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朱維平
發(fā)布時間:2014-08-29   訪問次數(shù):24923   作者:

 

 

朱維平 教授  博士生導(dǎo)師,上海領(lǐng)軍人才


電話:  021-64253822

地址:  上海市梅隴路130號華東理工大學(xué)實(shí)驗(yàn)18樓1507室
E-mail: wpzhu@ecust.edu.cn  
 

個人簡介

朱維平,男,華東理工大學(xué)藥學(xué)院教授,博士生導(dǎo)師,上海領(lǐng)軍人才。1967年生于江蘇揚(yáng)中。1989.7畢業(yè)于國防科技大學(xué)應(yīng)用化學(xué)專業(yè),獲工學(xué)學(xué)士學(xué)位;1992.7畢業(yè)于華東化工學(xué)院(現(xiàn)華東理工大學(xué))精細(xì)化工專業(yè),獲工學(xué)碩士學(xué)位;2004.6畢業(yè)于華東理工大學(xué)化學(xué)工程專業(yè),獲工學(xué)博士學(xué)位。1992.7-1999.9揚(yáng)子石化研究院工程師、副所長;1999.10-2005.1揚(yáng)子石化研究院高級工程師、副所長、所長;2005.2-2010.8,華東理工大學(xué)藥學(xué)院副教授;2010.9至今,華東理工大學(xué)教授。2009.2-2010.1,美國加州大學(xué)洛杉磯分校訪問學(xué)者;2016.2-2016.8,美國斯坦福大學(xué)醫(yī)學(xué)院訪問學(xué)者。主要從事原料藥連續(xù)流動合成、納米藥物遞送系統(tǒng)構(gòu)建、微納流控芯片研制等方面的研究。近年來,作為負(fù)責(zé)人承擔(dān) “超限制造上海市科技重大專項(xiàng)、國家重點(diǎn)研發(fā)計(jì)劃、國家自然科學(xué)基金等項(xiàng)目(課題)10余項(xiàng)。在《美國化學(xué)會志》《德國應(yīng)用化學(xué)》《生物活性材料》《美國化學(xué)工程師雜志》等國際高影響力刊物發(fā)表通訊作者論文70余篇,獲中國發(fā)明專利授權(quán)31項(xiàng),獲教育部自然科學(xué)一等獎1項(xiàng)。

 

研究方向


(一)藥物連續(xù)流動合成。針對藥物制造過程中面臨的安全、環(huán)保及成本等瓶頸,開展藥物連續(xù)流動合成技術(shù)及反應(yīng)動力學(xué)研究,研制新一代微納化工反應(yīng)器。

(二)新型藥物控制釋放系統(tǒng)的構(gòu)建。針對生物大分子藥物(如胰島素、抗體藥物、siRNA等)、難溶性藥物的體內(nèi)輸送,設(shè)計(jì)各類微環(huán)境和/或刺激響應(yīng)型控制釋放系統(tǒng),實(shí)現(xiàn)藥物分子的可控、靶向給藥。

 

近五年代表性論文

 

1.      Zhixiao Xiong, Yuxin Wu, Shanni Qiu, Yufang Xu, Weiping Zhu*, Xuhong Qian. Construction of naphthalimide-based near-infrared hemicyanine fluorophore and its application for in vivo bioimaging. Dyes and Pigments, 2025, DOI:10.1016/J.DYEPIG.2025.112913

2.      Lu Rao,Xin Zhang,Peiwen Liu, Wei Tao Dou, Hong Yu Lin, Fang Zhao, Weiping Zhu*,Xuhong Qian*,Hai Bo Yang,Lin Xu*. Regulating and Deciphering the Selective Synthesis of Metallacages in Microdroplets. Journal of the American Chemical Society, 2025, 147(35), 31618-31629.

3.      Tongxia Jin,Luling Wu, Ti Jia,Rongrong Zhao, Chusen Huang*,Mengfang Tang,Weiping Zhu*,Yufang Xu,Tony D. James,Xuhong Qian. Simultaneous tracing of protein vicinal dithiols in live cells using an “off-on” fluorescent probe. Sensors and Actuators B: Chemical, 2025, 436, 137685.

4.      Wenqian Xing, Ting Li, Guangze Yang, Shuqin Wu, Bailu Pang, Yufang Xu, Xuhong Qian, Weiping Zhu*. Thermo-Responsive Gold Nanorod Vesicles for Combined NIR-II Photothermal Therapy and Chemotherapy of Solid Tumors. Acta Biomaterialia, 2024, DOI: 10.1016/j.actbio.2024.11.035

5.      Ting Li, Di Cheng, Xiu Xu, Bin Wang, Wenqian Xing, Yufang Xu, Xuhong Qian, Youjun Yang, Weiping Zhu*. Transferrin-targeting pH-responsive and biodegradable mesoporous silica nanohybrid for nitric oxide-sensitized chemotherapy of cancer. Colloids and Surfaces B: Biointerfaces, 2024, DOI: 10.1016/ j.colsurfb.2024.114409

6.      Hui Jin, Mengyu Cui, Peiwen Liu, Zhuo Wang, Tongxia Jin, Yonghui Yang, Weiping Zhu* and Xuhong Qian. A novel magnetic nanoparticle as an efficient and recyclable heterogeneous catalyst for the Suzuki cross-coupling reaction.     React. Chem. Eng., 2024, DOI: 10.1039/d4re00226a

7.      Peiwen Liu, Weiping Zhu*, Fang Zhao*. Modeling and experimental study on a photochemical microscale continuous oscillatory baffled reactor. AIChE J.2024, e18553. DOI: 10.1002/aic.18553

8.      Zhixiao Xiong, Shanni Qiu, Yuyu Wang, Houna Duan, Yi Xiao, Yufang Xu, Weiping Zhu*, Xuhong Qian. Photocalibrated NO release from the zinc ion fluorescent probe based on naphthalimide and its application in living cells. Chinese Chemical Letters. 2024,DOI: 10.1016/j.cclet.2024.110002

9.      Tongxia Jin+, Kai Zeng+, Xin Zhang, Wei-Tao Dou*, Lianrui Hu*, Dawei Zhang*, Weiping Zhu, Xuhong Qian, Hai-Bo Yang, and Lin Xu. Efficient Self-Sorting Behaviours of Metallacages with Subtle Structural Differences. Angew. Chem. Int. Ed. 2024, e202409878. DOI: 10.1002/anie.202409878

10.   Yan Chen, Yongcheng Sun, Yufang Xu, Xuhong Qian, and Weiping Zhu*. Fully Continuous Flow Synthesis of 2′-Deoxy-2′-fluoro-arabinoside: A Key Intermediate of Azvudine. Org. Process Res. Dev.2024, 28(8), 3273-3283.

11.   Haohui Yan,Yan Chen, Peiwen Liu, Weiping Zhu* and Fang Zhao*. Reliable sizing-up of the 3D curved circular microchannel reactor for continuous flow synthesis of a zidovudine intermediate. React. Chem. Eng., 2024, 9(10), 2750-2761.

12.   Jinshan Xie, Jiaxin Zhang, Jingyi Yang, Shuqin Wu, Xuanming Teng, Hongyu Han, Yufang Xu, Xuhong Qian, Weiping Zhu* and Yangyang Yang*. Microfluidic-Based dsRNA Delivery Nanoplatform for Efficient Spodoptera exigua Control. J. Agric. Food Chem.2024, 72(22), 12508-12515.

13.   Yuexiang Liu, Xiangqiao Yang, Tong Lin, Guantian Yang, Xiaoyong Xu, Bubing Zeng, Zhong Li, Weiping Zhu*, Xuhong Qian*. Efficient continuous synthesis of 2-[3-(trifluoromethyl)phenyl]malonic acid, a key intermediate of Triflumezopyrim, coupling with esterification-condensation-hydrolysis. Chinese Chemical Letters,2024, DOI: 10.1016/j.cclet.2024.109747

14.   Peiwen Liu, Fang Zhao, Jing Zhang, Yunpeng Bai, Jinxing Ye, Bo Bao, Xinggui Zhou, Li Zhang, Changlu Zhou, Xinhai Yu, Peng Zuo, Jianye Xia, Lian Cen, Yangyang Yang, Guoyue Shi, Lin Xu, Weiping Zhu*, Yufang Xu, Xuhong Qian*. Micro/nano flow chemistry by Beyond Limits Manufacturing, Chinese Chemical Letters, 2024, DOI: 10.1016/j.cclet.2023.109020

15.   Peiwen Liu, Hui Jin, Yan Chen, Derong Wang, Haohui Yan, Mingzhao Wu, Fang Zhao*, Weiping Zhu*. Process analytical technologies and self-optimization algorithms in automated pharmaceutical continuous manufacturing, Chinese Chemical Letters, 2024, DOI: 10.1016/j.cclet.2023.108877

16.   Hui Jin, Qin Cai, Peiwen Liu, Yan Chen, Derong Wang, Weiping Zhu*, Yufang Xu, Xuhong Qian*. Multistep continuous flow synthesis of Erlotinib, Chinese Chemical Letters, 2024, DOI: 10.1016/j.cclet.2023.108721

17.   Wenqian Xing, Yao Tang, Yuejia Ji, Di Cheng, Bin Wang, Yun Fu, Yufang Xu, Xuhong Qian, XH, Weiping Zhu*. Engineering near-infrared laser-activated gold nanorod vesicles with upper critical solution temperature for photothermal therapy and chemotherapy, Journal of Colloid and Interface Science, 2023, 640, 41-51

18.   Yonghui Yang, Xiayu Shi, Zhuo Chen*, Yufang Xu, Xuhong Qian, Weiping Zhu*. Novel seven-membered ring-fused naphthalimide derivatives with potentials for cancer theranostics, Chinese Chemical Letters, 2023, 34, 107695

19.   Caixia Liu, Bin Wang, Weiping Zhu, Yufang Xu, Yangyang Yang*, Xuhong Qian*. An Endoplasmic Reticulum (ER)-Targeting DNA Nanodevice for Autophagy-Dependent Degradation of Proteins in Membrane-Bound Organelles. Angewandte Chemie International Edition. 2022, https://doi.org/10.1002/anie.202205509

20.   Bin Wang, Honglong Fang, Weiping Zhu, Yufang Xu, Yangyang Yang*, and Xuhong Qian*. Dynamic Compartmentalization of Peptide-Oligonucleotide Conjugates with Reversible Nanovesicle-Microdroplet Phase Transition Behaviors. ACS Applied Materials & Interfaces 2022, 14(32), 36998–37008

21.   Tongxia JinDi ChengGuanyu JiangWenqian XingPeiwen LiuBin WangWeiping Zhu*Haitao Sun*Zhenrong Sun, Yufang XuXuhong Qian* . Engineering naphthalimide-cyanine integrated near-infrared dye into ROS-responsive nanohybrids for tumor PDT/PTT/chemotherapy. Bioactive Materials, 2022, 14, 42–51.

22.   Ling Zhang, Youtian Fu, Yi Shen, Chengyu Liu, Maolin Sun, Ruihua Cheng, Weiping Zhu, Xuhong Qian, Yueyue Ma* Jinxing Ye*. Ritter-type amination of C(sp3)-H bonds enabled by electrochemistry with SO42?. Nature Communications,2022, 13, 4138.

23.   Jiahao Qu. Jing Li. Weiping Zhu. Yufang Xu. Shengmin Zhou*. Yangyang Yang*. Xuhong Qian. Hybrid nanocomposite multinetwork hydrogel containing magnesium hydroxide nanoparticles with enhanced antibacterial activity for wound dressing applications. Polymer, 2022, 251(3), 124902.

24.   Shengtao Yao, Yongyun Chang, Zanjing Zhai, Hiroshi Sugiyama, Masayuki Endo, Weiping Zhu, Yufang Xu, Yangyang Yang*, and Xuhong Qian* DNA-Based Daisy Chain Rotaxane Nanocomposite Hydrogels as Dual-Programmable Dynamic Scaffolds for Stem Cell Adhesion. ACS Applied Materials & Interfaces,2022, 14(18), 20739–20748

25.   Yuejia Ji, Yuxin Sun, Mingyang Hei, Di Cheng, Bin Wang, Yao Tang, Yun Fu, Weiping Zhu*, Yufang Xu, and Xuhong Qian. NIR Activated Upper Critical Solution Temperature Polymeric Micelles for Trimodal Combinational Cancer Therapy. Biomacromolecules, 2022, 23(3), 937–947.

26.   Shengtao Yao. Yue Liao. Rizhao Pan. Weiping Zhu. Yufang Xu*. Yangyang Yang*. Xuhong Qian*. Programmed co-assembly of DNA-peptide hybrid microdroplets by phase separation. Chinese Chemical Letters, 2022, 33(3), 1545-1549

27.   Rongkun Jiang, Xiao Xue, Fang Zhao, Weiping Zhu*, Minjing Shang, Yuanhai Su*, Yufang Xu, Xuhong Qian. Process parameter and kinetic study for the azidation of a zidovudine intermediate with sodium azide in microreactors. Chemical Engineering Journal, 2022, 429, 132207.

28.   Yun Fu, Yuxin Sun, Meng Chen, Wenqian Xing, Yufang Xu, Xuhong Qian, and Weiping Zhu*.  Glycopolymer Nanoparticles with On-Demand Glucose-Responsive Insulin Delivery and Low-Hypoglycemia Risks for Type 1 Diabetic Treatment. Biomacromolecules, 2022, 23(3), 1251–1258 .

29.   Yun Fu, Peng Liu, Meng Chen, Tongxia Jin, Huijing Wu, Mingyang Hei, Congrong Wang, Yufang Xu, Xuhong Qian, Weiping Zhu*. On-demand transdermal insulin delivery system for type 1 diabetes therapy with no hypoglycemia risks. Journal of Colloid and Interface Science,2022, 605, 582–591

30.   Tongxia Jin, Mengyu Cui, Dan Wu, Weiping Zhu*, Yufang Xu, Xuhong Qian. NCL-based mitochondrial-targeting fluorescent probe for the detection of Glutathione in living cells. Chinese Chemical Letters, 2021, 32, 3899-3902

31.   Di Cheng, Yuejia Ji, Bin Wang, Yuyu Wang, Yao Tang, Yun Fu, Yufang Xu, Xuhong Qian, Weiping Zhu*, Dual-responsive nanohybrid based on degradable silica-coated gold nanorods for triple-combination therapy for breast cancer. Acta Biomaterialia,2021, 128, 435-446.

32.   Di Cheng, Yuejia Ji, Bin Wang, Tongxia Jin, Yufang Xu, Xuhong Qian, Weiping Zhu*. Enzyme/GSH dual-responsive biodegradable nanohybrid for spatiotemporally specific photodynamic and hypoxia-augmented therapy against tumors. International Journal of Pharmaceutics, 2021, 603, 120730

33.   Bin Wang, Rizhao Pan, Weiping Zhu, Yufang Xu, Ye Tian, Masayuki Endo, Hiroshi Sugiyama, Yangyang Yang*, Xuhong Qian. Short intrinsically disordered polypeptide-oligonucleotide conjugates for programmed self-assembly of nanospheres with temperature-dependent size controllability. Soft Matter, 2021, 17, 1184-1188

34.   Liyang Cui, Arvin M. Gouw, Edward L. LaGory, Shenghao Guo, Nabeel Attarwala, Yao Tang, Ji Qi, YunSheng Chen, Zhou Gao, Kerriann M. Casey, Arkadiy A. Bazhin, Min Chen, Leeann Hu, Jinghang Xie, Mingxi Fang, Cissy Zhang, Qihua Zhu, Zhiyuan Wang, Amato J. Giaccia, Sanjiv Sam Gambhir, Weiping Zhu, Dean W. Felsher, Mark D. Pegram, Elena A. Goun, Anne Le, Jianghong Rao*, Mitochondrial copper depletion suppresses triple-negative breast cancer in mice. Nature Biotechnology, 2020, 39, 357-367.

35.   Xiaoqin Wei, Tongxia Jin, Chusen Huang*, Nengqing Jia, Weiping Zhu*, Yufang Xu, Xuhong Qian, Monoarsenical-based chemical approaches for exploration of endogenous vicinal-dithiol-containing proteins (VDPs): From the design to their biological application, Coordination Chemistry Reviews, 2020, 429, 213621.

36.   Tongxia Jin, Chusen Huang*, Mengyu Cui, Yonghui Yang, Zhuo Wang, Weiping Zhu*Xuhong Qian, Supramolecular ensembles modified by near-infrared dyes and their biological applicationsJ. Mater. Chem. B, 2020, 8, 10686-10699.

37.   Yuyu Wang, Houna Duan, Hongyuan Shi*, Shiwei Zhang, Yufang Xu, Weiping Zhu*, Xuhong Qian. A highly sensitive fluorescent probe for tracking intracellular zinc ions and direct imaging of prostatic tissue in mice, Chinese Chemical Letters, 2020, 31(11), 2933-2936.

38.   Yao Tang, Yuejia Ji, Chenglin Yi, Di Cheng, Bin Wang, Yun Fu, Yufang Xu, Xuhong Qian, Yahya E. Choonara, Viness Pillay, Weiping Zhu*, Yunen Liu*, Zhihong Nie*. Self-accelerating H2O2-responsive plasmonic nanovesicles for synergistic chemo/starving therapy of tumors, Theranostics, 2020, 10(19), 8691-8704

 




 
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