楊友 教授，博士生導(dǎo)師

Email: yangyou@ecust.edu.cn

地址：上海市徐匯區(qū)梅隴路130號實(shí)驗(yàn)十八樓1035A室

郵編：200237

課題組網(wǎng)頁：https://www.x-mol.com/groups/Yang_You

        楊友，華東理工大學(xué)教授，博士生導(dǎo)師，國家海外高層次青年人才，山東省泰山產(chǎn)業(yè)創(chuàng)新領(lǐng)軍人才，上海市浦江人才。

        2004年畢業(yè)于中國科學(xué)技術(shù)大學(xué)化學(xué)系，獲理學(xué)學(xué)士學(xué)位；隨后由中國科學(xué)技術(shù)大學(xué)和中國科學(xué)院上海有機(jī)化學(xué)研究所聯(lián)合培養(yǎng)，于2010年獲中國科學(xué)技術(shù)大學(xué)理學(xué)博士學(xué)位；2014年9月至2015年8月，任華東理工大學(xué)藥學(xué)院副教授；2015年9月至今，任華東理工大學(xué)藥學(xué)院教授、博士生導(dǎo)師。

        中國化學(xué)會糖化學(xué)專業(yè)委員會委員、中國生化制藥工業(yè)協(xié)會糖類藥物專家委員會委員、中國疫苗行業(yè)協(xié)會糖疫苗專業(yè)委員會委員、上海市藥學(xué)會藥物化學(xué)專業(yè)委員會委員、國家藥監(jiān)局糖藥物質(zhì)量研究與評價重點(diǎn)實(shí)驗(yàn)室學(xué)術(shù)委員會委員。主要從事糖化學(xué)、糖藥物和糖材料的研究。在ACS. Cent. Sci., Angew. Chem. Int. Ed., J. Am. Chem. Soc.等權(quán)威期刊發(fā)表研究論文50余篇，申請國內(nèi)外發(fā)明專利10余項(xiàng)。獲得中國藥學(xué)會-施維雅青年藥物化學(xué)獎、華東理工大學(xué)青年英才校長獎等獎勵。

研究方向

1. 功能糖的合成和功效評價

2. 糖藥物、糖疫苗和糖材料的開發(fā)

代表性論文

1. Yiyue Zhang?, Xiaotong Wang?, Youling Liang, Liangliang zhang, Jiaohao Fan, You Yang*. A Semisynthetic Oligomannuronic Acid-Based Glycoconjugate Vaccine against Pseudomonas aeruginosa. ACS Cent. Sci. 2024, 10, 1515–1523.

2. Xiaona Li, Cristina Di Carluccio, He Miao, Lvfeng Zhang, Jintao Shang, Antonio Molinaro, Peng Xu,* Alba Silipo,* Biao Yu, and You Yang*. Promoter-Controlled Synthesis and Conformational Analysis of Cyclic Mannosides up to a 32-mer. Angew. Chem. Int. Ed. 2023, 62, e202307851. 

3. Rongkun Liu?, Yan Chen?, Jibin Zheng, Lvfeng Zhang, Tong Xu, Peng Xu, You Yang*. Synthesis of Nucleosides and Deoxynucleosides via Gold(I)-Catalyzed N-Glycosylation of Glycosyl (Z)-Ynenoates. Org. Lett. 2022, 24(51), 9479?9484. 

4. Liangliang Zhang?, Yiyue Zhang?, Qingting Hua, Tong Xu, Junru Liu, Yirong Zhu, You Yang*. Promoter-Controlled Synthesis and Antigenic Evaluation of Mannuronic Acid Alginate Glycans of Pseudomonas aeruginosa. Org. Lett. 2022, 24(45), 8381–8386. 

5. Xiaoqian Li?, Zhi Ma?, Rongkun Liu?, Mattan Hurevich, You Yang*. Photolabile Protecting Group-Mediated Synthesis of 2-Deoxy-Glycosides. Chin. J. Chem. 2021, 39(12), 3309–3314.

6. Junchang Wang?, Yiyue Zhang?, Yirong Zhu, Junru Liu, Yan Chen, Xin Cao, You Yang*. Total Synthesis and Immunological Evaluation of the Tri-D-glycero-D-manno-heptose Antigen of the Lipopolysaccharide as a Vaccine Candidate against Helicobacter pylori. Org. Lett. 2020, 22(22), 8780–8785. 

7. Xiaona Li, Chenyu Li, Rongkun Liu, Jiazhe Wang, Zixuan Wang, Yan Chen, You Yang*. Gold(I)-Catalyzed Glycosylation with Glycosyl Ynenoates as Donors. Org. Lett. 2019, 21(23), 9693?9698. 

8. You Yang*, Biao Yu*. Recent Advances in the Chemical Synthesis of C-Glycosides. Chem. Rev. 2017, 117(19), 12281–12356.

9. Anika Reinhardt?, You Yang?, Heike Claus, Claney L. Pereira, Andrew D. Cox, Ulrich Vogel, Chakkumkal Anish*, Peter H. Seeberger*. Antigenic Potential of a Highly Conserved Neisseria meningitidis Lipopolysaccharide Inner Core Structure Defined by Synthetic Approach. Chem. Biol. 2015, 22(1), 38–49.

10. You Yang, Shunsuke Oishi, Christopher E. Martin, Peter H. Seeberger*. Diversity-oriented Synthesis of Inner Core Oligosaccharides of the Lipopolysaccharide of Pathogenic Gram-negative Bacteria. J. Am. Chem. Soc. 2013, 135(16), 6262–6271. 

11. You Yang, Christopher E. Martin, Peter H. Seeberger*. Total Synthesis of the Core Tetrasaccharide of Neisseria meningitidis Lipopolysaccharide, a Potential Vaccine Candidate for Meningococcal Diseases. Chem. Sci. 2012, 3(3), 896–899. 

12. You Yang, Yao Li, Biao Yu*. Total Synthesis and Structure Revision of TMG-chitotriomycin, a Specific Inhibitor of Insect and Fungal β-N-Acetylglucosaminidases. J. Am. Chem. Soc. 2009, 131(34), 12076–12077.