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個(gè)人簡介

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        徐文平，1967年2月生，上海徐匯人。博士，教授，研究生導(dǎo)師，農(nóng)業(yè)農(nóng)村部農(nóng)藥生物活性室內(nèi)測試行業(yè)標(biāo)準(zhǔn)的主要起草人。1985年畢業(yè)于上海七寶中學(xué)，1989年畢業(yè)于華東化工學(xué)院（現(xiàn)華東理工大學(xué)）生物化學(xué)專業(yè)，2009年獲南京師范大學(xué)微生物專業(yè)理學(xué)博士學(xué)位。1989年至2009年工作于上海市農(nóng)藥研究所，2010年調(diào)入華東理工大學(xué)藥學(xué)院。1989年至今，先后承擔(dān)和參與了生物農(nóng)藥領(lǐng)域的多個(gè)重要研究項(xiàng)目，包括國家“九五”、“十五”科技攻關(guān)計(jì)劃和“十一五”、“十二五”的科技支撐計(jì)劃課題、“十三五”、“十四五”重點(diǎn)研發(fā)計(jì)劃項(xiàng)目以及上海市政府重點(diǎn)科技攻關(guān)項(xiàng)目等，同時(shí)也承擔(dān)了多項(xiàng)企業(yè)委托課題，獲國內(nèi)外發(fā)明專利授權(quán)30余件，近十年在農(nóng)藥領(lǐng)域國內(nèi)外期刊發(fā)表論文70余篇。

研究方向

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近三年主要論著（2017-2020）

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[1]     Youwu Hao, Yang Zhang, Jiagao Cheng, Wenping Xu, Zhiping Xu, Jufang Gao, Liming Tao*. Adjuvant contributes Roundup's Unexpected Effects on A549 Cells. Environ. Res.2020,184, 109306

       [2]     張頌函，楊星，占秀萍，張樂山，徐文平*. 上海地區(qū)田間菜蚜對啶蟲脒的抗性研究[J]. 農(nóng)藥，2019, 58(07), 540-542.

[3]     Yang Zhang^#, Wei Guo^#, Hui Chen, Jufang Gao, Zhiping Xu, Liming Tao, Zhong Li*, Wenping Xu*. Spinetoram confers its cytotoxic effects by inducing AMPK/mTOR-mediated autophagy and oxidative DNA damage. Ecotoxicol. Environ. Saf. 2019, 183, 109480.

[4]     Yang Zhang^#, Wei Guo^#, Hui Chen, Jufang Gao, Liming Tao, Zhong Li*, Wenping Xu*. The cytotoxic effects of spinetoram on human HepG2 cells by inducing DNA damage and mitochondria-associated apoptosis. Food Agric. Immunol. 2019, 30, 1020-1032.

[5]     Yang Zhang, Yangyang Fan, Jufang Gao, Wenping Xu, Zhiping Xu, Yutian Liu, Zhong Li*, Liming Tao*. A new 24-membered macrolide shows insecticidal activity against Pieris rapae potentially through induction of programmed cell death. Food Agric. Immunol. 2019, 30, 727-742.

[6]     Yang Zhang, Hui Chen, Yangyang Fan, Yun Yang, Jufang Gao, Wenping Xu, Zhiping Xu, Zhong Li*, Liming Tao*. Cytotoxic effects of bio-pesticide spinosad on human lung A549 cells.Chemosphere. 2019, 230, 182-189.

[7]     Yangyang Fan^#, Yang Zhang^#, Yutian Liu, Wenping Xu, Yun Yang, Youwu Hao, Liming Tao*. A natural product enhances apoptosis via mitochondria/caspase-mediated pathway in Hela cells.J. Cell Biochem. 2019, 120(10), 16811-16823.

[8]     Youwu Hao^#, Yang Zhang^#, Hongfei Ni, Jufang Gao, Yun Yang, Wenping Xu, Liming Tao*. Evaluation of the cytotoxic effects of glyphosate herbicides in human liver, lung and nerve. J. Environ Sci. Heal, B. 2019, 54(9), 737-744.

[9]     Youwu Hao^#, Yang Zhang^#, Wenping Xu, Jufang Gao, Liming Tao*. Synergistic effects of adjuvant A-134 on the herbicidal effects of glyphosate. J. Pestic. Sci.2019,44(4), 249-254.

[10]Ping Zhang, Yang Zhang, Kuikui Liu, Bin Liu, Wenping Xu, Jufang Gao, Lei Ding, Liming Tao*. Ivermectin induces cell cycle arrest and apoptosis of HeLa cells via mitochondrial pathway. Cell Proliferat. 2019, 52(2), e12543.

[11]Youwu Hao, Wenping Xu, Jufang Gao, Yang Zhang, Yun Yang, Liming Tao*. Roundup? induced AMPK/mTOR mediated autophagy in human A549 cells. J. Agric. Food Chem.2019,67, 11364-11372.

[12]Youwu Hao, Nan Zhang, Wenping Xu, Jufang Gao, Yang Zhang,Liming Tao*. A natural adjuvant shows the ability to improve the effectiveness of glyphosate application. J. Pestic. Sci.2019,44(2), 106-111.

[13]Youwu Hao, Hui Chen, Wenping Xu, Jufang Gao, Yun Yang, Yang Zhang, Liming Tao*. Roundup? confers cytotoxicity through DNA damage and Mitochondria-Associated apoptosis induction. Environ. Pollut. 2019,252A, 917-923.

[14]Haijing Cao, Wenjing Liu, Yuansen Chang, Hui Chen, Yang Zhang, Wenping Xu, Liming Tao*. 5′-Epi-SPA-6952A, a new insecticidal 24-membered macrolide produced by Streptomyces diastatochromogenes SSPRC-11339. Nat. Prod. Res. 2019, 33(5), 659-664.

[15]Yang Zhang, Yuansen Chang, Haijing Cao, Wenping Xu, Zhong Li, Liming Tao*. Potential threat of chlorpyrifos to human liver cells via the caspase-dependent Mitochondrial Pathways.  Food Agric. Immunol. 2018, 29, 294-305.

[16]Yun Yang, Wenjing Liu, Jian Wang, Yang Zhang, Wenping Xu, Liming Tao*. The different effects of natural pyrethrins and beta-cypermethrin on human hepatocyte QSG7701 cells by ROS-mediated oxidative damage. Environ. Sci. Pollut. R. 2018, 25(24), 24230-24240.

[17]Yun Yang, Jufang Gao, Yang Zhang, Wenping Xu, Youwu Hao, Zhiping Xu, Liming Tao*. Natural pyrethrins induce autophagy of HepG2 cells through the activation of AMPK/mTOR pathway. Environ. Pollut. 2018, 241, 1091-1097.

[18]Wenping Xu^#, Mingjun Yang^#, Jufang Gao, Yang Zhang, Liming Tao*. Oxidative stress and DNA damage induced by spinosad exposure in Spodoptera frugiperda Sf9 cells. Food Agric.Immunol. 2018, 29, 171-181.

       [19]郭俊夫，宗蜜蜜，徐文平，陶黎明*. 海洋鏈霉菌P10-16代謝產(chǎn)物的分離與鑒定[J]. 湖南農(nóng)業(yè)大學(xué)學(xué)報(bào)(自然科學(xué)版)，2017, 43(06), 615-619.

       [20]程亮，羅明明，吳繼綱，郝有武，徐文平，陶黎明*. 海洋放線菌Y12-26中抗真菌活性代謝產(chǎn)物的分離純化與結(jié)構(gòu)鑒定[J]. 中國抗生素雜志，2017, 42(08), 631-638.

       [21]楊韻，盧淼青，張陽，楊明俊，徐文平，陶黎明*. 高效氯氰菊酯對草地貪夜蛾Sf9細(xì)胞自噬的誘導(dǎo)作用[J]. 農(nóng)藥學(xué)學(xué)報(bào)，2017, 19(02), 176-181.

[22]Yang Zhang, Jigang Wu, Wenping Xu, Jufang Gao, Haijing Cao, Mingjun Yang, Bo Wang, Youwu Hao, Liming Tao*. Cytotoxic effects of avermectin on human HepG2 cells in vitro bioassays. Environ. Pollut. 2017, 220, 1127-1137.

[23]Mingjun Yang, Bo Wang, Jufang Gao, Yang Zhang, Wenping Xu, Liming Tao*. Spinosad induces programmed cell death involves mitochondrial dysfunction and cytochrome c release in Spodoptera frugiperda Sf9 cells. Chemosphere. 2017, 169, 155-161.

[24]Yun Yang, Mimi Zong, Wenping Xu, Yang Zhang, Bo Wang, Mingjun Yang, Liming Tao*. Natural pyrethrins induces apoptosis in human hepatocyte cells via Bax- and Bcl-2-mediated mitochondrial pathway. Chem-Biol. Interact. 2017, 262, 38-45.

[25]Wenping Xu^#, Bo Wang^#, Mingjun Yang, Yang Zhang, Zhiping Xu, Yun Yang, Haijing Cao, Liming Tao*. Tebufenozide induces G1/S cell cycle arrest and apoptosis in human cells. Environ. Toxicol Phar. 2017, 49, 89-96.

[26]Youwu Hao, Gaohui Zhou, Wei Wu, Yang Zhang, Liming Tao, Jianhua Yao, Wenping Xu*. Synthesis and antiviral evaluation of novel N-6 substituted adenosine analogues. Tetrahedron Lett. 2017, 58(3), 190-193.

[27]Mingjun Yang, Youwu Hao, Jufang Gao, Yang Zhang, Wenping Xu, Liming Tao*. Spinosad induces autophagy of Spodoptera frugiperda Sf9 cells and the activation of AMPK/mTOR signaling pathway. Comp. Biochem. Physiol. C: Pharmacol. Toxicol. 2017, 195, 52-59.

[28]Wenping Xu^#, Songlin Liu^#, Yang Zhang, Jufang Gao, Mingjun Yang, Xiao Liu, Liming Tao*. Cypermethrin resistance conferred by increased target insensitivity and metabolic detoxification in Culex pipiens pallens Coq. Pestic. Biochem. Physiol. 2017, 142C, 77-82.

[29]Zhiping Xu, Miaoqing Lu, Mingjun Yang, Wenping Xu, Jufang Gao, Yang Zhang, Yun Yang, Liming Tao*. Pyrethrum-extract induced autophagy in Insect cells: A new target? Pestic. Biochem. Physiol. 2017, 137, 21-26.

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1.  CTBS蛋白作為精卵結(jié)合受體的靶點(diǎn)在篩選精卵結(jié)合抑制劑中的應(yīng)用，2013年，中國發(fā)明專利，授權(quán)公告號 CN 103743910 B；

2.地喹氯銨作為鼠類的生育控制藥物的應(yīng)用，2013年，中國發(fā)明專利，授權(quán)公告號CN 103749457 B；