何薇薇，博士
副教授,博導(dǎo)
電話：021-64252293
E-mail: heweiwei@ecust.edu.cn
地址：上海市徐匯區(qū)梅隴路130號(hào)實(shí)驗(yàn)十八樓1219室；郵編：200237
個(gè)人簡(jiǎn)歷：
2007年6月畢業(yè)于中國(guó)科學(xué)技術(shù)大學(xué)，獲碩士學(xué)位，從事生物化學(xué)及結(jié)構(gòu)生物學(xué)研究；隨后赴美，2013年2月畢業(yè)于美國(guó)Scripps研究所，獲博士學(xué)位，從事神經(jīng)肌肉萎縮癥的分子生物學(xué)機(jī)制研究。2014年7月加入華東理工大學(xué)藥學(xué)院，任副教授。2015年入選上海市浦江人才計(jì)劃。作為項(xiàng)目負(fù)責(zé)人，主持了國(guó)家自然科學(xué)基金（青年，面上），并參與科技部“973計(jì)劃”（青年項(xiàng)目）,國(guó)家自然科學(xué)基金國(guó)際(地區(qū))合作與交流項(xiàng)目,NSFC-云南聯(lián)合基金重點(diǎn)支持項(xiàng)目。
研究方向：
致力于活性小分子特別是天然產(chǎn)物靶點(diǎn)識(shí)別與機(jī)制研究。
利用表觀活性良好的天然產(chǎn)物作為工具，
（1）研究與癌癥等疾病密切相關(guān)的細(xì)胞周期、自噬、代謝、蛋白相分離等生命過程；
（2）闡釋分子機(jī)制，揭示疾病發(fā)生發(fā)展機(jī)制，發(fā)現(xiàn)生物學(xué)事件及其關(guān)聯(lián)的契機(jī)；
（3）發(fā)展具有潛在治療意義的小分子調(diào)控劑。
代表性論文：
1. Yan Peng,# Yumeng Zhang,# Ruan Fang,# Hao Jiang,# Gongcai Lan, Zhou Xu, Yajie Liu, Zhaoyang Nie, Lu Ren, Fengcan Wang, Shou-De Zhang, Yuyong Ma, Peng Yang, Hong-Hua Ge, Wei-Dong Zhang,* Cheng Luo,* Ang Li,* and Weiwei He* Target Identification and Mechanistic Characterization of Indole Terpenoid Mimics: Proper Spindle Microtubule Assembly Is Essential for Cdh1-Mediated Proteolysis of CENP-A. Advanced Science 2024, e2305593.
2. Shaonan Wang,# Min Sun,# Yajuan Su, Zhou Xu, Ang Li,* and Weiwei He* Deucravacitinib induces proteasomal degradation of YAP1 in human glioblastoma cells. Synlett 2024, DOI: 10.1055/a-2331-6463.
3. Shaonan Wang,# Yali Wu,# Mengyu Ba, Zhou Xu, Guoxing Gu, William G. Whittingham, Cong Liu, Ang Li,* and Weiwei He* Discovery of the lysosome-inhibiting function of acremolactone B. Synlett 2024, DOI: 10.1055/a-2325-3938.
4. Weiwei He,# Hongbo Zhang,# Xudong Lin, Lili Zhu, Tingting Zheng, Hao Pei, Yang Tian, Min Zhang, Guoyue Shi, Lei Wu, Jianlong Zhao, Gulinuer Wumaier, Shengqing Li, Yufang Xu, Honglin Li,* and Xuhong Qian* Advancements in life-on-a-chip: The impact of “Beyond Limits Manufacturing” technology. Chinese Chemical Letters 2023, 109091.
5. Fan Yang, Jie Zhang, Jiacheng Li, Wenbo Ye, Ang Li,* and Weiwei He* Synthesis of a glucose conjugate of pristimerin and evaluation of its anticancer activity. Chinese Chemical Letters 2022, 34, 107438.
6. Gongcai Lan, Jie Zhang, Wenbo Ye, Fan Yang, Ang Li,* Weiwei He,* and Wei-Dong Zhang* Celastrol as a tool for the study of the biological events of metabolic diseases. Science China Chemistry 2019, 62, 409–416.
7. Jinpeng Pei, Shupeng Zhou, Fan Yang, Yu Sun, Ang Li,* Wei-Dong Zhang,* and Weiwei He* Identification and mechanistic studies of a cell cycle regulator JP18 from a library of synthetic indole terpenoid mimics. Chem. Asian J. 2016, 11, 2715–2718.
8. Zhongyin Zhang, Fan Yang, Jian-Jun Fu, Yun-Heng Shen,* Weiwei He,* and Wei-Dong Zhang* Delavatine A, a structurally unusual cyclopenta[de] isoquinoline alkaloid from Incarvillea delavayi. RSC advances 2016, 6, 65885–65888.
9. Weiwei He,# Ge Bai,# Huihao Zhou, Na Wei, Nicholas M. White, Janelle Lauer, Huaqing Liu, Yi Shi, Calin Dan Dumitru, Karen Lettieri, Veronica Shubayev, Albena Jordanova, Velina Guergueltcheva, Patrick Griffin, Robert W. Burgess, Samuel L. Pfaff,* and Xiang-Lei Yang* CMT2D neuropathy is linked to the neomorphic binding activity of glycyl-tRNA synthetase. Nature 2015, 526, 710–714.
10. Weiwei He,# Hui-Min Zhang,# Yeeting E. Chong, Min Guo, Alan G. Marshall, and Xiang-Lei Yang* Dispersed disease-causing neomorphic mutations on a single protein promote the same localized conformational opening. Proc. Natl. Acad. Sci. USA 2011, 108, 12307–12312.
11. Weiwei He,# Yi Wang,# Wei Liu, and Cong-Zhao Zhou,* Crystal structure of Saccharomyces cerevisiae 6-phosphogluconate dehydrogenase Gnd1. BMC Structural Biology 2007, 7, 38–46.
