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張敏
發(fā)布時(shí)間:2015-01-08   訪問次數(shù):13470   作者:張敏

 

 

張敏,博士,副教授

 

聯(lián)系方式

電話:+86-21-6425 3329

電郵:zhangm@ecust.edu.cn

 

 

個(gè)人簡介
    2003年畢業(yè)于華東理工大學(xué)制藥工程專業(yè)(主修)和科技英語專業(yè)(輔修),2008年獲華東理工大學(xué)制藥工程與技術(shù)博士學(xué)位,導(dǎo)師羅國安教授、王義明教授。2004.5-2008.5年在清華大學(xué)化學(xué)系羅國安教授實(shí)驗(yàn)室完成博士論文研究工作;2007.11-2008.4在英國Brunel University Prof. Ian Sutherland和Prof. Svetlana Ignatova課題組開展天然藥用植物活性成分分離方法研究;2012.12至2013.12在美國National Institutes of Health Dr. Yoichiro Ito實(shí)驗(yàn)室進(jìn)行高速逆流色譜技術(shù)合作研究,同期在美國National Institute of Standards and Technology Dr. Ming Zheng實(shí)驗(yàn)室開展碳納米管的相關(guān)研究。2008.7起任職于華東理工大學(xué)藥學(xué)院,先后主持國家自然科學(xué)基金青年和面上項(xiàng)目、上海自然科學(xué)基金項(xiàng)目和中央高校基本科研業(yè)務(wù)費(fèi)探索基金等課題,參與國家自然科學(xué)基金面上項(xiàng)目、上海科委國際合作項(xiàng)目、科技部新藥創(chuàng)制重大專項(xiàng)等課題。
  
研究方向
主要集中在藥物分析領(lǐng)域:
(1)中藥有效成分的原位高效獲取
        以擴(kuò)張床色譜和高速逆流色譜為主要技術(shù)手段,對傳統(tǒng)中藥材中溫敏及光敏性成分進(jìn)行原位高效提取和分離,制備高純度的目標(biāo)化合物。
(2)生物標(biāo)志物的靈敏檢測
        基于金納米顆粒和手性單壁碳納米管等材料,實(shí)現(xiàn)對疾病相關(guān)生物標(biāo)志物的靈敏檢測。
 
招生專業(yè)

制藥工程(碩士)

  

最新進(jìn)展

Y. Li, F.F. Cai, M. Zhang*, H.Y. Zhang, Y.R. Wang, P. Hu*. Two-stage fractionation of polar alkaloids from Rhizoma coptidis by countercurrent chromatography considering the strategy of reactive extraction. Journal of Chromatography A. 2015, 1378: 58-64.

 

代表性論文

(*corresponding author)

Journal Papers 

(21)  F.F. Cai, Y. Li, M. Zhang*, H.Y. Zhang, Y.R. Wang, P. Hu*. Combination of integrated expanded bed adsorption chromatography and countercurrent chromatography for direct extraction and purification of pseudohypericin and hypericin from St. John’s wort (Hypericum perforatum L.). Jounal of Separation Science.  2015, 38 (15): 2588–2596;

(20) Y. Li, F.F. Cai, M. Zhang*, H.Y. Zhang, Y.R. Wang, P. Hu*. Two-stage fractionation of polar alkaloids from Rhizoma coptidis by countercurrent chromatography considering the strategy of reactive extraction. Journal of Chromatography A. 2015, 1378: 58-64;

(19) M. Zhang, C.Y. Khripin, J.A. Fagan, P. McPhie, Y. Ito, M. Zheng. Single-step total fractionation of single-wall carbon nanotubes by countercurrent chromatography. Analytical Chemistry. 2014, 86 (8): 3980–3984;

(18) Y. Li, N. Wang, M. Zhang*, Y. Ito, H.Y. Zhang, Y.R. Wang, X. Guo, P. Hu*. Development of a method to extract and purify target compounds from medicinal plants in a single step: online hyphenation of expanded bed adsorption chromatography and countercurrent chromatography. Analytical Chemistry. 2014, 86 (7): 3373–3379;

(17) P. Hu, M. Liu, J. Zhao, H.Y. Zhang, Y.R. Wang, M. Zhang*. Integrated expanded bed ion exchange chromatography as a tool for direct recovery shikimic acid from Illicium verum. Solvent Extraction and Ion Exchange. 2014, 32 (3): 316-332;

(16) J.N. Mi, M. Zhang*, H.Y. Zhang, Y.R. Wang, S.K. Wu, P. Hu*. Coupling of ultrasound-assisted extraction and expanded bed adsorption for simplified medicinal plant processing and its theoretical model: extraction and enrichment of ginsenosides from Radix Ginseng as a case study. Journal of Separation Science. 2013, 36 (3): 593-601;

(15) P. Hu, H.Y. Zhang, D.Y. Mao, F.H. Ning, R.J. Wang, Y.R. Wang, M. Zhang. Determination of Homovanilic Acid in Human Urine by Weak Anion-Exchange Hypercrosslinked Polymer Resin-Solid Phase Extraction-High Performance Liquid Chromatography-Ultraviolet Detection Method. Chinese Journal of Analytical Chemistry. 2012, 40 (8): 1175–1180;

(14) J.N. Mi, M. Zhang*, G.X. Ren, H.Y. Zhang, Y.R. Wang, P. Hu*. Enriched separation of protopanaxatriol ginsenosides, malonyl ginsenosides and protopanaxadiol ginsenosides from Panax ginseng using macroporous resins. Journal of Food Engineering. 2012, 113 (4): 577-588;

(13) M. Zhang, S. Ignatova, P. Hu, Q.L. Liang, Y.M. Wang, I. Sutherland, F. Wu, G.A. Luo. Cost-efficient and process-efficient separation of geniposide from Gardenia jasminoides Ellis by high-performance counter-current chromatography. Separation and Purification Technology. 2012, 89: 193-198;

(12) H.Y. Zhang, H.H. Yang, M. Zhang, Y.R. Wang, J.R. Wang, L.F. Yau, Z.H. Jiang, P. Hu. Identification of flavonol and triterpene glycosides in Luo-Han-Guo extract using ultra-high performance liquid chromatography/quadrupole time-of-flight mass spectrometry. Journal of Food Composition and Analysis. 2012, 25 (2): 142-148;

(11) M. Zhang, S. Ignatova, P. Hu, Q.L. Liang, Y.M. Wang, G.A. Luo, F. Wu, I. Sutherland. Development of a strategy and process parameters for a green process in counter-current chromatography: Purification of tanshinone IIA and cryptotanshinone from Salvia miltiorrhiza Bunge as a case study. Journal of Chromatography A. 2011, 1218 (36): 6031-6037;

(10) M. Zhang, H.H. Yang, X. Chen, Y.C. Zhou, H.Y. Zhang, Y.R. Wang, P. Hu. In-situ extraction and separation of salvianolic acid B from Salvia miltiorrhiza Bunge by integrated expanded bed adsorption. Separation and Purification Technology. 2011, 80 (3): 677-682;

(9) M. Zhang, H.H. Yang, H.Y. Zhang, Y.R. Wang, P. Hu. Development of a process for separation of mogroside V from Siraitia grosvenorii by macroporous resins. Molecules. 2011, 16 (9): 7288-7301;

(8) Y.J. Cheng, M. Zhang, Q.L. Liang, P. Hu, Y.M. Wang, F. Wu, G.A. Luo. Two-step preparationofginsenoside-Re, Rb1, Rc and Rb2 from the root of Panaxginseng by high-performance counter-current chromatography. Separation and Purification Technology. 2011, 77 (3): 347-354;

(7) M. Zhang, S. Ignatova, Q.L. Liang, F. Wu, I. Sutherland, Y.M. Wang, G.A. Luo. Rapid and high throughput purification of salvianolic acid B from Salvia miltiorrhiza Bunge by high-performance counter-current chromatography. Journal of Chromatography A. 2009, 1216 (18): 3869-3873;

(6) M. Zhang, P. Hu, Q.L. Liang, H.H. Yang, Q.F. Liu, Y.M. Wang, G.A. Luo. Direct process integration of extraction and expanded bed adsorption in the recovery of crocetin derivatives from Fructus Gardenia. Journal of Chromatography B. 2007, 858 (1-2): 220–226;

(5) M. Zhang, J.N. Mi, X.L. Yang, H.Y. Zhang, Y.R. Wang, P. Hu. HPLC fingerprint of water-soluble constituents of Illicium verum Hook. f. and qualitative analysis of shikimic acid. Shanghai Journal of Traditional Chinese Medicine. 2011, 45 (12): 91-95 (in Chinese);

(4) X. Chen, H.H. Lu, M. Zhang, P. Hu, Y.C. Zhou. Study on the absorption and desorption properties of Salvianolic Acids from Salvia mihiorrhiza Bunge by macroporous resin. Lishizhen Medicine and Materia Medica Research. 2010, 21 (3): 546-548 (in Chinese);

(3) L.Q. Lu, Y.C. Zhou, X. Chen, M. Zhang, J.T. Dai. Dynamic extraction process of salvianolic acids. China Journal of Chinese Materia Medica. 2010, 35 (22): 2976-2979 (in Chinese);

(2) M. Zhang, P. Hu, G.A. Luo, Y.M. Wang. HPLC fingerprint of the water-soluble constituents in Angelica Sinensis. Chinese Traditional Patent Medicine. 2007, 29 (5): 628-630 (in Chinese);

(1) M. Zhang, P. Hu, G.A. Luo, Y.M. Wang. Application of HPLC fingerprint to analysis of rhizome of Panax notoginseng. Chinese Traditional and Herbal Drugs. 2007, 38 (3): 442-445 (in Chinese). 

 

Conference Papers
(4) Y. Li, M. Zhang, H.Y. Zhang, Y.R. Wang, P. Hu*. Two-stage fractionation of polar alkaloids from Rhizoma coptidis by countercurrent chromatography considering the strategy of reactive extraction. The 4th Chinese Conference on Pharmaceutical Analysis. (Oral presentation, 2014, Shanghai, China);
(3) M. Zhang, C.Y Khripin,J.A. Fagan, P. McPhie, Y. Ito, M. Zheng. Single-step complete fractionation of single-wall carbon nanotubes by countercurrent chromatography with an aqueous two-phase solvent system. The 8th International Conference on Countercurrent Chromatography. (CCC2014, London, UK);
(2) P. Hu, M. Liu, M. Zhang*, Y.X. Hua, H.Y. Zhang, Y.R. Wang, G.A. Luo*. From medicinal plant to compound: isolation of shikimic acid from Illicium verum by hyphenated expanded bed adsorption chromatography and counter-current chromatography. The 7th International Conference on Countercurrent Chromatography. (Oral presentation, CCC2012, Hangzhou, China);
(1) M. Zhang, S. Ignatova, P. Hu, Q.L. Liang, Y.M. Wang, G.A. Luo, F.W. Wu, I. Sutherland. Exploiting counter-current chromatography as a green process: purification of tanshinone IIA and cryptotanshinone from Salvia miltiorrhiza Bunge as a case study. The 6th International Conference on Countercurrent Chromatography. (CCC2010, Lyon, France).

 

 
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