徐玉芳 教授
Tel: 021-64251399; Fax: 021-64252603
E-mail: yfxu@ecust.edu.cn
個(gè)人簡介
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徐玉芳，博士，教授，博士生導(dǎo)師。上海市優(yōu)秀學(xué)科帶頭人。1994年博士畢業(yè)于華東理工大學(xué)精細(xì)化工專業(yè)；1999-2001日本東京醫(yī)科齒科大學(xué)博士后；2004.9至今華東理工大學(xué)教授。2006年日本京都大學(xué)日本學(xué)術(shù)振興會(huì)(JSPS)訪問學(xué)者。近年來主要從事化學(xué)生物技術(shù)方面的研究，主要包括熒光傳感技術(shù)及細(xì)胞激活與調(diào)控技術(shù)。主持完成了國家自然科學(xué)基金、國家重大新藥創(chuàng)制項(xiàng)目、國家科技支撐計(jì)劃、上海市光科技重點(diǎn)項(xiàng)目、上海市科委基礎(chǔ)研究重點(diǎn)項(xiàng)目，共同主持完成了國家973子課題。目前承擔(dān)著上海市優(yōu)秀學(xué)科帶頭人計(jì)劃、共同承擔(dān)著863專項(xiàng)。迄今為止，申請(qǐng)中國發(fā)明專利41項(xiàng)，授權(quán)13項(xiàng)，國際PCT 4項(xiàng)，獲美國、歐盟授權(quán)。已在J. Am. Chem. Soc.、Angew. Chem. Int.、Chem. Comm.、J. Med. Chem.、Org. Lett.等國際SCI期刊發(fā)表論文100余篇，SCI 他引1100余次，單篇最高他引100余次(J. Am. Chem. Soc.,2008)。《Journal of Pharmaceutics 》國際編委、《Chinese Chemical Letters》、《現(xiàn)代藥物與臨床》編委。
研究方向
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A:熒光傳感技術(shù)
A-1 純水體系高選擇性高靈敏重金屬離子熒光探針及其活體細(xì)胞應(yīng)用：針對(duì)環(huán)境和生物組織中的重要重金屬及過渡金屬離子,設(shè)計(jì)、創(chuàng)制純水體系、高選擇性、高靈敏金屬離子熒光探針，并實(shí)現(xiàn)活體細(xì)胞應(yīng)用。
A-2 生物體內(nèi)重要靶酶診療熒光探針：針對(duì)疾病生物標(biāo)志物，設(shè)計(jì)創(chuàng)制一系列特異性響應(yīng)熒光探針，對(duì)疾病進(jìn)行早期診斷與治療。
B:細(xì)胞激活與調(diào)控技術(shù)
B-1 新型植物激活劑：設(shè)計(jì)創(chuàng)制各類植物抗病激活劑及能明顯增加植物次生代謝物的高效細(xì)胞激活劑。
B-2 新作用機(jī)制抗腫瘤藥物先導(dǎo)：基于不同母體結(jié)構(gòu)，設(shè)計(jì)創(chuàng)制新作用機(jī)制抗腫瘤藥物先導(dǎo)。
B-3 乏氧特異性前藥: 利用乏氧特異性響應(yīng)基團(tuán)，設(shè)計(jì)創(chuàng)制乏氧選擇性抗腫瘤試劑。
獲獎(jiǎng)成果
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2008年國家科技進(jìn)步二等獎(jiǎng)（九）；
2008年上海市自然科學(xué)一等獎(jiǎng)（四）;
2007年上海市優(yōu)秀學(xué)科帶頭人。
代表性論著
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1) Qingshan Du, Weiping Zhu, Zhenjiang Zhao*, Xuhong Qian, Yufang Xu* Novel Benzo-1, 2,3-thiadiazole-7-carboxylate derivatives as plant activators and the development of their agriculturalapplications, Journal of Agricultural Food Chemistry, 2012, 60, 346-353
2) Shenyi Zhang, Chunmei Yang, Weiping Zhu, Bubing Zeng, Youjun Yang, Yufang Xu*, Xuhong Qian*,Highly selective, naked-eye and fluorescent “off-on” probe for detection of histidine/histidine-rich protein and its application in living cell imaging, Org. Biomol. Chem.,2012,10,1653-1658
3) Tanyu Cheng, Tao Wang, Weiping Zhu, Xinlei Chen, Youjun Yang, Yufang Xu*, Xuhong Qian*,Red-emission fluorescent probe sensing cadmium andpyrophosphate selectively in aqueous solution,Org. Lett., 2011, 13, 3656-3659.
4) Shenyi Zhang, Chunmei Yang, Weiqiang Lu, Jin Huang, Weiping Zhu, Honglin Li, Yufang Xu*, Xuhong Qian*, A Highly Selective Space-folded Photo-induced Electron Transfer Fluorescent Probe for Carbonic Anhydrase Isozymes IX and Its Applications for Biological Imaging, Chem. Commun., 2011, 47,8301-8303
5) Kishore Baathulaa, Yufang Xu, Xuhong Qian, Short and Scalable Synthesis of an Anhydride Precursor of the Environment-sensitive Fluorophore 6-DMN, Nature Protocols, 2011, 6,1990-1997.
6) Weiqiang Lu, Xiaofeng Liu, Xianwen Cao, Mengzhu Xue, Kangdong Liu, Zhenjiang Zhao, Xu Shen,Hualiang Jiang, Yufang Xu, Jin Huang*, and Honglin Li*，SHAFTS: A Hybrid Approach for 3D Molecular Similarity Calculation. 2. Prospective Case Study in the Discovery of Diverse p90 Ribosomal S6 Protein Kinase 2 Inhibitors to Suppress Cell Migration, J. Med. Chem. 2011, 54 (10), 3564–3574
7) Zhuo Chen, Xin Wang, Weiping Zhu, Xianwen Cao, Linjiang Tong, Honglin Li, Hua Xie,* Yufang Xu,* Shaoying Tan, Dong Kuan, Jian Ding, Xuhong Qian,* Acenaphtho[1,2-b]pyrrole-BasedSelective Fibroblast Growth Factor Receptors 1 (FGFR1) Inhibitors : Design, Synthesis and Biological Activity, J. Med. Chem. 2011, 54 (11), 3732–3745
8) Chusen Huang, Qin Yin, Weiping Zhu*, Yi Yang*, Xin Wang, Xuhong Qian, Yufang Xu*, Highly Selective Fluorescent Probe for Vicinal Dithiol-Containing Proteins and In-Situ Imaging in Living Cells, Angew. Chem. Int., 2011, 50(33), 7551-6.
9) Hong Yin, Weiping Zhu, Yufang Xu*, Min Dai, Xuhong Qian*, Yuanli Li, Jianwen Liu, Novel aliphatic N-oxide of naphthalimides as fluorescent markers for hypoxic cells in solid tumor, European Journal of Medicinal Chemistry, 2011, 46 ,3030-3037
10) Tanyu Cheng, Tao Wang, Weiping Zhu, Yangyang Yang, Bubing Zeng, Yufang Xu* and Xuhong Qian*, Modulating the selectivity of Near Infrared Fluorescent Probes Toward Various Metal Ions by Judicious Choice of Aqueous Buffer Solutions, Chem. Commun., 2011, 47, 3915-3917.
11) Lei Cui, Ye Zhong, Weiping Zhu, Yufang Xu*, Qingshan Du, Xin Wang, Xuhong Qian*, and Yi Xiao, A Novel Prodrug-Derived Ratiometric Fluorescent Probe for Hypoxia: High Selectivity of Nitroreductase and Imaging in Tumor Cell, Org. Lett., 2011, 13, 928-931.
12) Yangyang Yang, Tanyu Cheng, Weiping Zhu, Yufang Xu,* Xuhong Qian*, Highly Selective and Sensitive Near-infrared Fluorescent Sensors for Cadmium in Aqueous Solution, Org. Lett., 2011, 13, 264-267.
13) Lei Cui, Ye Zhong, Weiping Zhu, Yufang Xu*, Xuhong Qian*, Selective and Sensitive Detection and Quantification of Arylamine N-Acetyltransferase 2 by a Ratiometric Fluorescence Probe, Chem. Commun., 2010, 46, 7121 - 7123 (Highlights in Chemical Biology, Predicting drug response, Harriet Brewerton,27 August 2010）
14) Zhuo Chen, Xin Liang, Huanying Zhang, Hua Xie, Jianwen Liu, Yufang Xu*, Weiping Zhu, Yi Wang, Xin Wang, Shaoying Tan, Dong Kuang, Xuhong Qian,*A New Class of Naphthalimide-based Antitumor Agents that Inhibit Topoisomerase II (Topo II) and Induce Lysosomal Membrane Permeabilization (LMP) and Apoptosis，J. Med. Chem. 2010, 53, 2589–2600
15) Tanyu Cheng, Yufang Xu,* Shenyi Zhang, Weiping Zhu, Xuhong Qian,* Liping Duan A highly sensitive and selective OFF-ON fluorescent sensor for cadmium in aqueous solution and living cell, J. Am. Chem. Soc., 2008, 130 (48), 16160–16161
