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| 發(fā)布時(shí)間：2018-10-22 訪問次數(shù):11670 作者:洪鳴凰 |
副研究員 聯(lián)系信息 教育經(jīng)歷 工作經(jīng)歷 2014.01-今 華東理工大學(xué)藥學(xué)院 副研究員 2010.08-2013.12 上海醫(yī)藥工業(yè)研究院 副研究員 2009.07-2010.07 上海開拓者醫(yī)藥發(fā)展有限公司 研究員
研究方向 第一部分 工業(yè)藥學(xué)——處方前研究和制劑學(xué)研究 研究方向：1. 藥物晶型研究，包括晶型篩選、鹽型篩選、共晶、離子液體、固態(tài)表征及質(zhì)量標(biāo)準(zhǔn)制定 2. 固體藥物制劑開發(fā) 3. 制劑研發(fā)中的晶型問題，包括制劑中藥用晶型的判定、晶型轉(zhuǎn)化及質(zhì)量標(biāo)準(zhǔn) 第二部分 基礎(chǔ)研究——腫瘤靶向納米載藥系統(tǒng) 研究方向：以納米載藥系統(tǒng)（包括脂質(zhì)體、納米粒、非粒子表面活性劑泡囊和共軛物）為載體，將抗腫瘤藥物遞送至腫瘤部位而實(shí)現(xiàn)靶向治療。 發(fā)表文章 Hao Wu, Zhaizhu Deng, Bijian Zhou, Minghui Qi, Minghuang Hong?, Guobin Ren?. Improved transdermal permeability of ibuprofen by ionic liquid technology: Correlation between counterion structure and the physicochemical and biological properties, J. Mol. Liq., 2019, 283:399-409. Minghuang Hong, Sai Guo, Kai Wang, Lei Ma?, Guobin Ren?, Influence factor investigation on the solution-mediated polymorphic transformation of Baricitinib phosphate, Z. Anorg. Allg. Chem., 2018, 644:849-855. Minghuang Hong#, Jingyan Chen#, Hui Zhou, Hao Xu, Guobin Ren?, Investigation of a solution-mediated phase transformation of pranlukast DMF solvate to hemihydrate, Cryst. Res. Technol., 2017, 52(6): 1700045. Minghuang Hong#, Shiwang Wu#, Minghui Qi, Guobin Ren?, Solubility correlation and thermodynamic analysis of two forms of metaxalone in different pure solvents, Fluid Phase Equilib., 2016, 409: 1-6. Ming-Hui Qi#, Ming-Huang Hong#, Yan Liu, En-Fu Wang, Fu-Zheng Ren, Guo-Bin Ren?, Estimating thermodynamic stability relationship of polymorphs of sofosbuvir, Cryst. Growth Des., 2015, 15(10): 5062-5067. Minghuang Hong#, Lehui Xu#, Guobin Ren?, Jinyao Chen, Minghui Qi, Solubility of lansoprazole in different solvents, Fluid Phase Equilib., 2012, 331: 18-25. Minghuang Hong, Saijie Zhu, Yanyan Jiang, Guotao Tang, Chang Sun, Chao Fang, Bin Shi, and Yuanying Pei?, Novel anti-tumor strategy: PEG-hydroxycamptothecin conjugate loaded transferrin-PEG-nanoparticles, J Control Release, 2010, 141: 22-29. Minghuang Hong, Saijie Zhu, Yanyan Jiang, Guotao Tang, and Yuanying Pei?, Efficient tumor targeting of hydroxycamptothecin loaded PEGylated niosomes modified with transferrin, J Control Release,2009,133, 96-102. Guo-Bin Ren?, Ming-Huang Hong, Jia-Liang Zhong, Dong-Xu Yi, Le-Hui Xu, 2-{[3-Methyl-4-(2,2,2-trifluoroethoxy)-pyridin-2-yl]methylsulfanyl}-1H-benzimidazole monohydrate, Acta Cryst., 2011, E67: o270. Saijie Zhu, Minghuang Hong, Guotao Tang, Lili Qian, Jiayuan Lin, Yanyan Jiang, and Yuanying Pei?, Partly PEGylated polyamidoamine dendrimer for tumor-selective targeting of doxorubicin: the effects of PEGylation degree and drug conjugation style, Biomaterials, 2010, 31: 1360-1371. Saijie Zhu, Minghuang Hong, Lihong Zhang, Guotao Tang, Yanyan Jiang, and Yuanying Pei?, PEGylated PAMAM dendrimer-doxorubicin conjugates: in vitro evaluation, and in vivo tumor accumulation, Pharm. Res-Doror., 2010, 27: 161-173. Saijie Zhu, Minghuang Hong, Chen Liu, and Yuanying Pei?, Application of Box-Behnken design in understanding the quality of genistein self-nanoemulsified drug delivery systems and optimizing its formulation. Pharm. Dev. Technol., 2009, 14, 642-649. Jinju Ma, Ming-Hui Qi, Ming-Huang Hong, Jie Lu, Guo-Bin Ren?, 2-{[3-Methyl-4-(2,2,2-trifluoroethoxy)-pyridin-2-yl]methylsulfanyl}-1H-benzimidazole propan-2-ol monosolvate: a second monoclinic polymorph, Acta Cryst., 2012, E68: o2017 Yu-Feng Chen, Jin-Yao Chen, Ming-Huang Hong, Jie Lu, Guo-Bin Ren?, 2-{[3-Methyl-4-(2,2,2-trifluoroethoxy)-pyridin-2-yl]methylsulfanyl}-1H-benzimidazole monohydrate: a monoclinic polymorph, Acta Cryst., 2012, E68: o2015-o2016 Wenhua Chen, Ne Guo, Minghui Qi, Haiying Dai, Minghuang Hong, Longfei Guan, Xiajuan Huan, Shanshan Song, Jinxue He, Yingqing Wang, Yong Xi, Xinying Yang, Yanyan Shen, Yi Su, Yiming Sun, Yinglei Gao, Yi Chen, Jian Ding, Yun Tang, Guobin Ren, Zehong Miao, Jian Li?,Discovery, mechanism and metabolism studies of 2,3-difluorophenyl-linker-containing PARP1 inhibitors with enhanced in vivo efficacy for cancer therapy, Eur. J. Med. Chem., 2017, 138: 514-531 Saijie Zhu, Lili Qian, Minghuang Hong, Lihong Zhang, Yuanying Pei, and Yanyan Jiang?, RGD-Modified PEG-PAMAM-DOX Conjugate: In vitro and in vivo targeting to both tumor neovascular endothelial cells and tumor cells. Adv. Mater., 2011, 23: 84-89. Saijie Zhu, Rongqin Huang, Minghuang Hong, Yanyan Jiang, Zhuohan Hu, Chen Liu, Yuanying Pei?, Effects of polyoxyethylene (40) stearate on the activity of P-glycoprotein and cytochrome P450. Eur. J Pharm. Sci., 2009, 37: 573-580.
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