梁鑫淼
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電話: 021-64250627
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傳真: 021-64250627
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E-mail: liangxm@dicp.ac.cn
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個(gè)人簡(jiǎn)介
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1987年從杭州大學(xué)免試進(jìn)入大連化物所，攻讀色譜專(zhuān)業(yè)碩士學(xué)位，師從盧佩章院士、張玉奎院士。兩年后，又以?xún)?yōu)異成績(jī)直接攻讀博士學(xué)位，1992年12月畢業(yè)獲博士學(xué)位并留所工作。歷任大連化物所助理研究員、副研究員、研究員，大連化物所副所長(zhǎng)；現(xiàn)任華東理工大學(xué)特聘教授，制藥工程與過(guò)程化學(xué)研究中心主任，廈門(mén)大學(xué)“材料與生命過(guò)程分析科學(xué)”國(guó)家教委開(kāi)放實(shí)驗(yàn)室學(xué)術(shù)委員會(huì)委員、中國(guó)儀器儀表學(xué)會(huì)分析儀器學(xué)會(huì)理事。
自1995年以來(lái)一直從事中藥的化學(xué)物質(zhì)基礎(chǔ)研究，承擔(dān)并完成了國(guó)家973項(xiàng)目“方劑關(guān)鍵科學(xué)問(wèn)題的基礎(chǔ)研究”中“方劑化學(xué)物質(zhì)基礎(chǔ)的研究”課題、中國(guó)科學(xué)院知識(shí)創(chuàng)新工程領(lǐng)域前沿項(xiàng)目“中藥黃芪對(duì)白血病的基因調(diào)控研究及治療藥物的開(kāi)發(fā)”。參加并完成國(guó)家自然科學(xué)基金重點(diǎn)項(xiàng)目“中藥藥效組分的指紋圖譜分析的方法研究”；作為首席科學(xué)家承擔(dān)“中國(guó)科學(xué)院知識(shí)創(chuàng)新工程”重大項(xiàng)目“基于現(xiàn)代理論和技術(shù)的復(fù)方中藥系統(tǒng)研究”。近年來(lái)，在國(guó)內(nèi)外專(zhuān)業(yè)雜志上已發(fā)表研究報(bào)告239篇，其中Angew Chem Int Ed, J Am Chem Soc, Anal Chem, Chem Commun, J Org Chem, Environ Sci Technol, J Chromatogr等SCI論文118篇，已培養(yǎng)博士33名、博士后5名、碩士9名，指導(dǎo)博士生27名、博士后3名、碩士生7名。
研究方向
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學(xué)科涉及制藥工程、藥物化學(xué)、有機(jī)化學(xué)和分析化學(xué)等，主要研究方向?yàn)椋?/p>
1.中藥系統(tǒng)分離純化與化學(xué)表征技術(shù)研究。
2.新型分離材料和分離技術(shù)研究與開(kāi)發(fā)。
3.有機(jī)合成方法學(xué)及其在藥物合成中的應(yīng)用。
4.制藥過(guò)程化學(xué)的研究與開(kāi)發(fā)。
獲獎(jiǎng)成果
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2001.12 遼寧省自然科學(xué)一等獎(jiǎng)
1993.10 第七屆中國(guó)圖書(shū)獎(jiǎng)
2000.4 全國(guó)先進(jìn)工作者稱(chēng)號(hào)
1999.10 遼寧省科技功勛獎(jiǎng)
1998.5 遼寧青年五四獎(jiǎng)?wù)?br /> 1997.4 全國(guó)五一勞動(dòng)獎(jiǎng)?wù)?br /> 1997.3 首屆“中國(guó)科學(xué)院杰出青年”稱(chēng)號(hào)
1997.2 “艱苦奮斗的創(chuàng)業(yè)者”稱(chēng)號(hào)
1997.3 中華人民共和國(guó)國(guó)務(wù)院政府特殊津貼
1995.9 中國(guó)科學(xué)院青年科學(xué)家獎(jiǎng)二等獎(jiǎng)
代表性論著
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代表性論著：(2005年以后)：
1. Zhang, Z. P.; Zheng, Y. J.; Chen, J. P.; Zhang, Q.; Ni, Y. W.; Liang, X. M., Facile Synthesis of Monodisperse Magnesium Oxide Microspheres via Seed-Induced Precipitation and Their Applications in High-Performance Liquid Chromatography. Advanced Functional Materials 2007, in press.
2. Guo, Z. M.; Lei, A. W.; Zhang, Y. P.; Xu, Q.; Xue, X. Y.; Zhang, F. F.; Liang, X. M., “Click Saccharides”: Novel Separation Materials for Hydrophilic Interaction Liquid Chromatography. Chemical Communications 2007, in press.
3. Zhang, Z. P.; Zheng, Y. J.; Zhang, J. X.; Zhang, Q.; Chen, J. P.; Liu, Z. M.; Liang, X. M., Synthesis and shape evolution of monodisperse basic magnesium carbonate microspheres. Crystal Growth & Design 2007, 7, (2), 337-342.
4. Zhou, D. Y.; Xu, Q.; Xue, X. Y.; Zhang, F. F.; Liang, X. M., Identification of O-diglycosyl flavanones in Fructus aurantii by liquid chromatography with electrospray ionization and collision-induced dissociation mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis 2006, 42, (4), 441-448.
5. Zhao, H. X.; Xue, X. Y.; Xu, Q.; Zhang, F. F.; Liang, X. M., Gas chromatographic peak identification for polybrominated diphenyl ethers under different temperature programs. Journal of Chromatography A 2006, 1107, (1-2), 248-256.
6. Zhang, Z. P.; Zheng, Y. J.; Ni, Y. W.; Liu, Z. M.; Chen, J. P.; Liang, X. M., Temperature- and pH-dependent morphology and FT-IR analysis of magnesium carbonate hydrates. Journal of Physical Chemistry B 2006, 110, (26), 12969-12973.
7. Zhang, Z. P.; Zhang, S. G.; Chen, J. P.; Liu, Z. M.; Liang, X. M., Characterization of the surface properties of Mg/Al oxides by the solvation parameter model. Journal of Chromatography A 2006, 1115, (1-2), 58-63.
8. Zhang, X. L.; Martens, D.; Kramer, P. M.; Kettrup, A. A.; Liang, X. M., Development and application of a sol-gel immunosorbent-based method for the determination of isoproturon in surface water. Journal of Chromatography A 2006, 1102, (1-2), 84-90.
9. Zhang, X. L.; Martens, D.; Kramer, P. M.; Kettrup, A. A.; Liang, X. M., On-line immunoaffinity column-liquid chromatography-tandem mass spectrometry method for trace analysis of diuron in wastewater treatment plant effluent sample. Journal of Chromatography A 2006, 1133, (1-2), 112-118.
10. Zhang, G. F.; Liu, R. H.; Xu, Q.; Ma, L. X.; Liang, X. M., Sodium nitrite-catalyzed oxybromination of aromatic compounds and aryl ketones with a combination of hydrobromic acid and molecular oxygen under mild conditions. Advanced Synthesis & Catalysis 2006, 348, (7-8), 862-866.
11. Zeng, Q. H.; Hu, X. P.; Duan, Z. C.; Liang, X. M.; Zheng, Z., Unsymmetrical ferrocenylethylamine-derived monophosphoramidites: Highly efficient chiral ligands for Rh-catalyzed enantioselective hydrogenation of enamides and alpha-dehydroamino acid derivatives. Journal of Organic Chemistry 2006, 71, (1), 393-396.
12. Zeng, G. F.; Xiao, H. B.; Liu, J. X.; Liang, X. M., Identification of phenolic constituents in Radix Salvia miltiorrhizae by liquid chromatography/electrospray ionization mass spectrometry. Rapid Communications in Mass Spectrometry 2006, 20, (3), 499-506.
13. Wang, N. W.; Liu, R. H.; Xu, Q.; Liang, X. M., N-hydroxysuccinimide-promoted oxidation of primary alcohols and aldehydes to form active esters with hypervalent(III) iodine. Chemistry Letters 2006, 35, (6), 566-567.
14. Ma, X.; Xiao, H. B.; Liang, X. M., Identification of ginsenosides in Panax quinquefolium by LC-MS. Chromatographia 2006, 64, (1-2), 31-36.
15. Guo, Z. M.; Lei, A. W.; Liang, X. M.; Xu, Q., Click chemistry: a new facile and efficient strategy for preparation of functionalized HPLC packings. Chemical Communications 2006, (43), 4512-4514.
16. Zhao, H. X.; Zhang, Q.; Xue, X. Y.; Liang, X. M.; Kettrup, A., Predicting gas chromatographic retention times of 209 polybrominated diphenyls (PBBs) for different temperature programs. Analytical and Bioanalytical Chemistry 2005, 382, (5), 1304-1310.
17. Zhang, Y.; Xu, Q.; Zhang, X. Z.; Chen, J. P.; Liang, X. M.; Kettrup, A., High-performance liquid chromatography-tandem mass spectrometry for identification of isoflavones and description of the biotransformation of kudzu root. Analytical and Bioanalytical Chemistry 2005, 383, (5), 787-796.
18. Zhang, Y.; Chen, J. P.; Zhang, C. Z.; Wu, W. Z.; Liang, X. M., Analysis of the estrogenic components in kudzu root by bioassay and high performance liquid chromatography. Journal of Steroid Biochemistry and Molecular Biology 2005, 94, (4), 375-381.
19. Zhang, C. Z.; Zhang, Y. F.; Chen, J. P.; Liang, X. M., Purification and characterization of baicalin-beta-D-glucuronidase hydrolyzing baicalin to baicalein from fresh roots of Scutellaria viscidula Bge. Process Biochemistry 2005, 40, (5), 1911-1915.
20. Zeng, Q. H.; Hu, X. P.; Duan, Z. C.; Liang, X. M.; Zheng, Z., New unsymmetrical hybrid ferrocenylphosphine-phosphoramidite ligands derived from H-8-BINOL for highly efficient Rh-catalyzed enantioselective hydrogenation. Tetrahedron-Asymmetry 2005, 16, (6), 1233-1238.
21. Yu, W. Y.; Zhang, H.; Huang, W. D.; Chen, J. P.; Liang, X. M., Confirmation and identification of the impurities in metolachlor using gas chromatography interfaced with orthogonal acceleration time-of-flight mass spectrometry (GC-oaTOFMS). Talanta 2005, 65, (1), 172-178.
22. Wang, S. S.; Zhao, W. H.; Han, X. W.; Liang, X. M., Two new iridoid glycosides from the Tibetan folk medicine Swertia franchetiana. Chemical & Pharmaceutical Bulletin 2005, 53, (6), 674-676.
23. Wang, N. W.; Liu, R. H.; Chen, J. P.; Liang, X. M., NaNO2-activated, iron-TEMPO catalyst system for aerobic alcohol oxidation under mild conditions. Chemical Communications 2005, (42), 5322-5324.
24. Wang, L. X.; Zhang, L. F.; Wang, S. S.; Xiao, H. B.; Liang, X. M., Discriminating the xanthones in an extract of Swertia franchetiana by retention parameters. Phytochemical Analysis 2005, 16, (1), 34-38.
25. Wang, J. C.; Guo, R. B.; Chen, J. P.; Zhang, Q.; Liang, X. M., Phenylurea herbicides-selective polymer prepared by molecular imprinting using N-(4-isopropylphenyl)-N’-butyleneurea as dummy template. Analytica Chimica Acta 2005, 540, (2), 307-315.
26. Ma, X. Q.; Liang, X. M.; Xu, Q.; Zhang, X. Z.; Xiao, H. B., Identification of ginsenosides in roots of Panax ginseng by HPLC-APCI/MS. Phytochemical Analysis 2005, 16, (3), 181-187.
27. Liu, R. H.; Dong, C. Y.; Liang, X. M.; Wang, X. J.; Hu, X. Q., Highly efficient catalytic aerobic oxidations of benzylic alcohols in water. Journal of Organic Chemistry 2005, 70, (2), 729-731.
28. Liang, X. M.; Fu, D. M.; Liu, R. H.; Zhang, Q.; Zhang, T. Y.; Hu, X. Q., Highly efficient NaNO2 - Catalyzed destruction of trichlorophenol using molecular oxygen. Angewandte Chemie-International Edition 2005, 44, (34), 5520-5523.
29. Fu, S. P.; Zhang, F.; Zhang, X. Z.; Xu, Q.; Xiao, H. B.; Liang, X. M., Physicochemical characterization of the Strychnos alkaloids by capillary zone electrophoresis. Analytical Sciences 2005, 21, (11), 1303-1308.
