個(gè)人簡(jiǎn)介：

2014年博士畢業(yè)于中國(guó)科學(xué)院大學(xué)；在中國(guó)科學(xué)院生命科學(xué)研究院營(yíng)養(yǎng)科學(xué)研究所從事博士后工作；2017年人才引進(jìn)到天津醫(yī)科大學(xué)，基礎(chǔ)醫(yī)學(xué)院藥理系副教授、碩士生導(dǎo)師；2021年12月至今，華東理工大學(xué)藥學(xué)院藥物科學(xué)系，特聘研究員/副教授，博士生導(dǎo)師。

        作為項(xiàng)目負(fù)責(zé)人主持國(guó)家自然科學(xué)基金面上項(xiàng)目2項(xiàng)、國(guó)家自然科學(xué)基金青年項(xiàng)目、京津冀基礎(chǔ)研究合作專項(xiàng)、天津市自然科學(xué)基金等，作為項(xiàng)目骨干參與國(guó)家重點(diǎn)研發(fā)計(jì)劃等。曾獲2021年度華夏醫(yī)學(xué)科技獎(jiǎng)二等獎(jiǎng)；中國(guó)中醫(yī)科學(xué)院科學(xué)技術(shù)二等獎(jiǎng)；2018年天津市青年人才托舉工程；2018年天津市創(chuàng)新人才推進(jìn)計(jì)劃青年科技優(yōu)秀人才；2017年天津市131創(chuàng)新型人才培養(yǎng)工程等。主要學(xué)術(shù)兼職包括世界中醫(yī)藥學(xué)會(huì)聯(lián)合會(huì)氣血專業(yè)委員會(huì)理事、中國(guó)心胸血管麻醉學(xué)會(huì)精準(zhǔn)醫(yī)療分會(huì)委員、中國(guó)藥理學(xué)會(huì)心血管藥理專業(yè)委員會(huì)青年學(xué)者、中國(guó)醫(yī)藥教育協(xié)會(huì)中醫(yī)藥慢病防治與教育工作委員會(huì)委員、中國(guó)青年科技工作者協(xié)會(huì)第六屆生物醫(yī)藥專委會(huì)會(huì)員、上海市衰老與退行性疾病學(xué)會(huì)青年委員、天津院士專家工作發(fā)展促進(jìn)會(huì)理事、《血管生物學(xué)》編委、Frontiers in Pharmacology期刊副主編等。

研究方向：

       心血管疾病及相關(guān)代謝綜合征的機(jī)制研究和新靶標(biāo)的發(fā)現(xiàn)。

近五年代表性論文：

1. Xiang Peng, Bin Sun, Chaohui Tang, Chengyu Shi, Xianwei Xie, Xueyu Wang, Dingsheng Jiang, Shuo Li, Ying Jia, Yani Wang, Huifang Tang, Shan Zhong, Minghui Piao, Xiuru Cui, Shenghao Zhang, Fan Wang, Yan Wang, Ruisi Na, Renping Huang, Yanan Jiang, Weihua Zhang, Juan Xu, Kaiyang Lin, Junli Guo, Zhenwei Pan, Kun Wang, Qiang Zhao, Huibin Liu, Yong Ji, Bo Yu, Jian Zhang*, Shuijie Li*, Jinwei Tian*. LDHB is essential for HMOX1-dependent ferroptosis through regulating mitochondrial function of foamy macrophages in advanced atherosclerosis. Developmental Cell. Accepted.

2. Fangdi Zou, Yong Li, Shijie Zhang, Jian Zhang*. DP1 Activation Protects Against Vascular Remodeling and VSMC Transition to Myofibroblasts in Angiotensin II-induced Hypertension in Mice. Hypertension. 2021 Jan 31^th Accepted.（心血管國(guó)際頂級(jí)期刊）

3. Daile Jia, Peiyuan Bai, Naifu Wan, Jiao Liu, Qian Zhu, Yuhu He, Guilin Chen, Jing Wang, Han Chen, Chen Wang, Ankang Lyu, Michael Lazarus, Yunchao Su, Yoshihiro Urade, Ying Yu*, Jian Zhang*, Yujun Shen*. Niacin Attenuates Pulmonary Hypertension Through H-PGDS in Macrophages.Circulation Research. 2020;127:1323–1336. （心血管國(guó)際頂級(jí)期刊）

4.Xiangjun Yin, Min Li, Yongzhi Wang, Guifang Zhao, Tao Yang, Yuqing Zhang, Jianbo Guo, Tiantian Meng, Ruolin Du, Honglin Li*, Zhe Wang*, Jian Zhang*, Qingyong He*. Herbal medicine formula Huazhuo Tiaozhi granule ameliorates dyslipidaemia via regulating histone lactylation and miR-155-5p biogenesis. Clinical Epigenetics. 2023;15(1):175. 

5. Shumin Guo, Rui Zhang, Qian Liu,Qiangyou Wan, Yuanyang Wang, Yu Yu, Guizhu Liu, Yujun Shen, Lijian Hui, Ying Yu, Jian Zhang*. 2,3,7,8-Tetrachlorodibenzo-p-dioxin promotes injury-induced vascular neointima formation in mice through c-Jun activation. FASEB J. 2019;33(9):10207-10217. 

6. Guizhu Liu, Qian Liu, Yujun Shen, Deping Kong, Yanjun Gong, Bo Tao, Guilin Chen, Shumin Guo, Juanjuan Li, Shengkai Zuo, Yu Yu, Huiyong Yin, Li Zhang, Bin Zhou, Colin D Funk, Jian Zhang*, Ying Yu*. Early treatment with Resolvin E1 facilitates myocardial recovery from ischaemia in mice. Brit J Pharmacol. 2018; 175:1205–1216. （藥理學(xué)頂級(jí)期刊）

7. Guizhu Liu, Yanjun Gong, Rui Zhang, Lingjuan Piao, Xinzhi Li, Qian Liu, Shuai Yan, Yujun Shen, Shumin Guo, Mingjiang Zhu, Huiyong Yin, Colin D. Funk, Jian Zhang*, Ying Yu*. Resolvin E1 attenuates injury-induced vascular neointimal formation by inhibition of inflammatory responses and vascular smooth muscle cell migration.FASEB J. 2018; 32(10):5413-5425.

8. Mulin Jun Li^#, Jian Zhang^#, Jiexing Wu, Peng Jiang, Wei Li, Yun Zhu, Daniel Fernandez, Russell J. H. Ryan, Yiwen Chen , Junwen Wang , Jun S. Liu, X. Shirley Liu. Exploring genetic associations with ceRNA regulation in the human genome. Nucleic Acids Research. 2017 Jun 2;45(10):5653-5665.（生物學(xué)TOP期刊）

9. Qian Jiao, Fangdi Zou, Shiliang Li, Jiawen Wang, Yunping Xiao, Zhihua Guan, Liang Dong,Jinwei Tian, Shengqing Li, Rui Wang*, Jian Zhang*, Honglin Li*. Dexlansoprazole prevents pulmonary artery hypertension by inhibiting pulmonary artery smooth muscle cell to fibroblast transition. Am J Transl Res 2022;14(8):5466-5479.IF,3.9

10. Jian Zhang, Fangfang Zou, Juan Tang, Qianqian Zhang, Yanjun Gong, Qingsong Wang, YujunShen, Lixia Xiong, Richard M. Breyer, Michael Lazarus, Colin D. Funk, Ying Yu. Cyclooxygenase-2–derived prostaglandin E2 promotes injury-induced vascular neointimal hyperplasia through the E-prostanoid 3 receptor. Circulation Research. 2013;113(2):104-114. （心血管領(lǐng)域國(guó)際頂級(jí)期刊）

11. Jian Zhang, Yanjun Gong, Ying Yu. PGF_2alpha receptor: a promising therapeutic target for cardiovascular disease.Frontiers in Pharmacology. 2010; 1(116):1-7. 

12. Yong Li, Jian Zhang*. The role of arachidonic acid and its derivatives in the development of pulmonary arterial hypertension. Chinese Journal of Nature. 2022, 44(5): 357-368.

13. 倪文君，王雪羽，鐘珊，趙鵬，張健*，田進(jìn)偉*，腸道菌群和心血管疾病的免疫調(diào)節(jié).中國(guó)動(dòng)脈粥樣硬化.2023,31(7):625-631.

14. 血管生物學(xué)(第2版)，第三十章前列腺素與血管炎癥，余鷹，張健，北京大學(xué)醫(yī)學(xué)出版社，2014.

15. 花生四烯酸衍生物在腹主動(dòng)脈瘤發(fā)生發(fā)展中的作用，焦志昂，昌悅悅，孟碩，馬思靜，王哲，張健*，中國(guó)動(dòng)脈硬化雜志. 2024,32(05):75-81.