楊泱泱，副研究員

博士生導(dǎo)師

Tel：021-64252419,；E-mail：triyang@ecust.edu.cn

招生方向:

  (1)博士:植物保護(hù)

  (2)碩士:藥學(xué)(學(xué)碩,專碩),制藥工程(學(xué)碩)

主要研究方向：

(一) 核酸藥物的設(shè)計,構(gòu)建與應(yīng)用

   利用核酸折紙技術(shù),設(shè)計與構(gòu)建功能化核酸折紙納米材料,實現(xiàn)其在疾病診斷與治療中的應(yīng)用

(二) RNA生物農(nóng)藥(核酸農(nóng)藥)遞送系統(tǒng)的設(shè)計,開發(fā)及應(yīng)用

   針對RNA生物農(nóng)藥的創(chuàng)制瓶頸,開發(fā)RNA生物農(nóng)藥設(shè)計,篩選及遞送的新底盤技術(shù),實現(xiàn)RNA生物農(nóng)藥的高效遞送與應(yīng)用

(三) 納米農(nóng)藥連續(xù)制備工藝與裝備系統(tǒng)開發(fā)

   針對納米農(nóng)藥傳統(tǒng)制備時面臨的粒徑不均一,分散性差,不穩(wěn)定,難以放大生產(chǎn)等問題,利用微納流控技術(shù),開展納米農(nóng)藥連續(xù)制備的配方篩選,工藝開發(fā)以及放大

代表性論文:

1. Yue Liao; Chunyu Fan; Jiaxin Zheng; Caixia Liu; Weiping Zhu; Yufang Xu; Xuhong Qian; Yangyang Yang*, Enhanced liquid–liquid phase separation of stress granules in a reconstructed model and their cytoplasmic targeting using a DNA nanodevice, Journal of Materials Chemistry B, 2025, DOI: 10.1039/D4TB02161D

2. Jianmian Fu; Bin Wang; Weiping Zhu; Yufang Xu; Xuhong Qian; Yangyang Yang*, Feedback-induced phase separation of hollow condensates to create biomimetic membraneless compartments, Journal of Materials Chemistry B, 2025 DOI: 10.1039/D4TB01670J

3. Jinshan Xie; Jiaxin Zhang; Jingyi Yang; Shuqin Wu; Xuanming Teng; Hongyu Han; Yufang Xu; Xuhong Qian; Weiping Zhu*; Yangyang Yang*, Microfluidic-Based dsRNA Delivery Nanoplatform for Efficient Spodoptera exigua Control, Journal of Agricultural and Food Chemistry, 2024, DOI: 10.1021/acs.jafc.4c03307

4. Jingyi Yang; Jiahao Qu; Xuanming Teng; Weiping Zhu; Yufang Xu; Yangyang Yang*; Xuhong Qian, Tumor Microenvironment‐Responsive Hydrogel for Direct Extracellular ATP Imaging‐Guided Surgical Resection with Clear Boundaries, Advanced Healthcare Materials, 2023, DOI: 10.1002/adhm.202301084

5. Caixia Liu; Jingyi Yang; Jiaxin Zheng; Jianmian Fu; Weisi Wang; Liping Duan; Xuhong Qian; Yangyang Yang*, Phase Separation in cGAS‐STING Signaling: Cytosolic DNA Sensing and Regulatory Functions, ChemBioChem, 2023, DOI: 10.1002/cbic.202300147

6. Caixia X. Liu; Bin Wang; Weiping P. Zhu; Yufang F. Xu; Yangyang Y. Yang*; Xuhong H. Qian*, An Endoplasmic Reticulum (ER)‐Targeting DNA Nanodevice for Autophagy‐Dependent Degradation of Proteins in Membrane‐Bound Organelles, Angewandte Chemie International Edition, 2022, DOI: 10.1002/anie.202205509

7. Bin Wang; Honglong Fang; Weiping Zhu; Yufang Xu; Yangyang Yang*; Xuhong Qian*, Dynamic Compartmentalization of Peptide–Oligonucleotide Conjugates with Reversible Nanovesicle–Microdroplet Phase Transition Behaviors, ACS Applied Materials & Interfaces, 2022, DOI: 10.1021/acsami.2c05268

8. Shengtao Yao; Yongyun Chang; Zanjing Zhai; Hiroshi Sugiyama; Masayuki Endo; Weiping Zhu; Yufang Xu*; Yangyang Yang*; Xuhong Qian, DNA-Based Daisy Chain Rotaxane Nanocomposite Hydrogels as Dual-Programmable Dynamic Scaffolds for Stem Cell Adhesion, ACS Applied Materials & Interfaces, 2022, DOI: 10.1021/acsami.2c03265