研究方向
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主要研究領(lǐng)域：制藥工程與技術(shù)；合成藥物化學
主要研究方向：
1 重點藥物品種的合成工藝研究
2 藥物綠色高效合成方法研究
3 基于臨床和綠色高效合成方法的藥物（抑郁癥、感染性疾病和癌癥等疾病治療藥物）設(shè)計與合成
方法學研究標新立異；產(chǎn)業(yè)化項目簡易實用；藥物發(fā)現(xiàn)著眼于臨床，趨于定向。熱誠歡迎國內(nèi)外企業(yè)和科研院所合作研究；熱誠歡迎具有良好有機合成基礎(chǔ)、有志于從事新藥研究和藥物合成工藝研究的有志之士來本實驗室攻讀碩士、博士學位，或進行博士后研究！
獲獎成果
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國家新藥證書，國家授權(quán)專利，上海市工業(yè)園區(qū)理工教師創(chuàng)新獎，上海市教學成果一等獎（5），華東理工大學教學成果一等獎，華東理工大學育英獎一等獎等。
代表性論著
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(1) Zhang, Huiwen; Ma, Chunmei; Zheng, Ziwei; Sun, Rengwei; Yu, Xinhong*; Zhao, Jianhong*. Synthesis of 2-arylbenzofuran-3-carbaldehydes via an organocatalytic [3+2] annulation/oxidative aromatization reaction. Chem. Commun.，2018, 54, 4935-4938.
(2) Tang, Mi; Sun, Rengwei; Li, Hao; Yu, Xinhong*; Wang, Wei*. An Unconventional Redox Cross Claisen Condensation–Aromatization of 4-Hydroxyprolines with Ketones. J. Org. Chem.，2017, 82, 8419-8425.
(3) Sun, Rengwei; Song, Wei; Ma, Chunmei; Zhang, Huiwen; Yu, Xinhong*. Titanium(IV) Chloride-Mediated Stereoselective α-Alkylidenation to Efficiently Assemble Multisubstituted 1,3-Dienes. Adv. Synth. Catal.，2016, 358, 3977-3982.
(4) Song, Guangjun; Zheng, Ziwei; Wang, Yanhui; Yu, Xinhong*. Pd-Catalyzed Site-Selective p-Hydroxyphenyloxylation of Benzylic α-C(sp3)–H Bonds with 1,4-Benzoquinone. Org. Lett.，2016, 18, 6002-6005.
(5) Tang, Mi; Tong, Lingfeng; Ju, Lei; Zhai, Wanwan; Hu, Yang; Yu, Xinhong*. Benzoic Acid Catalyzed Annulations of α-Amino Acids and Aromatic Aldehydes Containing an ortho-Michael Acceptor: Access to 2,5-Dihydro-1H-benzo[c]azepines and 10,11-Dihydro-5H-benzo[e]pyrrolo[1,2-a]azepines. Org. Lett.，2015, 17, 5180-5183.
(6) Hu, Yang; Ma, Yueyue; Sun, Rengwei; Yu, Xinhong*; Xie, Hexin*; Wang, Wei*. Amine-Catalyzed Highly Regioselective and Stereoselective C(sp2)-C(sp2) Cross-Coupling of Naphthols withtrans-α,β-Unsaturated Aldehydes. Chemistry - An Asian Journal，2015, 10, 1859-1863.
(7) Hu, Yang; Ju, Lei; Lu, Lin; Ma, Hongmei; Yu, Xinhong*. Stereoselective α-indolylation of enals via an organocatalytic formal cross-coupling with indoles. Org. Biomol. Chem.，2015, 13, 8869-8874.
(8) Xu Zian,Zhai WanWan, Feng CongPeng, Liu Hongwei*, Zhao JianHong * and Yu Xinhong*.Water-mediated three-component Wittig-SNAr Reactions. Synlett, 2015, 26, 820-826.
(9) Xu Zian，Ge Jingying，Wang Tianchi, Luo Ting, Liu Hongwei* and Yu Xinhong*. Highly Stereoselective Synthesis of 2-Aminobenzylidene Derivatives by A Convergent 3-Component Approach. Synlett, 2014, 25, 2913-2917.
(10) Zou Zhiqin, Deng Zejun, Yu Xinhong*, Zhang Manman, Zhao Sihan, Luo Ting, Yin Xin, Xu Hui and Wang Wei*. A new facile approach to N-alkylpyrroles from direct redox reaction of 4-hydroxy-L-proline with aldehydes. Science China–Chem, 2012, 55(1), 43-49.
(11) Xie Hexin, Zhang Shilei*, Li Hao, Zhang Xinshuai, Zhao Sihan, Xu Zian, Song Xixi, Yu Xinhong*, Wang Wei*. Total synthesis of polyene natural product dihydroxerulin by mild organocatalyzed dehydrogenation of alcohols. Chem. Eur. J, 2012, 18(8),2230-2234.
(12) Zhang Xishuai, Song Xixi, Li Hao, Zhang Shilei, ChenXiaobei, Yu Xinhong*and Wang Wei*. Efficient synthesis of poly-substituted quinolines and chiral 1,4-dihydroquinolines by an organocatalytic cascade approach. An unanticipated effect of “N” protecting groups on formed products . Angew. Chem. Int. Ed., 2012, 51,7282-7286.
(13) Wang Jian, Zhang Manman, Zhang Shieli, Xu ZiAn, Li Hao, Yu Xinhong*, Wang Wei*. Chiral pyrrolidine sulfonamide catalyzed enantioselective Michael addition of cyclohexanones to maleimides. Synlett, 2011, (4): 473-476.
(14) Zhang Shilei, Xie Hexin, Song Aiguo, Wu Deyan, Zhu Jin, Zhao Sihan, Li Jian*, Yu Xinhong* and Wang Wei*. Efficient preparation of trans-α,β-unsaturated aldehydes from saturated aldehydes by oxidative enamine catalysis. Science China–Chem, 2011, 54(12), 1932-1936.
(15) Yu Xinhong, Wang Wei *. Organocatalysis: asymmetric cascade reactions catalysed by chiral secondary amines. Org. Biomol. Chem., 2008, 6(12), 2037-2046. 該論文作為封面介紹.
(16) Yu Xinhong, Wang Wei *. Hydrogen-bond-mediated asymmetric catalysis. Chem. Asian J.,2008, 3(3): 516-532.
(17) Zu Liansuo, Xie Hexin, Li Hao, Wang Jian, Yu Xinhong*, Wang Wei*. Chiral amine catalyzed enantioselective cascade aza-ene-type cyclization reactions. Chem. Eur. J., 2008, 14(21),6333-6335.
(18) Xu Hui, Yu Xinhong*, Sun Leying, Liu Jing, Fan Wen, Shen Yongjia*,Wang Wei *. Microwave-assisted three-component Knoevenagel-nucleophilic aromatic substitution reactions. Tetrahedron Lett., 2008, 49(32):4687-4689.
(19) Zu Liansuo, Li Hao, Wang Jian, Yu Xinhong*, Wang Wei*. Highly enantioselective aldehyde-nitroolefin Michael addition reactions catalyzed by recyclable fluorous (S) diphenylpyrrolinol silyl ether. Tetrahedron Lett., 2006, 47(29): 5131-5134.
(20) Yu Xinhong. Rational drug synthesis based on green efficient synthetic mothodologies. The 6th International Symposium for Chinese Medicinal Chemists. July 28-August 2, 2008, OP-11/93.
(21) Wang Jian, Li Hao, Yu Xinhong, Zu Liansuo, Wang Wei*.Chiral binaphthyl-derived amine-thiourea organocatalyst-promoted asymmetric Morita-Baylis-Hillman reaction.Org. Lett., 2005, 7(19): 4293-4296. 該工作是Org. Lett. 2005, 2006 和2007 年的“熱點文章”和“引用率最高”的論文之一.
發(fā)明專利：
1. 虞心紅，鄒志芹，張曼曼，鄧澤軍，羅婷，徐子安，徐輝。吡咯衍生物的制備方法[P]. 中國發(fā)明專利：ZL 2011 1 0040281.X，授權(quán)公告日：2012-11-14.
2. 虞心紅，殷昕，劉建文，張曼曼，劉連軍，李義全具有抗腫瘤作用的二元羧酸雙（異羥肟酸）酯及制備方法. 中國發(fā)明專利：ZL 2011 1 0357871.5，授權(quán)公告日：2015-2-25..
3. 虞心紅，劉連軍，張曼曼，劉建文，羅婷，程卓安。具有抗腫瘤作用的二元羧酸衍生物及制備方法. 中國發(fā)明專利：ZL 2011 1 0305131.7，授權(quán)公告日：2014-6-11.
4. 虞心紅，張曼曼，劉連軍，劉建文，程卓安。異羥肟酸的二元羧酸單酯衍生物的抗腫瘤作用和制備方法. 中國發(fā)明專利：ZL 2011 1 0054331.X，授權(quán)公告日：2014-7-16.
5. 虞心紅，張曼曼，徐輝，徐子安，劉連軍，金惠。具有抗腫瘤作用的N-苯基-N’-(末端羧酸取代酰氧基)辛二酰胺類化合物及其藥用鹽[P]. 中國發(fā)明專利：ZL 2011 1 0054331.X，授權(quán)公告日：2014-7-16.
6. 虞心紅，張衛(wèi)東，談遂初，呂和平，劉金平，毛慶華，趙恒，沈永嘉，傅收，王偉，黃文超。一種制備N-芳酰基-L-谷氨酸的方法[P]. 中國發(fā)明專利：ZL 03 1 28982.7，授權(quán)公告日2006-03-29.
7. 虞心紅，張延鋒，彭藝閣，鄭蓉，侯志安，林童，徐書海，沈永嘉，田禾。生物前藥咪唑[1,2-a]并吡啶鹵化物及其制備方法[P]. 中國發(fā)明專利ZL 01 1 12825.9，授權(quán)公告日2005-03-23.
