張健 特聘研究員/副教授 博士生導師
E-mail: zhangjian7@ecust.edu.cn
通訊地址：上海市徐匯區(qū)梅隴路130號實驗18樓723室；郵編：200237
個人簡介：
本科（2009年7月）畢業(yè)于河北大學生物科學專業(yè)；2014年畢業(yè)于中國科學院大學生物化學與分子生物學專業(yè)，獲得理學博士學位。2014年至2016年，在中國科學院生命科學研究院營養(yǎng)科學研究所從事博士后工作；2016年底，人才引進到天津醫(yī)科大學，基礎(chǔ)醫(yī)學院藥理系副教授、碩士生導師；2021年12月至今，華東理工大學藥學院藥物科學系，特聘研究員/副教授，博士生導師。
作為項目負責人主持國家自然科學基金面上項目、國家自然科學基金青年項目、京津冀基礎(chǔ)研究合作專項、天津市自然科學基金等，作為項目骨干參與國家重點研發(fā)計劃等。曾獲2021年度華夏醫(yī)學科技獎二等獎（第三完成人）；2018年天津市青年人才托舉工程；2018年天津市創(chuàng)新人才推進計劃青年科技優(yōu)秀人才；2017年天津市131創(chuàng)新型人才培養(yǎng)工程。主要學術(shù)兼職包括天津院士專家工作發(fā)展促進會理事；中國青年科技工作者協(xié)會第六屆生物醫(yī)藥專委會會員；《血管生物學》編委，Frontiers in Pharmacology期刊副主編等。
研究方向：
心血管疾病及相關(guān)代謝綜合征的疾病機制研究和新靶標的發(fā)現(xiàn)。
近五年代表性論文：
1. Fangdi Zou, Yong Li, Shijie Zhang, Jian Zhang*. DP1 Activation Protects Against Vascular Remodeling and VSMC Transition to Myofibroblasts in Angiotensin II-induced Hypertension in Mice. Hypertension. 2021 Jan 31th Accepted.（心血管國際頂級期刊）
2.Daile Jia, Peiyuan Bai, Naifu Wan, Jiao Liu, Qian Zhu, Yuhu He, Guilin Chen, Jing Wang, Han Chen, Chen Wang, Ankang Lyu, Michael Lazarus, Yunchao Su, Yoshihiro Urade, Ying Yu*, Jian Zhang*, Yujun Shen*. Niacin Attenuates Pulmonary Hypertension Through H-PGDS in Macrophages.Circulation Research. 2020;127:1323–1336. （心血管國際頂級期刊）
3. Shumin Guo, Rui Zhang, Qian Liu,Qiangyou Wan, Yuanyang Wang, Yu Yu, Guizhu Liu, Yujun Shen, Lijian Hui, Ying Yu, Jian Zhang*. 2,3,7,8-Tetrachlorodibenzo-p-dioxin promotes injury-induced vascular neointima formation in mice through c-Jun activation. FASEB J. 2019;33(9):10207-10217.
4.Guizhu Liu, Qian Liu, Yujun Shen, Deping Kong, Yanjun Gong, Bo Tao, Guilin Chen, Shumin Guo, Juanjuan Li, Shengkai Zuo, Yu Yu, Huiyong Yin, Li Zhang, Bin Zhou, Colin D Funk, Jian Zhang*, Ying Yu*. Early treatment with Resolvin E1 facilitates myocardial recovery from ischaemia in mice. Brit J Pharmacol. 2018; 175:1205–1216. （藥理學頂級期刊）
5. Guizhu Liu, Yanjun Gong, Rui Zhang, Lingjuan Piao, Xinzhi Li, Qian Liu, Shuai Yan, Yujun Shen, Shumin Guo, Mingjiang Zhu, Huiyong Yin, Colin D. Funk, Jian Zhang*, Ying Yu*. Resolvin E1 attenuates injury-induced vascular neointimal formation by inhibition of inflammatory responses and vascular smooth muscle cell migration.FASEB J. 2018; 32(10):5413-5425.
6. Mulin Jun Li#, Jian Zhang#, Jiexing Wu, Peng Jiang, Wei Li, Yun Zhu, Daniel Fernandez, Russell J. H. Ryan, Yiwen Chen , Junwen Wang , Jun S. Liu, X. Shirley Liu. Exploring genetic associations with ceRNA regulation in the human genome. Nucleic Acids Research. 2017 Jun 2;45(10):5653-5665.（生物學TOP期刊）
7. Jian Zhang, Fangfang Zou, Juan Tang, Qianqian Zhang, Yanjun Gong, Qingsong Wang, YujunShen, Lixia Xiong, Richard M. Breyer, Michael Lazarus, Colin D. Funk, Ying Yu. Cyclooxygenase-2–derived prostaglandin E2 promotes injury-induced vascular neointimal hyperplasia through the E-prostanoid 3 receptor. Circulation Research. 2013;113(2):104-114. （心血管領(lǐng)域國際頂級期刊）
7. Jian Zhang, Yanjun Gong, Ying Yu. PGF2alpha receptor: a promising therapeutic target for cardiovascular disease.Frontiers in Pharmacology. 2010; 1(116):1-7.
8. Yu Hu He, Xiao Qun Wang,Jian Zhang,Zhu Hui Liu, Wen Qi Pan, Ying Shen, Zheng Bin Zhu, Ling Jie Wang, Xiao Xiang Yan, Ke Yang, Rui Yan Zhang, Wei Feng Shen, Feng Hua Ding, Lin Lu. Association of serum HMGB2 levels with in-stent restenosis: HMGB2 promotes neointima hyperplasia in mice with femoral artery injury and proliferation and migration of VSMCs. Arteriosclerosis Thrombosis and Vascular Biology. 2017 Apr;37(4):717-729. （血液學TOP期刊）
9. Guilin Chen, Shengkai Zuo, Juan Tang, Caojian Zuo, Daile Jia, Qian Liu, Guizhu Liu, Qian Zhu, Yuanyang Wang, Jian Zhang, Yujun Shen, Dongrui Chen, Ping Yuan, Zhiqiang Qin, Chengchao Ruan, Jue Ye, Xiao-Jian Wang, Yuping Zhou, Pingjin Gao, Peng Zhang, Jinming Liu, Zhi-Cheng Jing, Ankang Lu, Ying Yu*. Inhibition of CRTH2-mediated Th2 activation attenuates pulmonary hypertension in mice. J Exp Med. 2018; 215(8):2175-2195.
10. Shengkai Zuo, Deping Kong, Chenyao Wang, Jiao Liu, Yuanyang Wang, Qiangyou Wan, Shuai Yan, Jian Zhang, Juan Tang, Qianqian Zhang, Luheng Lyu, Xin Li, Zhixin Shan, Li Qian, Yujun Shen*, Ying Yu*. CRTH2 promotes endoplasmic reticulum stress-induced cardiomyocyteapoptosis through m-calpain. EMBO Mol Med.2018; 10(3). pii: e8237.
11. Juan Tang, Yujun Shen, Guilin Chen, Qiangyou Wan, Kai Wang, Jian Zhang, Jing Qin, Guizhu Liu, Shengkai Zuo, Bo Tao, Yu Yu, Junwen Wang, Michael Lazarus, Ying Yu*. Activation of E-prostanoid 3 receptor in macrophages facilitates cardiac healing after myocardial infarction. Nat Commun. 2017; 8:14656.
12. Di Chen, Juan Tang, Qiangyou Wan, Jian Zhang, Kai Wang, Yujun Shen*, Ying Yu*. E-prostanoid 3 receptor mediates sprouting angiogenesis through suppression of the protein kinase A/β-catenin/Notch pathway. Arterioscler Thromb Vasc Biol. 2017; 37(5):856-866. （血液學TOP期刊）
