李婷     博士/特聘副研究員/碩導(dǎo)

       電話/傳真：021-64251287

              E-mail:  tingli@ecust.edu.cn

      通訊地址：上海市徐匯區(qū)梅隴路130號實驗十八樓733；郵編：200237

個人簡介

2018年9月畢業(yè)于華東理工大學(xué)藥學(xué)院，獲生物化學(xué)與分子生物學(xué)專業(yè)的博士學(xué)位，隨后進入華東理工大學(xué)藥學(xué)專業(yè)從事博士后研究工作。2022年7月出站留校工作，被聘為特聘副研究員，在趙玉政教授團隊從事教學(xué)科研工作。

聚焦細胞代謝監(jiān)控技術(shù)開發(fā)與生物醫(yī)藥研究，通過細胞藥物治療、高通量代謝藥物篩選、在體可視化追蹤、藥物靶點研究及臨床疾病危險標志物發(fā)現(xiàn)等方式揭示生命過程的化學(xué)本質(zhì)，解析疾病發(fā)生發(fā)展機制，促進生物醫(yī)藥的發(fā)展。主要研究成果發(fā)表在Cell Metabolism、Nature Communications、Nature Protocols、Nucleic Acids Research等國內(nèi)外知名學(xué)術(shù)期刊。入選2019年上海市青年科技英才揚帆計劃，同年獲得國家自然科學(xué)基金青年科學(xué)基金項目和中國博士后科學(xué)基金面上項目。

研究方向

1. 基于光遺傳學(xué)的細胞控制技術(shù)的開發(fā)與應(yīng)用

2. 細胞代謝監(jiān)測成像新技術(shù)的開發(fā)與應(yīng)用

    

代表性論文

1. Rui Li^#, Yan Li^#, Kun Jiang^#, Lijuan Zhang^#, Ting Li^#, Aihua Zhao#, Zhuo Zhang, Yale Xia, Kun Ge, Yaqiong Chen, Chengnuo Wang, Weitao Tang, Shuning Liu, Xiaoxi Lin, Yuqin Song, Jie Mei, Chun Xiao, Aoxue Wang, Yejun Zou, Xie Li, Xianjun Chen, Zhenyu Ju, Wei Jia, Joseph Loscalzo8, Yu Sun, Wei Fang*, Yi Yang*, Yuzheng Zhao*. Lighting up arginine metabolism reveals its functional diversity in physiology and pathology, Cell Metabolism, 2024, in press.

2. Aoxue Wang^#, Yejun Zou^#, Shuning Liu^#, Xiuze Zhang^#, Ting Li*, Lijuan Zhang, Ruwen Wang, Yale Xia, Xie Li, Zhuo Zhang, Tiemin Liu, Zhenyu Ju, Ru Wang*, Joseph Loscalzo, Yi Yang*, Yuzheng Zhao*. Comprehensive multiscale analysis of lactate metabolic dynamics in vitro and in vivo using highly responsive biosensors, Nature Protocols, 2024, 19(5), 1311–1347.

3. Fei Pan^#, Cheng-Nuo Wang^#, Zhuo-Hang Yu^#, Zeng-Rui Wu, Ze Wang, Shang Lou, Wei-Hua Li, Gui-Xia Liu, Ting Li*, Yu-Zheng Zhao, Yun Tang*. NADPHnet: a novel strategy to predict compounds for regulation of NADPH metabolism via network-based methods. Acta Pharmacologica Sinica, 2024, 45(10), 2199-2211.  

4. Xie Li^#, Yinan Zhang^#, Lingyan Xu^#, Aoxue Wang^#, Yejun Zou^#, Ting Li^#, Li Huang^#, Weicai Chen^#, Shuning Liu, Kun Jiang, Xiuze Zhang, Dongmei Wang, Lijuan Zhang, Zhuo Zhang, Zeyi Zhang, Xianjun Chen, Wei Jia, Aihua Zhao, Xinfeng Yan, Linyong Zhu, Xinran Ma, Zhenyu Ju, Weiping Jia, Congrong Wang*, Joseph Loscalzo, Yi Yang*, Yuzheng Zhao*. Ultrasensitive sensors reveal the spatiotemporal landscape of lactate metabolism in physiology and disease. Cell Metabolism, 2023, 35(1), 200-211.

5. Yajie Qian^#, Ting Li^#, Siyu Zhou, Xianjun Chen* and Yi Yang*. A single-component optogenetic Gal4-UAS system allows stringent control of gene expression in zebrafish and Drosophila. ACS Synthetic Biology, 2023, 12(3), 664-671.

6. Ting Li^#, Yejun Zou^#, Shuning Liu, Yi Yang, Zhuo Zhang*, Yuzheng Zhao*. Monitoring NAD(H) and NADP(H) dynamics during organismal development with genetically encoded fluorescent biosensors.Cell Regeneration, 2022, 11(1): 5.

7. Ting Li^#, Xianjun Chen^#, Yajie Qian, Jiawei Shao, Xie Li, Shuning Liu, Linyong Zhu, Yuzheng Zhao, Haifeng Ye* and Yi Yang*. A synthetic BRET-based optogenetic device for pulsatile transgene expression enabling glucose homeostasis in mice. Nature Communications, 2021, 12(1): 615.

8. Xianjun Chen^#, Ting Li^#, Xue Wang, Zengmin Du, Renmei Liu, and Yi Yang*. Synthetic dual-input mammalian genetic circuits enable tunable and stringent transcription control by chemical and light, Nucleic Acids Research, 2016, 44(6): 2677-2690.