黃瑾 教授/博導(dǎo)
聯(lián)系方式：
電話: 021-64253681
辦公室：華東理工大學(xué)實(shí)驗(yàn)18樓625
E-mail: huangjin@ecust.edu.cn
招生專(zhuān)業(yè)：藥學(xué)一級(jí)學(xué)科（博士/學(xué)碩/專(zhuān)碩）, 生物與醫(yī)藥（專(zhuān)博/專(zhuān)碩）
歡迎有志于藥理學(xué)、化學(xué)生物學(xué)、新藥開(kāi)發(fā)研究的優(yōu)秀學(xué)生加入！！
本課題組長(zhǎng)期招收博士研究生及博士后
個(gè)人簡(jiǎn)介：
本科畢業(yè)于四川大學(xué)，于南京大學(xué)獲博士學(xué)位，現(xiàn)為華東理工大學(xué)藥學(xué)院教授，博士生導(dǎo)師。作為項(xiàng)目負(fù)責(zé)人，承擔(dān)了國(guó)家自然科學(xué)基金面上項(xiàng)目、上海市科委生物醫(yī)藥專(zhuān)項(xiàng)等多項(xiàng)研究計(jì)劃。上海市藥學(xué)會(huì)藥理學(xué)專(zhuān)業(yè)委員會(huì)委員，中國(guó)中醫(yī)藥信息學(xué)會(huì)中醫(yī)臨床藥學(xué)分會(huì)常務(wù)理事，擔(dān)任Pharmacological Research、中國(guó)癌癥防治雜志 期刊編委。
上海市一流本科課程《藥物化學(xué)生物學(xué)》負(fù)責(zé)人，獲中國(guó)石油教育學(xué)會(huì)石油高等教育教學(xué)成果獎(jiǎng)一等獎(jiǎng)、上海市高校優(yōu)秀教學(xué)成果二等獎(jiǎng)等獎(jiǎng)項(xiàng)。
主要研究方向：
1) 抗腫瘤藥物靶標(biāo)發(fā)現(xiàn)；
2) 抗腫瘤藥物藥理；
3) 高效藥物篩選平臺(tái)構(gòu)建。
入選人才計(jì)劃：
1) 上海市東方英才拔尖計(jì)劃，2024年
2) 上海市浦江人才，2007年
學(xué)生培養(yǎng)：
本課題組以分子藥理學(xué)為基礎(chǔ)，開(kāi)展高效藥物篩選平臺(tái)構(gòu)建，抗腫瘤藥物作用靶標(biāo)確證及藥物發(fā)現(xiàn)相關(guān)研究，具體工作涵蓋藥理學(xué)、藥物篩選、藥物化學(xué)生物學(xué)等方面的研究，研究對(duì)象從蛋白質(zhì)、基因、細(xì)菌、酵母、動(dòng)物細(xì)胞直到活體動(dòng)物都可能涉及，歡迎追求卓越的同學(xué)加盟本實(shí)驗(yàn)室。
經(jīng)過(guò)三年或五年的培養(yǎng)，學(xué)生在分子克隆構(gòu)建、信號(hào)通路分析、蛋白表達(dá)純化、蛋白結(jié)晶及三維結(jié)構(gòu)解析、紫外可見(jiàn)吸收光譜、穩(wěn)態(tài)與瞬態(tài)熒光光譜、共聚焦顯微成像、超分辨成像、熒光生物標(biāo)記等方面有較好的培訓(xùn)。
研究成果發(fā)表在Nature Communications、Haematologica、Oncogene、Journal of Medicinal Chemistry等領(lǐng)域高影響期刊。課題組培養(yǎng)的多個(gè)研究生曾獲國(guó)家獎(jiǎng)學(xué)金、上海市優(yōu)秀畢業(yè)生、中國(guó)藥理學(xué)會(huì)青年藥理學(xué)家獎(jiǎng)等榮譽(yù)稱(chēng)號(hào)。
代表性論文：
1. Fei Pan, Zhaomin Xu, Zehui Liu, Caiyue Chen, Jingwei Yu, Zengrui Wu, Ze Wang, Long Chen, Chengyuan Yue, Weihua Li, Guixia Liu, Jin Huang*, Yun Tang*. ComplexDnet: A Network-Based Strategy to Discover Critical Targets and Screen Active Compounds for Complex Diseases. Journal of Medicinal Chemistry. 2025, 68(18): 19463-19481.
2. Ning Tian, Haoyu Ju, Qian Hu, Qifeng Hou, Yiping Lu, Yu Liu, Jinmei Huang, Zhonghong Zhu, Bin Zhang, Jin Huang*, Minghua Zeng*. Solvothermal domino synthesis of an ER-targeted iron(II) complex for inducing immunogenic cell death. Chinese Chemical Letters. 2025, 10.1016/j.cclet.2025.111038.
3. Weiqiang Lu*, Jiayan Cui, Wanyan Wang, Qian Hu, Yun Xue, Xi Liu, Ting Gong, Yiping Lu, Hui Ma, Xinyu Yang, Bo Feng, Qi Wang, Naixia Zhang, Yechun Xu, Mingyao Liu, Ruth Nussinov, Feixiong Cheng, Hongbin Ji, Jin Huang*. PPIA dictates NRF2 stability to e lung cancer progression. Nature Communications. 2024, 15: 4703.
4. Hui Ma, Jiayan Cui, Zehui Liu, Wenqing Fang, Sisi Lu, Shuying Cao, Yuanyuan Zhang, Ji-An Chen, Lixue Lu, Qiong Xie, Yonghui Wang, Ying Huang, Kongfei Li, Hongyan Tong, Jin Huang*, Weiqiang Lu*. Blockade of de novo pyrimidine biosynthesis triggers autophagic degradation of oncoprotein FLT3-ITD in acute myeloid leukemia. Oncogene. 2023, 42(45): 3331-3343.
5. Xiangli He, Jiayan Cui, Hui Ma, Naijipu Abuduaini, Ying Huang, Lu Tang, Wanyan Wang, Yuanyuan Zhang, Yang Wang, Weiqiang Lu*, Bo Feng*, Jin Huang*. Berberrubine is a novel and selective IMPDH2 inhibitor that impairs the growth of colorectal cancer. Biochemical Pharmacology. 2023, 218: 115868.
6. Ji-An Chen, Hui Ma, Zehui Liu, Jinlong Tian, Sisi Lu, Wenqing Fang, Shuyin Ze, Weiqiang Lu, Qiong Xie*, Jin Huang*, Yonghui Wang*. Discovery of Orally Available Retinoic Acid Receptor-Related Orphan Receptor γ-t/Dihydroorotate Dehydrogenase Dual Inhibitors for the Treatment of Refractory Inflammatory Bowel Disease. Journal of Medicinal Chemistry. 2022, 65(1): 592-615.
7. Zengrui Wu, Hui Ma, Zehui Liu, Lulu Zheng, Zhuohang Yu, Shuying Cao, Wenqing Fang, Lili Wu, Weihua Li, Guixia Liu, Jin Huang*, Yun Tang*. wSDTNBI: a novel network-based inference method for virtual screening. Chemical Science. 2022, 13(4): 1060-1079.
8. Xi Liu, Qian Hu, Wanyan Wang, Hui Ma, Jiaqian Pu, Jiayan Cui, Ting Gong, Yu Wu, Weiqiang Lu*, Jin Huang*. A protein-fragment complementation assay reveals that celastrol and gambogic acid suppress ERα mutants in breast cancer. Biochemical Pharmacology. 2021, 188: 114583.
9. Wanyan Wang, Jiayan Cui, Hui Ma, Weiqiang Lu, Jin Huang*. Targeting Pyrimidine Metabolism in the Era of Precision Cancer Medicine. Frontiers In Oncology. 2021, 11: 684961.
10. Wanyan Wang, Yu Wu, Si Chen, Xi Liu, Jiacheng He, Shuyi Wang, Weiqiang Lu*, Yong Tang*, Jin Huang*. Shikonin is a novel and selective IMPDH2 inhibitor that target triple-negative breast cancer. Phytotherapy Research. 2021, 5(1): 63-476.
11. Zehui Liu, Qian Hu, Wanyan Wang, Sisi Lu, Dang Wu, Shuyin Ze, Jiacheng He, Ying Huang, Wuyan Chen, Yechun Xu, Weiqiang Lu*, Jin Huang*. Natural product piperine alleviates experimental allergic encephalomyelitis in mice by targeting dihydroorotate dehydrogenase. Biochemical Pharmacology. 2020, 177: 114000.
12. Zhonghong Zhu, Qian Hu, Huiling Pan, Yuexing Zhang, Haibing Xu, Mohamedally Kurmoo, Jin Huang*, Minghua Zeng*. Tracking the multiple step formation of an iron(III) complex and its application in photodynamic therapy for breast cancer. Science China-Chemistry. 2019, 62(6): 719-726.
13. Xueyuan Wu, Mingbo Wang, Yaqian Wang; Mengyin Li, Yilun Ying, Jin Huang*, Yitao Long*. Precise Construction and Tuning of an Aerolysin Single-Biomolecule Interface for Single Molecule Sensing. CCS Chemistry, 2019, 1: 304-312.
14. Dang Wu, Wanyan Wang, Wuyan Chen, Fulin Lian, Li Lang, Ying Huang, Yechun Xu, Naixia Zhang, Yinbin Chen, Mingyao Liu, Ruth Nussinov, Feixiong Cheng*, Weiqiang Lu*, Jin Huang*. Pharmacological inhibition of dihydroorotate dehydrogenase induces apoptosis and differentiation in acute myeloid leukemia cells. Haematologica. 2018, 103(9): 1472-1483.
15. Weiqiang Lu, Feixiong Cheng, Wenzhong Yan, Xi Li, Xue Yao, Wenqiang Song, Mingyao Liu, Xu Shen, Hualiang Jiang, Jing Chen, Jian Li*, Jin Huang*. Selective targeting p53WT lung cancer cells harboring homozygous p53 Arg72 by an inhibitor of CypA. Oncogene. 2017, 36(33): 4719-4731.
16. Weiqiang Lu, Xue Yao, Ping Ouyang, Ningning Dong, Dang Wu, Xingwu Jiang, Zengrui Wu, Chen Zhang, Zhongyu Xu, Yun Tang, Shien Zou, Mingyao Liu, Jian Li, Minghua Zeng, Ping Lin, Feixiong Cheng*, Jin Huang*. Drug Repurposing of Histone Deacetylase Inhibitors That Alleviate Neutrophilic Inflammation in Acute Lung Injury and Idiopathic Pulmonary Fibrosis via Inhibiting Leukotriene A4 Hydrolase and Blocking LTB4 Biosynthesis. Journal of Medicinal Chemistry. 2017, 60(5): 1817-1828.
