李寫(xiě) 特聘副研究員 碩士生導(dǎo)師
E-mail: xieli@ecust.edu.cn
通訊地址：上海市徐匯區(qū)梅隴路130號(hào)，第六教學(xué)樓輔樓316室；郵編：200237
【個(gè)人簡(jiǎn)介】
李寫(xiě)，博士，華東理工大學(xué)特聘副研究員，上海市細(xì)胞代謝光遺傳學(xué)技術(shù)前沿科學(xué)研究基地和光遺傳學(xué)與合成生物學(xué)交叉學(xué)科研究中心成員。2018年9月畢業(yè)于華東理工大學(xué)藥學(xué)院，獲理學(xué)博士學(xué)位。隨后加入光遺傳學(xué)與合成生物學(xué)交叉學(xué)科研究中心團(tuán)隊(duì)。迄今以第一作者（含共一）發(fā)表于Cell Metabolism、PNAS、Nucleic Acids Research、Trends in Cell Biology和Cell Reports，以共同作者在Nature Communications和The Journal of Clinical Investigation發(fā)表論文4篇，授權(quán)4項(xiàng)中國(guó)發(fā)明專(zhuān)利，申請(qǐng)11項(xiàng)國(guó)際PCT發(fā)明專(zhuān)利和17項(xiàng)中國(guó)發(fā)明專(zhuān)利。主持國(guó)自然青年科學(xué)基金項(xiàng)目、上海市自然科學(xué)基金面上項(xiàng)目等項(xiàng)目，獲得第十七屆細(xì)胞生物學(xué)青年論壇技術(shù)創(chuàng)新獎(jiǎng)。
【研究方向】
遺傳編碼熒光探針的開(kāi)發(fā)與應(yīng)用
光遺傳學(xué)技術(shù)的開(kāi)發(fā)與應(yīng)用
【發(fā)表論文】
1. Xie Li#, Yinan Zhang#, Lingyan Xu#, Aoxue Wang#, Yejun Zou#, Ting Li#, Li Huang#, Weicai Chen#, Shuning Liu, Kun Jiang, Xiuze Zhang, Dongmei Wang, Lijuan Zhang, Zhuo Zhang, Zeyi Zhang, Xianjun Chen, Wei Jia, Aihua Zhao, Xinfeng Yan, Haimeng Zhou, Linyong Zhu, Xinran Ma, Zhenyu Ju, Weiping Jia, Congrong Wang*, Joseph Loscalzo, Yi Yang* and Yuzheng Zhao*. Ultrasensitive sensors reveal the spatiotemporal landscape of lactate metabolism in physiology and disease. Cell Metabolism, 2023, 35(1), 200-211.
2. Xie Li, Changcheng Zhang, Xiaopei Xu, Jun Miao, Jing Yao, Renmei Liu, Yuzheng Zhao, Xianjun Chen* and Yi Yang*. A single-component light sensor system allows highly tunable and direct activation of gene expression in bacterial cells. Nucleic Acids Research, 2020, 48(6), e33.
3. Dan huang#, Changcheng Zhang#, Ming Xiao#, Xie Li#, Weicai Chen#, Yu Jiang, Yamin Yuan, Yaping Zhang, Yejun Zou, Lei Deng, Yang Wang, Yuying Sun, Wenping Dong, Zhuo Zhang, Li Xie, Zhuo Yu, Chiqi Chen, Ligen Liu, Jing Wang, Yi Yang*, Jie Yang*, Yuzheng Zhao* and Junke Zheng*. Redox metabolism maintains the leukemogenic capacity and drug resistance of AML cells. PNAS, 2023, 120 (13), e2210796120.
4. Zhuo Zhang#, Chiqi Chen#, Xie Li#, Junke Zheng*, Yuzheng Zhao*. Regulation of leukemogenesis via redox metabolism. Trends in Cell Biology, 2023, online, doi.org/10.1016/j.tcb.2023.10.001.
5. Xiaoye Liu#, Feifei Zhang#, Yaping Zhang#, Xie Li#, Chiqi Chen#, Meiyi Zhou, Zhuo Yu, Yunxia Liu, Yuzheng Zhao, Xiaoxin Hao, Yabin Tang, Liang Zhu, Ligen Liu, Li Xie, Hao Gu, Hongfang Shao, Fangzhen Xia, Chunrong Yin, Minfang Tao, Jingjing Xie, Cheng Cheng Zhang, Yi Yang, Haipeng Sun*, Guo-Qiang Chen*and Junke Zheng*. PPM1K regulates hematopoiesis and leukemogenesis through CDC20-mediated ubiquitination of MEIS1 and p21. Cell Reports, 2018, 23(5), 1461-1475.
6. Mengshu Jia#, XiaoYue#, Weixia Sun#, Qianjun Zhou#, ChengChang#, Weihua Gong, Jian Feng, Xie Li, Ruonan Zhan, Kemin Mo, Lijuan Zhang, Yajie Qian, Yuying Sun, Aoxue Wang, YejunZou, Weicai Chen, Yan Li, Li Huang, Yi Yang*, Yuzheng Zhao*, Xiawei Cheng*. ULK1-mediated metabolic reprogramming regulates Vps34 lipid kinase activity by its lactylation. Science Advances, 2023, 9, eadg499.
7. Ting Li#, Xianjun Chen#, Yajie Qian, Jiawei Shao, Xie Li, Shuning Liu, Linyong Zhu, Yuzheng Zhao, Haifeng Ye* and Yi Yang*. A synthetic BRET-based optogenetic device for pulsatile transgene expression enabling glucose homeostasis in mice. Nature Communications, 2021, 12, 615.
8. Xiaoxiao He#, Jiangbo Wan#, Xiaona Yang, Xiuze Zhang, Dan Huang, Xie Li, Yejun Zou, Chiqi Chen, Zhuo Yu, Li Xie, Yaping Zhang, Ligen Liu, Shangang Li, Yuzheng Zhao, Hongfang Shao*, Ye Yu* and Junke Zheng*. Bone marrow niche ATP levels determine leukemia-initiating cell activity via P2X7 in leukemic models. The Journal of Clinical Investigation, 2021, 131(4): e140242.
9. Kai Yang, Ming Wang, Yuzheng Zhao, Xuxu Sun, Yi Yang, Xie Li, Aiwu Zhou, Huilin Chu, Hu Zhou, Jianrong Xu, Mian Wu, Jie Yang* and Jing Yi*. A redox mechanism underlying nucleolar stress sensing by nucleophosmin. Nature Communications, 2016, 7, 13599.
