張永強 教授 博士生導(dǎo)師/碩士生導(dǎo)師

聯(lián)系方式：

通訊地址：華東理工大學(xué)實驗十四樓西側(cè)402，郵編200237

電話：021-64253299

電郵：yongqiangzhang@ecust.edu.cn

個人簡介：

2013年畢業(yè)于第二軍醫(yī)大學(xué)(現(xiàn)海軍軍醫(yī)大學(xué))藥學(xué)院藥物化學(xué)專業(yè)，獲醫(yī)學(xué)博士學(xué)位，導(dǎo)師張萬年教授和盛春泉教授。后赴美國猶他大學(xué)化學(xué)系生物有機專業(yè)從事博士后研究，合作導(dǎo)師季海濤助理教授。2016年1月回國受聘于華東理工大學(xué)藥學(xué)院，從事藥物化學(xué)教學(xué)和科研工作。先后主持國家自然科學(xué)基金青年基金1項、面上項目3項、上海市自然科學(xué)基金面上項目1項、教育部高校基本科研業(yè)務(wù)費1項；參編英文論著一部(Targeting Protein-Protein Interactions by Small Molecules)、中文論著一部(藥物合成—路線設(shè)計策略和案例解析)；已在國際核心刊物如J. Am. Chem. Soc., Angew. Chem. Int. Ed., Chem. Sci., Green Chem., Org. Lett., Chem. Commun., J. Med. Chem. 等上發(fā)表20余篇SCI論文。

研究方向：

1、基于天然產(chǎn)物結(jié)構(gòu)改造策略的新藥創(chuàng)制

2、新型自由基反應(yīng)開發(fā)及其在拓展化學(xué)空間中的應(yīng)用

研究項目：                                                          

抗腫瘤天然產(chǎn)物那可丁(Noscapine)的全合成與結(jié)構(gòu)改造, 國家自然科學(xué)基金青年基金, 20萬，主持，已結(jié)題      

基于自由基型環(huán)醚碳?xì)?/span>(Cα)芳基化策略的芳基碳糖苷合成研究，國家自然科學(xué)基金面上項目，65萬，主持，已結(jié)題

可見光/硼(硅)原子轉(zhuǎn)移協(xié)同催化的碳-硅鍵構(gòu)建反應(yīng)研究，國家自然科學(xué)基金面上項目，60萬，主持，在研

多氟芳硒基硅烷類光敏試劑的設(shè)計合成及其在低能可見光促進(jìn)碳硒鍵構(gòu)建中的應(yīng)用，國家自然科學(xué)基金面上項目，50萬，主持，在研

可見光/有機硒協(xié)同催化硅氯鍵活化技術(shù)開發(fā)驅(qū)動的碳硅鍵構(gòu)建反應(yīng)研究，上海市自然科學(xué)基金面上項目，20萬，主持，在研

基于自由基的碳?xì)浠罨夹g(shù)與碳核苷合成, 教育部基本科研業(yè)務(wù)費, 16萬，主持，已結(jié)題

代表性論文：

回國后研究工作(2016年-至今)：

1.Guangwei Cui^#, Yuhang Fan^#, Yue Yang, Yiwen Ma, Haiyang Deng, Pan Wang, Yuxin Zhu, Jian Li, Jinlian Wei,*and Yongqiang Zhang* (通訊作者). Discovery of N?Trifluoromethylated Noscapines as Novel and Potent Agents for the Treatment of Glioblastoma. J. Med. Chem. 2025, 68, 247-260.

2. Qiyang Yuan^#, Zhengrong Deng^#, Yi Wan, and Yongqiang Zhang* (通訊作者). Photoredox/Nickel Dual-Catalytic Asymmetric Silylarylation of Alkenes. Org. Lett. 2025, 27, 680-685.

3.Shixun Guo, Wei Wang,* and Yongqiang Zhang* (通訊作者). Radical-Chain Hydrosilylation of Alkenes Enabled by Triplet Energy Transfer. Chem. Eur. J. 2024, 30, e202402051.

4. Defeng Li^#, Chuanxu Liu^#, Tingyu Guo^#, Jiajie Zhu, Jiaqi Guo, Ting Luo, Yuhuan Liu, Wenhao Shen, Biao Jiang, Wei Wang,* Qianqian Yin,* and Yongqiang Zhang*  (通訊作者). Structural Modification of Noscapine via Photoredox/Nickel Dual Catalysis for the Discovery of S?Phase Arresting Agents. ACS Med. Chem. Lett. 2024, 15, 230-238.

5. Haoliang Shi, Yi Wan, and Yongqiang Zhang* (通訊作者). Synthesis of Diverse Oxetane Amino Acids via Visible-Light-Induced Photocatalytic Decarboxylative Giese-Type Reaction. Chin. J. Chem. 2024, 42, 1341-1346.

6.Yumo Zhao, Yi Wan, Qiyang Yuan, Jinlian Wei* and  Yongqiang Zhang* (通訊作者). Photocatalytic C-Si Bond Formations Using Pentacoordinate Silylsilicates as Silyl Radical Precursors: Synthetic Tricks Using Old Reagents. Org. Lett.2023, 25, 1386-1391.

7.Yi Wan, Yumo Zhao, Jiajie Zhu, Qiyang Yuan, Wei Wang* and  Yongqiang Zhang* (通訊作者). Organophotocatalytic Silyl Transfer of Silylboranes Enabled by Methanol Association: A Versatile Strategy for C-Si Bond Construction. Green Chem. 2023, 25, 256-253.

8.Jianhong Zhao, Kun Qian, Mengchao Tong, Qiyang Yuan  and  Yongqiang Zhang* (通訊作者). Mild and Metal-Free Cross-Dehydrogenative Coupling of Nitrogen Heteroarenes with Aldehydes Enabled by Structural Hybridization of Promoting Reagents. ChemistrySelect 2022, 7, e20210417.

9.KaiLin Lu^#,  Yingying Ma^#, Shihui Liu, Shixun Guo  and  Yongqiang Zhang* (通訊作者). Highly Stereoselective C-Glycosylation by Photocatalytic Decarboxylative Alkynylation on Anomeric Position: A Facile Access to Alkynyl C-Glycosides. Chin. J. Chem. 2022, 40, 681-686.

10.Yi Wan, Jiajie Zhu, Qiyang Yuan, Wei Wang* and  Yongqiang Zhang* (通訊作者). Synthesis of β?Silyl α?Amino Acids via Visible-Light-Mediated Hydrosilylation. Org. Lett. 2021, 23, 1406-1410.

11.Xiang Li^#,  Chaoyang Liu^#, Shixun Guo, Wei Wang* and  Yongqiang Zhang* (通訊作者). PIFA-Mediated Cross-Dehydrogenative Coupling of N-Heteroarenes with Cyclic Ethers: Ethanol as an Efficient Promoter. Eur. J. Org. Chem. 2021, 411-421.

12.Jiaqi Guo, Yating Wang, Yuhang Li, Kailin Lu, Shihui Liu, Wei Wang* and  Yongqiang Zhang* (通訊作者). Graphitic Carbon Nitride Polymer as a Recyclable Photoredox Catalyst for Decarboxylative Alkynylation of Carboxylic Acids. Adv. Synth. Catal. 2020, 362, 3898-3904.

13.Huaqiang Fan^#, Yi Wan^#, Peng Pan, Wenbin Cai, Shihui Liu, Chuanxu Liu* and Yongqiang Zhang* (通訊作者). A Cascade Approach to 3D Cyclic Carbamates via An Ionic Decarboxylative Functionalization of Olefinic Oxamic Acids. Chem. Commun. 2020, 56, 86-89.

14. Yingying Ma^#, Shihui Liu^#, Yifan Xi, Hongrui Li, Kai Yang, Zhihao Cheng, Wei Wang* and Yongqiang Zhang*(通訊作者). Highly Stereoselective Synthesis of Aryl/Heteroaryl-C-Nucleosides via the Merger of Photoredox and Nickel Catalysis. Chem. Commun. 2019, 55, 14657-14660.

15. Shihui Liu, Peng Pan, Huaqiang Fan, Hao Li, Wei Wang* and Yongqiang Zhang*(通訊作者). Photocatalytic C–H Silylation of Heteroarenes by Using Trialkylhydrosilanes. Chem. Sci. 2019, 10, 3817-3825.

16. Huaqiang Fan, Peng Pan, Yongqiang Zhang*(通訊作者) and Wei Wang*. Synthesis of 2?Quinolinones via a Hypervalent Iodine(III)-Mediated Intramolecular Decarboxylative Heck-Type Reaction at Room Temperature. Org. Lett. 2018, 20, 7929?7932.

17. Shihui Liu, Aoxia Liu, Yongqiang Zhang*(通訊作者), Wei Wang*. Direct Cα-Heteroarylation of Structurally Diverse Ethers via a Mild N-Hydroxysuccinimide Mediated Cross-Dehydrogenative Coupling Reaction. Chem. Sci. 2017, 8, 4044-4450.

18. Yongqiang Zhang(第一作者), Kevin B. Teuscher, Haitao Ji*. Direct α-Heteroarylation of Amides (α to Nitrogen) and Ethers through a Benzaldehyde -Mediated Photoredox Reaction. Chem. Sci. 2016, 7, 2111–2118.

19. Wenbin Cai, Huaqiang Fan, Dazhong Ding, Yongqiang Zhang*(通訊作者), Wei Wang*. Synthesis of Z-alkenes via Visible Light Promoted Photocatalytic E - Z Isomerization under Metal-Free Conditions. Chem. Commun. 2017, 53, 12918-12921.

20.He Huang, Chenguang Yu, Yueteng Zhang, Yongqiang Zhang, Patrick S. Mariano*, and Wei Wang*. Chemo- and Regioselective Organo-Photoredox Catalyzed Hydroformylation of Styrenes via a Radical Pathway. J. Am. Chem. Soc. 2017, 139, 9799?9802.

博士后期間(2013年-2016年)：

1. Logan R. Hoggard,? Yongqiang Zhang(并列第一作者),?Min Zhang, Vanja Panic, John A. Wisniewski, and Haitao Ji*. Rational Design of Selective Small-Molecule Inhibitors for β?Catenin/B-Cell Lymphoma 9 Protein?Protein Interactions. J. Am. Chem. Soc. 2015, 137, 12249?12260.

2. J. Leon Catrow,? Yongqiang Zhang(并列第一作者),? Min Zhang, and Haitao Ji*. Discovery of Selective Small-Molecule Inhibitors for the β?Catenin/TCell Factor Protein?Protein Interaction through the Optimization of the Acyl Hydrazone Moiety. J. Med. Chem. 2015, 58, 4678?4692.

3.Yongqiang Zhang, Shanchao Wu, Shengzheng Wang, Kun Fang, Guoqiang Dong, Na Liu, Zhenyuan Miao, Jianzhong Yao, Jian Li, Wannian Zhang,* Chunquan Sheng,* and Wei Wang*. Divergent Cascade Construction of Skeletally Diverse “Privileged” Pyrazole-Derived Molecular Architectures. Eur. J. Org. Chem.2015, 2030–2037.

4. Shanchao Wu, ? Yongqiang Zhang(并列第一作者),? Xiaomeng He,? Xiaoying Che, Shengzheng Wang, Yang Liu, Yan Jiang, Na Liu, Guoqiang Dong, Jianzhong Yao, Zhenyuan Miao, Yan Wang, Wannian Zhang,* and Chunquan Sheng*. From Antidiabetic to Antifungal: Discovery of Highly Potent Triazole-Thiazolidinedione Hybrids as Novel Antifungal Agents. ChemMedChem 2014, 9, 2639 – 2646.