余星昕 博士
副教授、碩士生導(dǎo)師
聯(lián)系方式
郵箱：xxyu@ecust.edu.cn
傳真：021-64252431
通訊地址：上海市徐匯區(qū)梅隴路130號(hào)318信箱
郵編：200237
個(gè)人簡(jiǎn)介
2012年6月獲復(fù)旦大學(xué)有機(jī)化學(xué)博士學(xué)位，上海市優(yōu)秀畢業(yè)生。畢業(yè)后赴美國(guó)明尼蘇達(dá)大學(xué)(University of Minnesota)藥學(xué)院從事小分子肺癌抑制劑研發(fā)的博士后研究。2013年8月加入華東理工大學(xué)藥學(xué)院，開展藥物小分子設(shè)計(jì)合成及其作用機(jī)制研究。2015年9月晉升副教授，同年被聘為碩士生導(dǎo)師。
作為項(xiàng)目負(fù)責(zé)人，主持國(guó)家自然科學(xué)基金（青年基金），主持教育部基本科研業(yè)務(wù)費(fèi)探索研究基金（2項(xiàng)）；2014年入選上海市“浦江人才計(jì)劃” 和上海市首批“青年科技英才揚(yáng)帆計(jì)劃”；2015年被評(píng)為華東理工大學(xué)“青年英才引進(jìn)與培育計(jì)劃”骨干和2015年度“藥學(xué)院優(yōu)秀青年教師”。
已在Org. Lett.; J. Org. Chem.; Chem. Commun.; Chem. Eur. J.; Chem. Soc. Rev.等國(guó)際核心期刊上發(fā)表SCI論文40余篇，論文被引用1000余次，h指數(shù)22。獲得中國(guó)發(fā)明專利授權(quán)1項(xiàng)。
主要研究方向
基于新技術(shù)、新方法和新反應(yīng)的新型雜環(huán)化合物的設(shè)計(jì)合成，構(gòu)建具有生物活性的類天然小分子化合物用于創(chuàng)新藥物研究。
近期發(fā)表論文
1. Hua Deng,? Renmeng Jia,? Wu-Lin Yang, Xingxin Yu*, Wei-Ping Deng*. Chem. Commun., 2019, 55, 7346-7349. ([?] equal contribution)
Ligand-controlled switch in diastereoselectivities: catalytic asymmetric construction of spirocyclic pyrrolidine-azetidine/oxe(thie)tane derivatives.
2. Jinbin Zhu, Linwei Huang, Wei Dong, Naikai Li, Xingxin Yu, Wei-Ping Deng*, Wenjun Tang*. Angew. Chem. Int. Ed., 10.1002/anie.201910008.
Enantioselective Rhodium-Catalyzed Addition of Arylboroxines to N-Unprotected Ketimines: Efficient Synthesis of Cipargamin.
3. Renmeng Jia, Jiang Meng, Jiaying Leng, Xingxin Yu*, Wei-Ping Deng*. Chem. Asian. J., 2018, 13, 2360-2364.
Rhodium(II)-Catalyzed Reaction of 1-Tosyl-1,2,3-triazoles with Morita-Baylis-Hillman Adducts: Synthesis of 3,4-Fused Pyrroles.
4. Jiang Meng, Renmeng Jia, Jiaying Leng, Min Wen, Xingxin Yu*, Wei-Ping Deng*. Org. Lett., 2017, 19, 4520-4523.
Carbon-Carbon Bond Formation by Reaction of Rhodium Azavinylcarbenes with Secondary Amides: Access to Indigo Analogues from Isatins.
5. Jiang Meng, Min Wen, Shiwei Zhang, Peiwen Pan, Xingxin Yu*, Wei-Ping Deng*. J. Org. Chem., 2017, 82, 1676-1687. (Highlighted by Synfacts, 2017, 13, 354.)
Unexpected O-H Insertion of Rhodium-Azavinylcarbenes with N-Acylhydrazones: Divergent Synthesis of 3,6-Disubstituted- and 3,5,6-Trisubstituted-1,2,4-Triazines.
6. Jiang Meng, Xiangfeng Ding, Xingxin Yu*, Wei-Ping Deng. Tetrahedron, 2016, 72, 176-183.
Synthesis of 2,5-epoxy-1,4-benzoxazepines via rhodium(II)-catalyzed reaction of 1-tosyl-1,2,3-triazoles and salicylaldehydes.
7. Bo Zhou[+], Xingxin Yu[+], Chunlin Zhuang*, Peter Villalta, Yong Lin, Junxuan Lu, Chengguo Xing*. ChemMedChem, 2016, 11, 1436-1445. ([+] equal contribution)
Unambiguous Identification of β-Tubulin as the Direct Cellular Target Responsible for the Cytotoxicity of Chalcone by Photoaffinity Labeling.
8. Linwei Huang, Jinbin Zhu, Guangjun Jiao, Zheng Wang, Xingxin Yu, Wei-Ping Deng*, Wenjun Tang*. Angew. Chem. Int. Ed., 2016, 55, 4527-4531. (Highlighted by Synfacts, 2016, 12, 557.)
Highly Enantioselective Rhodium-Catalyzed Addition of Arylboroxines to Simple Aryl Ketones: Efficient Synthesis of Escitalopram.
9. Fu-Sheng He, Jing-Hai Jin, Zhong-Tao Yang, Xingxin Yu, John S. Fossey, Wei-Ping Deng*. ACS Catal., 2016, 6, 652-656. (Highlighted by Synfacts, 2016, 12, 390.)
Direct Asymmetric Synthesis of β-Bis-Aryl-α-Amino Acid Esters via Enantioselective Copper-Catalyzed Addition of p-Quinone Methides.
10. Wu-Lin Yang, Chun-Yan Li, Wen-Jing Qin, Fei-Fei Tang, Xingxin Yu, Wei-Ping Deng*. ACS Catal., 2016, 6, 5685-5690. (Highlighted by Synfacts, 2016, 12, 1058.)
Cu(I)-Catalyzed Chemoselective and Stereoselective [3+3] Cycloaddition of Azomethine Ylides with 2-Indolylnitroethylenes: Facile Access to Highly Substituted Tetrahydro-γ-Carbolines.
11. Wu-Lin Yang, Fei-Fei Tang, Fu-Sheng He, Chun-Yan Li, Xingxin Yu*, Wei-Ping Deng*. Org. Lett., 2015, 17, 4822-4825. (Highlighted by Synfacts, 2015, 11, 1285.)
Asymmetric Construction of Spirocyclic Pyrrolidine-thia(oxa)zolidinediones via N,O-Ligand/Cu(I) Catalyzed 1,3-Dipolar Cycloaddition of Azomethine Ylides with 5-Alkylidene Thia(oxa)zolidine-2,4-diones.
12. Fu-Sheng He, Han Zhu, Zheng Wang, Ming Gao, Xingxin Yu*, Wei-Ping Deng*. Org. Lett., 2015, 17, 4988-4991. (Highlighted by Synfacts, 2015, 11, 1284.)
Asymmetric Construction of 3,4-Diamino Pyrrolidines via Chiral N,O-Ligand/Cu(I) Catalyzed 1,3-Dipolar Cycloaddition of Azomethine Ylides with β-Phthalimidonitroethene.
13. Zheng Wang[+], Xingxin Yu*[+], Bo-Xue Tian, Daniel T. Payne, Wu-Lin Yang, Yang-Zi Liu, John S. Fossey, Wei-Ping Deng*. Chem. Eur. J., 2015, 21, 10457-10465. ([+] equal contribution)
Chiral N,O-Ligand/Cu(OAc)2 Catalyzed Asymmetric Construction of 4-Aminopyrrolidine Derivativesvia 1,3-Dipolar Cycloaddition of Azomethine Ylides with α-phthalimidoacrylates.
14. Wu-Lin Yang, Yang-Zi Liu, Shuai Luo, Xingxin Yu*, John S. Fossey, Wei-Ping Deng*. Chem. Commun., 2015, 51, 9212-9215. (Highlighted by Synfacts, 2015, 11, 738.)
The copper-catalyzed asymmetric construction of a dispiropyrrolidine skeleton via 1,3-dipolar cycloaddition of azomethine ylides to α-alkylidene succinimides.
15. Fei-Fei Tang, Wu-Lin Yang, Xingxin Yu*, Wei-Ping Deng*. Catal. Sci. Technol., 2015, 5, 3568-3575.
Cu(OAc)2/FOXAP complex catalyzed construction of 2,5-dihydropyrrole derivatives via asymmetric 1,3-dipolar cycloaddition of azomethine ylides with ethynyl ketones.
16. Shan-Shan Jiang, Qin-Chang Xu, Ming-Yu Zhu, Xingxin Yu*, Wei-Ping Deng*. J. Org. Chem., 2015, 80, 3159-3169.
Kinetic Resolution of α-Methylene-β-hydroxy Esters Catalyzed by Acyl Transfer Catalyst An-PIQ.
17. Shan-Shan Jiang, Bo-Qi Gu, Ming-Yu Zhu, Xingxin Yu*, Wei-Ping Deng*. Tetrahedron, 2015, 71, 1187-1191.
Nonenzymatic kinetic resolution of α-aryl substituted allylic alcohols catalyzed by acyl transfer catalyst Np-PIQ.
18. Wen-Jing Qin, Yi Li, Xingxin Yu*, Wei-Ping Deng*. Tetrahedron, 2015, 71, 1182-1186.
TBAI/TBHP catalyzed direct N-acylation of sulfoximines with aldehydes.
19. Jiang Meng, Di Wu, Ying Shi, Xingxin Yu*, Wei-Ping Deng. Tetrahedron, 2015, 71, 1074-1079.
Construction of 1H-pyrrol-2-ylphosphonates via [3+2] cycloaddition of phosphate azomethine ylides with ynones.
20. Xianbo Wang, Xingxin Yu*. J. Org. Chem., 2014, 79, 7854-7860.
Silver(I) and Copper(I) Co-catalyzed Tandem Reaction of 2-Alkynylbenzaldoximes with Aldehydes or Alcohols: Approach to 4-Carboxylated Isoquinolines.
21. Shanshan Jiang, Bin Hu, Xingxin Yu*, Weiping Deng*. Chin. J. Chem., 2014, 32, 694-698.
Fc-PIP Catalyzed Asymmetric Synthesis of cis-2,3-Dihydrobenzofurans.
22. Yong Luo, Xiaolin Pan, Xingxin Yu*, Jie Wu*. Chem. Soc. Rev., 2014, 43, 834-846.
Double Carbometallation of Alkynes: An Efficient Strategy for the Construction of Polycycles.
