 S-nitrosylation and es tumor growth under hypoxia, Molecular Cell, 2020, 77(1): 95-107.

9.Tao Chen; Ting Wang; Wenhua Liang; Qin Zhao; Qiujing Yu; Chun-Min Ma; Lingang Zhuo; Dong Guo; Ke Zheng; Chengzhi Zhou; Shupei Wei; Wenhua Huang; Juhong Jiang; Jing Liu; Shiyue Li; Jianxing He; Yuhui Jiang*; Nanshan Zhong; PAK4 phosphorylates fumarase and blocks TGFβ-induced cell growth arrest in lung cancer cells, Cancer Research, 2019, 79(7): 1383-1397.

10. Jingjie Li; Bin Hu; Ting Wang; Wenhua Huang; Chunmin Ma; Qin Zhao; Lingang Zhuo; Tao Zhang; Yuhui Jiang; C-Src confers resistance to mitotic stress through inhibition DMAP1/Bub3 complex formation in pancreatic cancer, Molecular Cancer, 2018, 17(1): 174.

11. Ting Wang; Qiujing Yu; Jingjie Li; Bin Hu; Qin Zhao; Chunmin Ma; Wenhua Huang; Lingang Zhuo; Houqin Fang; Lujian Liao; Y. Eugene Chin; Yuhui Jiang*; O-GlcNAcylation of fumarase maintains tumour growth under glucose deficiency, Nature Cell Biology, 2017, 19(7): 833- 843.

12. Tao Chen; Jingjie Li; Meidong Xu; Qin Zhao; Yingyong Hou; Liqing Yao; Yunshi Zhong; Ping Chieh Chou; Wei Zhang; Pinghong Zhou; Yuhui Jiang*; PKCε phosphorylates MIIP and es colorectal cancer metastasis through inhibition of RelA deacetylation, Nature Communications, 2017, 8(1): 939.

13. Yuhui Jiang; Xu Qian; Jianfeng Shen; Yugang Wang; Xinjian Li; Rui Liu; Yan Xia; Qianming Chen; Guang Peng; Shiaw-Yih Lin; Zhimin Lu; Local generation of fumarate es DNA repair through inhibition of histone H3 demethylation, Nature Cell Biology, 2015, 17(9): 1158- 1168.

14. Yuhui Jiang; Xinjian Li; Weiwei Yang; David H. Hawke; Yanhua Zheng; Yan Xia; Kenneth Aldape; Chongyang Wei; Fang Guo; Yan Chen; Zhimin Lu; PKM2 regulates chromosome segregation and mitosis progression of tumor cells, Molecular Cell, 2014, 53(1): 75-87.

15. Yuhui Jiang; Yugang Wang; Ting Wang; David H. Hawke; Yanhua Zheng; Xinjian Li; Qin Zhou; Sadhan Majumder; Erfei Bi; David X. Liu; Suyun Huang; Zhimin Lu; PKM2 phosphorylates MLC2 and regulates cytokinesis of tumour cells, Nature Communications, 2014, 5: 5566.