學(xué)碩:植物保護(hù)(090400)
研究方向
綠色農(nóng)藥創(chuàng)制;AI輔助的農(nóng)藥分子設(shè)計(jì)
教育背景
1. 2019年09月-2022年12月,華東理工大學(xué),農(nóng)藥學(xué),博士,導(dǎo)師:程家高 教授,Peter Maienfisch 教授
2. 2016年09月-2019年06月,華東理工大學(xué),藥學(xué),碩士,導(dǎo)師:程家高 教授
3. 2012年09月-2016年06月,青島科技大學(xué),藥物制劑,學(xué)士
工作經(jīng)歷
1. 2025年01月-至今,華東理工大學(xué),藥學(xué)院,特聘副研究員,碩士生導(dǎo)師
2. 2023年01月-2024年12月,華東理工大學(xué),藥學(xué)院,博士后,合作導(dǎo)師:錢旭紅 教授
榮譽(yù)獎(jiǎng)勵(lì)
1. 國家資助博士后研究人員計(jì)劃,2023
2. 上海市“超級(jí)博士后”激勵(lì)計(jì)劃,2023
3. 上海市優(yōu)秀畢業(yè)生,2023
主持科研項(xiàng)目
1. 國家自然科學(xué)基金面上項(xiàng)目(22577029),2026年1月-2029年12月
2. 國家自然科學(xué)基金青年基金(22307039),2024年1月-2026年12月
3. 中國博士后科學(xué)基金面上項(xiàng)目(2023M731089),2023年7月-2024年12月
4. 上海市農(nóng)業(yè)科技創(chuàng)新春蕾項(xiàng)目(滬農(nóng)科T2024302),2024年11月-2027年10月
5. 上海市教育委員會(huì)“AI賦能科研計(jì)劃”,2025年1月-2026年12月
發(fā)表論文(#為共同一作)
1. Dongxu Zhang#, Cong Zhou#, Suzhen Qi, Huihui Zhang, Xusheng Shao, Xiaoyong Xu, Jiagao Cheng, Zewen Liu, Zhong Li, Wu-Lin Yang, Discovery of novel neonicotinoids with conjugated diene enabled by cascade allylation/isomerization synthetic methodology. J. Agric. Food Chem. 2025, 73, 2784–2792.(一區(qū)TOP)
2. Cong Zhou#, Yijin Kong#, Huihui Zhang, Na Zhai, Zhong Li, Xuhong Qian, Zewen Liu*, and Jiagao Cheng* Computational modeling-oriented substructure splicing application in the identification of thiazolidine derivatives as potential low honeybee toxic neonicotinoids J. Agric. Food Chem. 2024, 72, 11968–11979. (一區(qū)TOP)
3. Liangliang Cheng#, Cong Zhou#, Qinglong Yuan, Letian Zhang, Xusheng Shao, Xiaoyong Xu, Zhong Li, Jiagao Cheng* 3D-QSAR model-oriented optimization of Pyrazole β-Ketonitrile derivatives with diphenyl ether moiety as novel potent succinate dehydrogenase inhibitors. Pest Manag. Sci., 2024, 80, 5299–5306.(一區(qū)TOP)
4. Yijin Kong#, Cong Zhou#, Du Tan, Xiaoyong Xu, Zhong Li, and Jiagao Cheng* Discovery of potential neonicotinoid insecticides by an artificial intelligence generative model and structure-based virtual screening. J. Agric. Food Chem. 2024, 72, 5145–5152.(一區(qū)TOP)
5. Cong Zhou, Guanglong Li, Sihui Wang, Zhong Li, Xuhong Qian, and Jiagao Cheng* Novel insecticidal benzo[4,5]imidazo[1,2-b]pyrazole derivatives identified through ring-closure scaffold hopping on fipronil. Chem. Biodivers. 2024, e202402148.
6. Xiaoyang Li#, Cong Zhou#, Wulin Yang, Zhong Li, and Jiagao Cheng* Novel insecticidal pyridylhydrazono derivatives identified via scaffold hopping and conformation regulation strategies. Chem. Biodivers. 2024, e202401767.
7. Xiaoyang Li#, Cong Zhou#, Lujue He, Zhiping Xu, Zhong Li, and Jiagao Cheng* Identification of potential novel insect TRPV channel modulators by homology modeling, binding mode analysis, virtual screening studies and chemical optimization. New J. Chem., 2024, 48, 12688-12696.
8. Cong Zhou, Zhong Li, Xuhong Qian, Jiagao Cheng*, and Peter Maienfisch* Novel acaricidal silico-containing pyrazolyl acrylonitrile derivatives identified through rational carbon?silicon bioisosteric replacement strategy. J. Agric. Food Chem. 2023, 71, 18239–18249.一區(qū)TOP)
9. Cong Zhou, Xujuan Sun, Wen Fu, Zhong Li, Jiagao Cheng*, and Peter Maienfisch*Rational exploration of novel SDHI fungicide through amide-β-ketonitrile bioisosteric replacement strategy. J. Agric. Food Chem. 2023, 71, 5483–5495.(一區(qū)TOP)
10. Cong Zhou, Xin Wang, Xiaocao Quan, Jiagao Cheng*, Zhong Li, and Peter Maienfisch*.Silicon-containing complex II acaricides-design, synthesis, and pharmacological optimization. J. Agric. Food Chem. 2022, 70, 11063–11074.(一區(qū)TOP)
11. Cong Zhou, Jiagao Cheng*, Ryan Beadle, Fergus G Earley, Zhong Li, Peter Maienfisch*.Design, synthesis and acaricidal activities of Cyflumetofen analogues based on carbon-silicon isosteric replacement. Bioorgan. Med. Chem. 2020, 28, 115509.
12. Ting Li#, Cong Zhou#, Nan Zheng, Hongbin Yang, Guanglin Kuang, Xusheng Shao, Zhong Li, Jiagao Cheng*. Insights into the synergistic mechanism of target resistance: A case study of N. lugens RDL-GABA receptors and fipronil. Biophys. Chem.2020, 265, 106426.
申請(qǐng)專利
1. (中國發(fā)明專利授權(quán))程家高,Peter Maienfsch,周聰,李忠,邵旭升,徐曉勇,錢旭紅. 含硅酰基乙腈化合物及其制備方法與應(yīng)用. 專利號(hào) ZL 201910415131.9. 授權(quán)日:2021-02-09
2. (中國發(fā)明專利授權(quán))程家高,Peter Maienfsch,周聰,李忠,邵旭升,徐曉勇,錢旭紅. 硅丙烯腈類化合物及其制備方法與應(yīng)用. 專利號(hào) ZL 202011460379.6. 授權(quán)日:2024-10-25
3. (國際發(fā)明專利公開)程家高,Peter Maienfsch,周聰,李忠,邵旭升,徐曉勇,錢旭紅. 硅丙烯腈類化合物及其制備方法與應(yīng)用. 公開號(hào) WO 2022121908 A1. 公開日2022-06-16
4. (中國發(fā)明專利公開)程家高,周聰,Peter Maienfsch,李忠,邵旭升,徐曉勇,錢旭紅. 酮腈類化合物及其制備方法與應(yīng)用. 公開號(hào) CN 117658935 A. 公開日2024-03-08.
5. (中國發(fā)明專利公開)程家高,程亮亮,周聰,李忠,邵旭升,徐曉勇,錢旭紅. 一種長(zhǎng)鏈酮腈類化合物及其制備方法與應(yīng)用. 公開號(hào) CN 119462506 A 公布日2025-02-18
6. (中國發(fā)明專利申請(qǐng))程家高,周聰,李曉陽,王叢,吳彪,孫緒娟,李忠,邵旭升,徐曉勇,錢旭紅. 一種硫酯類化合物及其制備方法與應(yīng)用. 申請(qǐng)?zhí)枺?/span>202510087352.3