劉仁華 教授 博士生導(dǎo)師
電話: 86-21-64250627 ；傳真: 86-21-64250627
E-mail: liurh@ecust.edu.cn
地址：上海梅隴路130號實驗18樓919
個人簡介
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60年代生于廣西桂北山區(qū)融安縣，幼時擅長捕魚抓鳥，放牧經(jīng)驗豐富。1993年獲中國科學(xué)院蘭州化學(xué)物理研究所碩士學(xué)位；2000年至2006中國科學(xué)院大連化學(xué)物理研究所，從事有機合成方法學(xué)、綠色氧化及環(huán)境污染物的氧化降解方面的研究。2007年1月受聘于華東理工大學(xué)藥學(xué)院，從事有機、藥物合成方法學(xué)以及環(huán)境污染物降解方向的研究。2011年被廣西壯族自治區(qū)黨委人才工作小組聘任為廣西首批特聘專家。目前以第一作者或通訊作者在J. Am. Chem. Soc.; Angew. Chem. Int. Ed.; Chem. Sci ; Chem. Eur. J.;Chem. Comm.;Org lett, 以及 J. Org. Chem.;Environ. Sci. Technol；Adv. Synth. & Catal.等雜志發(fā)表論文數(shù)十篇，應(yīng)邀在Chem. Soc. Rev.撰寫評論文章1篇。應(yīng)邀參與全國本科醫(yī)藥規(guī)范教材《藥物合成反應(yīng)》以及全國高等醫(yī)藥十二五規(guī)范教材《藥物合成反應(yīng)》的編寫。獲專利20項。迄今，文章被他人引用2000余次，單篇最高被SCI引用300次，其中J. Am. Chem. Soc.; Angew. Chem. Int. Ed.; J. Org. Chem.三篇文章曾被Angew. Chem. Int. Ed.在Highlights專欄重點評述。作為項目負(fù)責(zé)人承擔(dān)國家863課題及國家自然科學(xué)基金項目3項，參與中國科學(xué)院知識創(chuàng)新工程重要方向項目一項。
研究方向
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1.有機合成方法學(xué)：新型有機合成反應(yīng)的設(shè)計和發(fā)展；新催化劑的設(shè)計、合成及其在有機合成中的應(yīng)用；精細(xì)有機中間體的工藝開發(fā)。
2. 綠色氧化：催化有氧氧化方法學(xué)的研究。主要致力于發(fā)展氧分子的有效活化及控制的新方法，著重解決催化氧化反應(yīng)中催化劑的催化活性,反應(yīng)選擇性及催化劑的穩(wěn)定性等關(guān)鍵科學(xué)問題。
3. 環(huán)境污染物的氧化降解：基于氧氣活化的新方法及其他創(chuàng)新技術(shù)，設(shè)計并發(fā)展高效、綠色、便宜的氧化降解方法消減環(huán)境難降解污染物。
代表性論著
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1) Li JM, Zhang J, Li MF, Zhang CY, Yuan YK, Liu, RH*, Naphtho[2,3-b]furan-4,9-dione synthesis via palladium-catalyzed reverse hydrogenolysis, Chem. Commun., 55, 2348--2351, 2019
2) Yang D, Ji X, Zhang J, Zhang C, Li M, Li J, Liu, RH*, Pd/C-catalyzed dehydrogenation of 2- Q1 cinnamoylbenzoic acids to 3-benzylidene-3Hisochroman-1,4-diones, Chem. Commun., 54, 7774--7777, 2018.
3) Jiang Q, Qi X, Zhang C, Ji X, Li J, Liu, RH*, Oxidant- and hydrogen acceptor-free palladium catalyzed dehydrogenative cyclization of acylhydrazones to substituted oxadiazoles,Org. Chem. Front., 5, 386-390, 2018.
4) Zhao X., Zhou J., Lin S., Jin X., Liu R.*, C-H Functionalization via Remote Hydride Elimination: Palladium Catalyzed Dehydrogenation of ortho-Acyl Phenols to Flavonoids.Org. Lett., 19, 976-979, 2017.(Highlighted by Organic Chemistry Portal: www.organic-chemistry.org/abstracts/lit5/757.shtm)
5) Yang D., Zhu Y., Yang N., Jiang Q., Liu R.*, One-Step Synthesis of Substituted Benzofurans from ortho-Alkenylphenols via Palladium-Catalyzed C-H Functionalization.Adv. Synth. Catal., 358, 1731-1735, 2016.
6) J. Zhang, Q. Jiang, D. Yang, X. Zhao, Y. Dong and R. Liu*, Reaction-Activated Palladium Catalyst for Dehydrogenation of Substituted Cyclohexanones to Phenols and H2 without Oxidants and Hydrogen Acceptors, Chem. Sci., 6, 4674-4680, 2015.
7) Liu, YX; Deng, YM; Zavalij, PY; Liu, RH; Doyle, MP, An efficient route to highly enantioenriched tetrahydroazulenes and beta-tetralones by desymmetrization reactions of delta,delta-diaryldiazoaceto-acetates,Chem. Commun., 51(3), 565-568, 2015.
8) Chai, HH; Guo, RQ; Yin, W; Cheng, LP; Liu, RH; Chu, CH, One-Pot, Three-Component Reaction Using Modified Julia Reagents: A Facile Synthesis of 4,5-Disubstituted 1,2,3-(NH)-Triazoles in a Wet Organic Solvent,ACS Comb. Sci., 17(3), 147-151, 2015.
9) Yin, W; Chai, HH; Liu, RH; Chu, CH; Palasota, JA; Cai, XH, Click N-benzyl iminodiacetic acid: Novel silica-based tridentate zwitterionic stationary phase for hydrophilic interaction liquid chromatography, Talanta, 132, 137-145, 2015
10) Shen, JX; Sun, JK; Qin, SS; Chu, CH; Liu, RH*, 4-Benzamido-TEMPO Catalyzed Oxidation of a Broad Range of Alcohols to the Carbonyl Compounds with NaBrO3 under Mild Conditions,Chin. J. Chem., 32(5), 405-409, 2014.
11) Shen, JX; Yang, DJ; Liu, YX; Qin, SS; Zhang, JW; Sun, JK; Liu, CH; Liu, CY; Zhao, XM; Chu, CH; Liu, RH*, Copper-Catalyzed Aerobic Oxidative Coupling of Aromatic Alcohols and Acetonitrile to beta-Ketonitriles, Org. Lett., 16(2), 350-353. 2014.(Highlighted by Organic Chemistry Portal: www.organic-chemistry.org/abstracts/lit4/327.shtm)
12)Yang, JJ; Yin, W; Liu, RH; Chu, CH, Ti(Oi-Pr)4 Mediated Olefination between Julia Reagent and Aldehydes under Mild Conditions: Facile Synthesis of Vinyl Sulfones, J. Chin. Chem. Soc., 60( 4), 412-417, 2013
13)Jin, XK; Liu, YX; Lu, QQ; Yang, DJ; Sun, JK; Qin, SS; Zhang, JW; Shen, JX; Chu, CH; Liu, RH*, Formation of C=N bonds by the release of H2: a new strategy for synthesis of imines and benzazoles, Org. Biomol. Chem., 11(23), 3776-3780, 2013
14)Yang, JJ; Yin, W; Liu, RH; Chu, CH, Facile Synthesis of 4,5-Disubstituted 2H-1,2,3-Triazoles by Catalyst-free Cycloaddition between Substituted Vinyl Sulfones and Sodium Azide under Ambient Conditions,Chin. J. Chem., 30(12), 2786-2790, 2012
15)Guo, HY; Liu, RH; Yang, JJ; Yang, BC; Liang, XM; Chu, CH, A novel click lysine zwitterionic stationary phase for hydrophil2012ic interaction liquid chromatography,J. Chromatogr. A, 1223, 47-52. 2012
16)Lu QQ, Liao NC, Chua CH, Shen JX, Liu YX, Tao JW, Liang XM, Liu RH*. Dioxygen in combination with hydrazine: A practical system for degradation of a broad spectrum of toxic organics in water. J. Hazard. Mater.; 192(3), 1186-1191. 2011.
17)Chu CH, Liu RH; Application of click chemistry on preparation of separation materials for liquid chromatography; Chem. Soc. Rev., 40, 2177-2188, 2011.
18)Chu CH, Liu RH*; Chloralkanes as chlorinating agents: An efficient approach to acyl chlorides and destruction of chlorinated hydrocarbons; Appl. Catal. B: Environ.; 101, 343–347, 2011.
19)Tao JW, Lu QQ, Chu CH, Liu RH*, Liang XM; A 4-MeO-TEMPO, PEG-NO2 and HCl Catalytic System for Highly Efficient Aerobic Oxidation of Alcohol;Synthesis; 23, 3974-3976, 2010.
20)Yin WL, Chu CH, Lu QQ, Tao JW , Liang XM, Liu RH*; Iron Chloride/4-Acetamido- TEMPO/Sodium Nitrite-Catalyzed Aerobic Oxidation of Primary Alcohols to the Aldehydes; Adv. Synth. Catal.; 352, 113-118, 2010.
21)Zhang H, Chen CY, Liu RH, Xu Q, Zhao WQ; Transition-Metal-Free Highly Efficient Aerobic Oxidation of Sulfides to Sulfoxides under Mild Conditions; Molecules; 15, 83-92, 2010.
22)Fu DM, Peng YR, Liu RH*, Zhang FF, Liang XM; Concurrent destruction strategy: NaNO2-catalyzed, trichlorophenol-coupled degradation of p-nitrophenol using molecular oxygen; Chemoshere; 75, 701-706, 2009.
23)Zhang H, Chen CY, Liu RH, Xu Q, Liu JH; DBDMH/NaNO2 Catalyst: Transition -Metal-Free Approach to Highly Efficient Aerobic Oxidation of Sulfides to Sulfoxides; Synth. Commun.; 38, 4445-4451, 2008.
24)Peng YR, Fu DM, Liu RH*, Zhang FF, Liang XM; NaNO2/FeCl3 catalyzed wet oxidation of the azo dye Acid Orange 7;Chemoshere; 71, 990-997, 2008.
25)XL, Liu RH, Jin Y, Liang XM; TEMPO/HCl/NaNO2 catalyst: A transition- metal-free approach to efficient aerobic oxidation of alcohols to aldehydes and ketones under mild conditions;Chem. Eur. J.; 14, 2679-2685, 2008.
26)Peng YR, Fu DM, Liu RH*, Zhang FF, Xue XY, Xu Q, Liang XM; NaNO2/FeCl3 dioxygen recyclable activator: An efficient approach to active oxygen species for degradation of a broad range of organic dye pollutants in water; Appl. Catal. B Environ.; 79, 163-170, 2008.
27)Wang LZ, Zhang FF, Liu RH*, Zhang TY, Xue XY, Xu Q, Liang XM; FeCl3/NaNO2: An efficient photocatalyst for the degradation of aquatic steroid estrogens under natural light irradiation;Environ. Sci. Technol.; 41, 3747-3751, 2007.
28)Fu DM, Liu RH, Xu Q, Xue XY, Zhang FF, Liang XM; Kinetic study on wet air co-oxidation of phenol at presence of nitrobenzene; Fres. Environ. Bull.; 16, 71-75, 2007.
29)Wang NW, Liu RH, Xu Q, Liang XM; N-hydroxysuccinimide-promoted oxidation of primary alcohols and aldehydes to form active esters with hypervalent(III) iodine; Chem. Lett.; 36, 566-567, 2006.
30)Zhang GF, Liu RH*, Xu Q, Ma LX, Liang XM; Sodium nitrite-catalyzed oxybromination of aromatic compounds and aryl ketones with a combination of hydrobromic acid and molecular oxygen under mild conditions; Adv. Synth. Catal.; 348, 862-866, 2006.
31)Wang NW, Liu RH*, Chen JP, Liang XM; NaNO2-activated, iron-TEMPO catalyst system for aerobic alcohol oxidation under mild conditions; Chem. Commun.; 42, 5322-5324, 2005.
32)Liang XM, Fu DM, Liu RH*, Zhang Q, Zhang TY, Hu XQ; Highly efficient NaNO2 - Catalyzed destruction of trichlorophenol using molecular oxygen; Angew. Chem. Int. Ed.; 44, 5520-5523, 2005.
33)Liu RH, Dong CY, Liang XM, Wang XJ, Hu XQ; Highly efficient catalytic aerobic oxidations of benzylic alcohols in water;J. Org. Chem.; 70, 729-731, 2005.
34)Liu RH, Liang XM, Dong CY, Hu XQ; Transition-metal-free: A highly efficient catalytic aerobic alcohol oxidation process; J. Am. Chem. Soc.; 126, 4112-4113, 2004.
35)Ye JX, Wang YC, Liu RH, Zhang GF, Zhang Q, Chen JP, Liang XM; A highly enantioselective phase-transfer catalyzed epoxidation of enones with a mild oxidant, trichloroisocyanuric acid;Chem. Commun.; 2714-2715, 2003.
