冀亞飛  教授 博士研究生導師 
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微信號留言: ecust-jyf 

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通信地址：200237  上海市梅隴路130號363信箱

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E-mail:jyf@ecust.edu.cn
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個人簡介

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1989年9月—1992年6月          華東化工學院精細化工系學習，獲工學碩士學位。

1992年8月—1996年10月        安徽省藥物研究所工作，任助理研究員。

1996年11月—2001年11月      中國礦業(yè)大學化工學院工作、學習，任講師、副教授，獲工學博士學位。

2001年12月—2003年11月      中國醫(yī)學科學院中國協(xié)和醫(yī)科大學藥物研究所從事博士后科研工作。

2003年12月—2007年8月        華東理工大學藥學院制藥工程系從事制藥工程和綠色化學領域的科研、教學工作，任副教授。

2007年9月                               評聘為教授。

2009年3月—2010年3月          赴美國University of New Mexico做訪問學者

2011年4月—今                       制藥工程系教授、博士研究生導師

       多年來國內外發(fā)表論文170余篇，獲得中國發(fā)明專利授權10項，獲省部級科技進步獎3項，上海市教學一等獎1項，校級獎項6項。擔任制藥工程系制藥工藝學責任教授，受邀作為精細化工，應用化學，Research on Chemical Intermediates,Synthetic Communications, Catalysis Letters, Fuel Processing Technology等國內外刊物的審稿人；受邀作為國家自然科學基金委評議人。有多個藥物合成工藝在企業(yè)得到應用，具有知識產(chǎn)權的新一代甲氧芐啶、甲乙基香蘭素綠色技術居于領先水平。承擔重大應用課題、國家自然科學基金、博士點基金等二十余項科研課題。熱情歡迎國內外企業(yè)合作開發(fā)化學藥物及精細化工產(chǎn)品合成技術，熱烈歡迎有志青年加盟從事制藥工程與技術專業(yè)方向的碩士、博士學位研讀，以及從事博士后研究。課題組同學多人獲得國家博士、碩士研究生獎學金，及學校、學院研究生獎學金。

研究方向
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1 綠色化學 

2 雜環(huán)類藥分子的設計與合成

4 有機合成中的區(qū)域與立體選擇性控制研究 

獲獎成果
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2021年12月獲2020-2021學年度：華東理工大學優(yōu)秀研究生指導教師

2021年6月獲2020年華東理工大學教學成果二等獎：線上線下一體化的《制藥工藝學》課程建設與實踐

2020年12月榮獲2020年度華東理工大學“東岳藥業(yè)研究生獎教金”

2019年12月獲2018年華東理工大學教學成果二等獎：上海市精品課程《制藥工藝學》課程建設與實踐

2017年4月主持“制藥工藝學”核心課程被授予上海市精品課程 

2017年4月獲2016年華東理工大學教學成果一等獎：深化制藥工藝學課程建設，踐行“卓越工程師培養(yǎng)計劃”素質教育

2014年9月獲2013年高等教育上海市教學成果一等獎：強實踐、重創(chuàng)新，培養(yǎng)適應現(xiàn)代制藥工程需求的專業(yè)人才

2014年1月獲華東理工大學2013年度研究生課程優(yōu)秀任課教師一等獎

2011年9月華東理工大學國家技術轉移中心：“優(yōu)秀技術轉移項目” 

2008年9月華東理工大學教育教學成果一等獎：“制藥工程專業(yè)質量保障體系”

2006年12月獲江蘇省科技進步獎三等獎：“煤的高效利用研究”

2006年11月獲中國石油和化學工業(yè)科技進步獎一等獎：“煤的高附加值利用的基礎研究”

2004年11月獲山東省科技進步獎三等獎：“甲氧芐啶的研制與開發(fā)”

對制藥工藝學教學的貢獻

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1 在近二十年教學生涯中，總結教學規(guī)律，以第一作者發(fā)表教育教學論文十余篇

2 作為責任教授主持“制藥工藝學”核心課程教學，該課被授予上海市精品課程

3 倡導基于最優(yōu)合成路線設計，基于反應機理與反應動力學研究的藥物合成工藝學習思想，貫徹并行培養(yǎng)專業(yè)思維與專業(yè)技能的教學理念

4 領銜或參與獲得多項學校一、二等與上海市一等教學獎項

對藥物與精細化學品合成工藝的貢獻

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1 迭代推進非活化溴代芳烴化合物甲氧基化、烷氧基化反應發(fā)展，發(fā)明第四代綠色定量甲氧基化反應工藝，實現(xiàn)直接回收精甲醇 

2 以氯化鋰/甲醇鈉體系代替有機鋰試劑作為“受阻型Claisen縮合”反應縮合劑，發(fā)明多取代、全取代吡唑藥效核合成方法，為藥物設計與合成提供有力工具

3 系統(tǒng)研究對甲酚、對烷基酚的氧化反應與機理，提出完整的Baik-Ji式樣的反應機理，為氧化手性合成奠定了基礎 

4 歷經(jīng)十幾年的認識與研究，在“前氧化”、“后氧化”路線的基礎上，發(fā)明以對甲酚、溴素為原料合成香蘭素的“中氧化”路線，為香蘭素生產(chǎn)工藝的更新?lián)Q代提供了可能

5 歷經(jīng)二十多年，在研究“單甲醚-雙甲醚”、“丙烯腈苯胺縮合物”工藝的基礎上，發(fā)明經(jīng)典原料藥甲氧芐啶第三代綠色生產(chǎn)工藝，推動傳統(tǒng)藥物生產(chǎn)工藝進步

6 基于C-H鍵活化，一步串聯(lián)反應精準構建復雜藥效核——多取代苯并噻吩并吡啶、苯并呋喃并吡啶、咔啉化合物

7 基于導向/無金屬活化，以三溴化硼為硼化試劑直接進行C-H鍵的親電硼化反應 

8 在研究“無溶劑法”、“異戊醇法”、“DMF-甲苯法”生產(chǎn)工藝基礎上，開發(fā)鹽酸二甲雙胍第四代綠色生產(chǎn)工藝，推動傳統(tǒng)藥物生產(chǎn)工藝進步

9 提出布洛芬、磺胺嘧啶等傳統(tǒng)藥物工藝革新思想，持續(xù)推動大品種原料藥綠色生產(chǎn)工藝進步

代表性論文
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Yu X, Liu X, Jin SK, Yin YZ, Liu YP, JI YF.* Electrochemical cascade reaction for C(sp3)-H tetrazolation of saturated heterocycles: access to tetrazole-5-thiones.  Org. Lett. 2026, 28, 1563?1568.  

Liu X, Yu X, Jin SK, Yin YZ, Hao LQ,* Ji YF.* Assembly of nitrated isoxazoles via a multicomponent cascade reaction using benzoxathiazine-2,2-dioxides as C1 synthons. Org. Lett. 2025, 27, 12801?12806. 

Jin SK, Liu X, Li CN, Yu X, Hao LQ,* Ji YF.* The cycloaddition reaction of N-homoallylacetohydrazides with O-benzoylhydroxylamines under copper catalysis: access to tetrahydropyridazine skeletons. Org. Lett. 2025, 27, 7597?7601. 

Liu X, Hao LQ, Yu X, Jin SK, Liu YP,* Ji YF.* Metal-free nitration/cyclization of unactivated olefins to access nitroated tetrahydropyridazines with sodium nitrate. Adv. Synth. Catal. 2025, 367, e202500290.  

Jin SK, Hao LQ, Li CN, Liu X, Yu Xiao, Mao JQ, Ding D,* Ji YF.* Copper-catalysed radical cascade reaction of N-substituted 2-pyridone-2-carboxaldehydes with styrenes access to 1,6-carboannulated 2-pyridone scaffolds. Org. Biomol. Chem. 2025, 23, 1814–1818.  

Yu X, Hao LQ, Liu X, Jin SK, Li YC, Liu YP*, Ji YF.* Electrochemical one-pot cascade synthesis of thio(seleno)cyanato-substituted thiazolidine-2-imines without external electrolyte. Org. Biomol. Chem. 2024, 22, 9366–9370.  

Yu X, Hao LQ, Liu X, Jin SK, Liu YP*, Ji YF.* Electrochemically induced desulfurization of thioureas for the synthesis of substituted 5-aminotetrazoles. Adv. Synth. Catal.  2024, 366, 3888–3893.   

Liu X, Hao LQ, Wang YY, Yu X, Yang ZZY, Liu YP,* Ji YF.* Cu₂O-catalyzed cascade phosphinylation/cyclization of 2'-aminochalcones for the synthesis of hemi-indigo derivatives. Org. Biomol. Chem. 2024, 22, 4249–4253.   

Xu XB, Yu X,Xia CC,*Ji YF.* Practical chemoselective aromatic substitution: highly efficient dinitrification of N-phenylbenzenesulfonamide for synthesis of N-(2,4- dinitrophenyl)benzenesulfonamide. Chin. J. Org. Chem. 2024, 44, 2915–2923. 

Xu XB, Hao LQ, Liu X, Wang YY, Yang ZZY, Ding D,* Ji YF.* Synthesia of fused-ring pyrrolizine derivatives via a Cu-catalyzed radical cascade cyclization. Synlett 2024, 35, 2236–2240.  

Xu XB, Wang YY, Yu Xiao, Liu X, Hao LQ, Ji YF.* Palladium-catalyzed (3+2) annulation of aromatic acids by C(sp3)?H olefination and decarboxylative cross-coupling reaction. Org. Lett. 2024, 26, 1338–1342.  

Hao LQ, Liu X, Yi DX, Wang YY, Yu Xiao, Ma ZH,* Ji YF.* The [3+2] cycloaddition reaction of N-substituted pyrrole-2-carboxaldehydes with arylalkenes under copper catalysis: access to dihydropyrrolizine skeletons. Org. Lett. 2023, 25, 9136–9141.  

Liu X, Hao LQ, Wang YY, Ji YF.* Synthesis of β-hydroxysulfides via multi-component cascade hydroxysulfenylation of styrenes with NH₄SCN and water under transition-metal-free conditions. Chem. Asian J. 2023, e202300901(2023-11-28 online).

Hao LQ, Wang ZC, Wang YY, Yang ZZ, Liu X, Xu XB, Ji YF.* Synthesis of pyrazoles from sulfonyl hydrazone and benzyl acrylate under transition-metal-free conditions. Org. Biomol. Chem. 2023, 21, 7611–7615. 

Yang ZZ, Hao LQ, Xu XB, Wang YY, Wu GR,* Ji YF.* C?H Borylation of benzophenones using hydrazone as the traceless directing group. Org. Lett. 2023, 25, 5875–5879. 

Wang YY, Liu X, Xu XB, Hao LQ, Ji YF.* Palladium-catalyzed tandem diolefination reaction of benzaldehyde enabled by a remote directing group. Org. Lett. 2023, 25, 4962–4967.  

Hao LQ, Wu GR, Wang YY, Xu XB, Ji YF.* Synthesis of C-3-functionalized imidazo[1,2-a]pyridines via direct para-position arylation of electron-rich anilines under transition-metal-free conditions. Adv. Synth. Catal. 2023, 365, 2159–2164. 

Hao LQ, Wu GR, Wang YY, Ji YF.* Synthesis of 1,4-benzoxazine derivatives from α-aminocarbonyls under transition-metal-free conditions. New Journal of Chemistry 2023, 47, 9527–9531. 

Pang BH, Wang YY, Hao LQ, Wu GR, Ma ZH,* Ji YF.* Tandem C–C/C–N bonds formation via Rh(III)-catalyzed α-fluoroalkenylation and sequential annulation of 2-arylquinazolinones and gem-difluorostyrenes. J. Org. Chem. 2023, 88, 143–153.

Xu XB, Wu GR, Yang ZZY, Liu X, Hao LQ, Wang YY, Ma ZH,* Ji YF.* Adamantane-1-carbonyl-directed C?H borylation and hydroxylation of benzenethiols. Org. Lett. 2022, 24, 7163–7167.   

Wang YY, Xu XB, Pang BH, Hao LQ, Wu GR, Ji YF.* Ligand-enabled sequential C(sp3)–H and C(sp2)–H diolefination reaction via palladium catalyst. Org. Lett. 2022, 24, 6734–6739. 

Wu GR, Yang ZZY, Xu XB, Hao LQ, Chen Lu, Wang YY, Ji YF.* Metal-free boron-mediated ortho-C-H hydroxylation of N?benzyl-3,4,5-tribromopyrazoles. Org. Lett. 2022, 24, 3570–3575.

Wang YY, Xu XB, Wu GR, Pang BH, Liao SW,* Ji YF.* Ligand-enabled C?H olefination and lactonization of benzoic acids and phenylacetic acids via palladium catalyst. Org. Lett. 2022, 24, 821–825.

Chen Lu, Wang ZC, Wang YY, Hao LQ, Xu XB, Wu GR,* Ji YF.* Rhodium(III)-catalyzed cascade C?H functionalization/annulation of sulfoximines with iodonium ylides for the synthesis of cyclohexanone-1,2- benzothiazines. Org. Biomol. Chem. 2022, 20, 887–894.

Wu GR, Xu XB, Wang S, Chen L, Pang BH, Ma T,* Ji YF.* Metal-free directed C?H borylation of 2-(N-methylanilino)-5-fluoropyridines and 2-benzyl-5-fluoropyridines. Chin. Chem. Lett. 2022, 33, 2005–2008. 

Chen L, Wang ZC, Pang BH, Wang YY, Xu XB, Wu GR, Ji YF.* Rhodium(III)-catalyzed cascade C?H activation/annulation of ncarbamoylindoles with silyl enol ethers for the construction of dihydropyrimidoindolone skeletons. Asian J. Org. Chem. 2021, 10, 2603–2610. 

Wang YY, Wu GR, Xu XB, Pang BH, Liao SW,* Ji YF.* Palladium-catalyzed β-C(sp³)–H arylation of aliphatic ketones enabled by a transient directing group. J. Org. Chem. 2021, 86, 7296–7303. 

Wu GR, Pang BH, Wang YY, Li Y,Chen L, Ma T,* Ji YF.* Metal-free ortho-selective C?H borylation of 2-phenylthiopyridines using BBr_3. J. Org. Chem. 2021, 86, 5933–5942. 

Tang SB, Fu XP, Wu GR, Zhang LL, Deng KZ, Yang JY, Xia CC,* Ji YF.* Rhodium(III)-catalyzed C4-amidation of indoleoximes with dioxazolones via C–H activation. Org. Biomol. Chem. 2020, 18, 7922–7931.

Zhang LL, Deng KZ, Wu GR, Yang JY, Tang SB, Fu XP, Xia CC,* Ji YF.* Ruthenium(II)-catalyzed α-fluoroalkenylation of oxime ethers with gem-difluorostyrenes via C–H activation and C–F cleavage. J. Org. Chem. 2020, 85, 12670–12681. 

Wu GR, Fu XP, Wang YY, Deng KZ, Zhang LL, Ma T,* Ji YF.* C?H Borylation of diphenylamines through adamantane-1-carbonyl auxiliary by BBr₃. Org. Lett. 2020, 22, 7003–7007.

Fu XP, Wang YY, Yang JY, Wu GR, Xia CC,* Ji YF.* Fully substituted pyrazoles assisted palladium-catalyzed late-stage arylation of C(sp2)-H bond. Chin. J. Org. Chem. 2020, 40, 4305–4314.

Fu XP, Chen L, Wu GR, Liu HW, Xia CC,* Ji YF.* Cascade access to carboline carboxylates from indolyl ketoximes and acrylates via palladium-catalyzed C–H bond alkenylation/annulation. Synlett 2021, 32, 69–74. 

Fu XP, Tang SB, Yang JY, Zhang LL, Xia CC, Ji YF.* Cascade reaction to synthesis of carbolines from O-methylketoximes and styrenes via palladium-catalyzed C–H bond activation and sequential annulation. Eur. J. Org. Chem. 2019, 5974–5977. 

Deng KZ, Zhang LL, Chen YF, Xie HX, Xu XB, Xia CC, Ji YF.* Copper-mediated direct thiolation of aryl C–H bonds with disulfides. Org. Biomo. Chem. 2019, 17, 7055–7065. 

Yang JY, Fu XP, Tang SB, Deng KZ, Zhang LL, Yang XJ, Ji YF.* 2-Amino-5,6- difluorophenyl-1H-pyrazole-directed Pd(II) catalysis: arylation of unactivated C(sp3)-H bonds. J. Org. Chem. 2019, 84, 10221–10236. 

Xing LH, Shao LY, Fu XP, Deng KZ, Yang JY, Ji YF.* Palladium-catalyzed thiazole-directed mono-selective C(sp2)-H bond iodination reaction. Chin. J. Org. Chem. 2019, 39, 3154–3161.  

Fu XP, Yang JY, Deng KZ, Shao LY, Xia CC,* Ji YF.* Tandem C–C/C–N formation via palladium-catalyzed C–H activation/styrenation and sequential annulation of O-methylketoxime with styrenes. Org. Lett. 2019, 21, 3505–3509.

Chen MM, Shao LY, Lun LJ, Wu YL, Fu XP, Ji YF.* Palladium-catalyzed late-stage mono-aroylation of the fully substituted pyrazoles via aromatic C–H bond activation. Chin. Chem. Lett. 2019, 30, 702–706. 

Shao LY, Li C, Guo Y, Yu KK, Zhao FY, Qiao WL, Liu HW, Liao DH, Ji YF*. Pd-catalyzed direct oxidative mono-aroyloxylation ofO-aralkyl substituted acetoxime ethers. RSC Advances, 2016, 6, 78875–78880. 

Yu, KK, Guo Y, Hu YH, Xu Z, Liu HW, Liao DH, Ji YF*. Pd-catalyzed diverse mono-acyloxylation of 5-alkyl-4-aryl-thiazole-2-carboxylates. Asian J. Org. Chem. 2016, 5, 219–1224.

Ding J, Guo Y, Shao LY, Zhao FY, Liao DH, Liu HW*, Ji YF*. Palladium-catalyzed multi-acetoxylation of 1,3-disubstituted 1H-pyrazole-5-carboxylatesvia direct C(sp²)?H or C(sp³)?H bond activation. Chin. Chem. Lett. 2016, 27, 1617–1621.

Fan XM, Guo Y, Li YD,Yu KK, Liu HW, Liao DH, Ji YF*. Pd-catalyzed late-stage mono-acetoxylation and mono-iodination of 4-alkyl-1,5-diaryl-1H-pyrazole-3-carboxylates via direct Csp2-H bond activation. Asian J. Org. Chem. 2016, 5, 499–505. 

Zhang ZN, Huang JG, Zhai JJ, Guo Y, Ji YF*. Copper(II)-catalyzed oxidative esterification of substituted p-cresols under ligand- and additive-free conditions. Synlett 2015, 26, 2145–2150. 

Guo Y, Li YD, Chen C, Zhao JH, Liu HW, Liao DH, Ji YF*. A practical ligand-free copper(I) bromide-catalyzed fluoroalkoxylation of unactivated aryl bromides. Res. Chem. Intermediat. 2016, 42, 2525–2537. 

Huang JG, Guo Y, Li YD, Liu HW,* Liao DH, Ji YF*. Undecorated Cu(OAc)2-catalyzed C(sp3)–C(sp3) bond formation through a para-hydroxyl group-triggered remote benzylic C(sp3)–H bond functionalization. Eur. J. Org. Chem. 2015, 5334–5338.   

Guo Y, Fan XM, Nie M, Liu HW, Liao DH, Pan XD,* Ji YF*. Practical ligand-free Cu-catalyzed short-chain alkoxylation of unactivated aryl bromides. Eur. J. Org. Chem. 2015, 4744–4755.

Guo Y, Chen C, Liu HW,* Zhao JH, Zheng, YL, Ji YF*. A ligand-free, powerful and practical method for methoxylation of unactivated aryl bromides by use of CuCl/HCOOMe/MeONa/MeOH system. Res. Chem. Intermediat. 2015, 41, 8651–8664.

Zhai JJ, Gu CH, Guo Y, Liao DH, Zhu DR, Ji YF*. One-pot synthesis of highly substituted 1H-pyrazole-5-carboxylates from 4-aryl-2,4-diketoesters and arylhydrazines. J. Heterocyclic Chem. 2016, 53, 840–848.

Huang JG, Guo Y, Jiang JA, Liu HW, Ji YF*. An eco-friendly Co(OAc)2-catalyzed aerobic oxidation of 4-benzylphenols into 4-hydroxybenzophenones. Res. Chem. Intermediat. 2015, 41, 7115–7124.

Jiang JA, Chen C, Guo Y, Liao DH, Pan XD, Ji YF*. A highly efficient approach to vanillin starting from 4-cresol. Green Chem. 2014,16, 2807–2814. 

Gu CH, Zhai JJ, Jiang JA, Liu HW, Wang L, Zhu DR, Ji YF*. An efficient one-pot synthesis of aryl-substituted 1-(thiazol-2-yl)-1H-pyrazole-3-carboxylates via a Hantzsch synthesis-Knorr reaction sequence. Chin. J. Chem. 2014, 32, 179–190. 

Jiang JA, Chen C, Huang JG, Liu HW, Cao S, Ji YF*. Cu(OAc)₂-catalyzed remote benzylic C(sp3)–H oxyfunctionalization for C=O formation directed by the hindered para-hydroxyl group with ambient air as terminal oxidant under ligand- and additive-free conditions. Green Chem. 2014, 16, 1248–1254.  

Jiang JA, Du JL, Liao DH, Wang ZG, Ji YF*. Efficient Co(OAc)₂-catalyzed aerobic oxidation of EWG-substituted 4-cresols to access 4-hydroxybenzaldehydes. Tetrahedron Lett. 2014,5 5, 1406–1411.  

Zhai  JJ, Gu CH, Jiang JA, Zhang SL, Liao DH, Wang L, Zhu DR, Ji YF*. A one- pot approach to ethyl 1,4,5-triaryl-1H-pyrazole-3-carboxylates via an improved Claisen condensation-Knorr reaction sequence. Chin. J. Chem. 2013,31, 1526–1538.   

Jiang JA, Du JL, Zhang ZN, Zhai JJ, Ji YF*. An environmentally friendly and highly efficient Co(OAc)₂-catalyzed aerobic oxidation to access 2,6-di-electron-donating group substituted 4-hydroxybenzaldehydes. Syn. Commun. 2014,44, 1430–1440.      

Zhai JJ, Jiang JA, Zhang SL, Chen C, Liu HW, Liao DW, Ji YF*. Stereoselective or exclusive synthesis of ethylZ-2-(2-substituted-thiazol-4-yl)pent-2-enoates from ethylE/Z-2-(2-bromoacetyl)pent-2-enoate. Synlett 2013, 24, 1399–1404.   

Huang WB, Guo Y, Jiang JA, Pan XD, Liao DH, Ji YF*. An efficient strategy for protecting dihydroxyl groups of catechols. Synlett 2013,24, 741–746.

Jiang JA, Huang WB, Zhai JJ, Liu HW, Cai Q, Xu LX, Wang W, Ji YF*. “One-pot” synthesis of 4-substituted 1,5-diaryl-1H-pyrazole-3-carboxylates via lithiumtert-butoxide-mediated sterically hindered Claisen condensation and Knorr reaction. Tetrahedron 2013, 69, 627–635.

Jiang JA, Ji YF*.  Alternative synthesis of apixaban (BMS-562247), an inhibitor of blood coagulation factor Xa.Syn. Commun. 2013, 43, 72–79.

Jiang JA, Du CY, Gu CH, Ji YF*. “One-pot” synthesis of 4-substituted 1,5-diaryl-1H-pyrazole-3- carboxylic acids via a MeONa/LiCl-mediated sterically hindered Claisen condensation-Knorr reaction-hydrolysis sequence. Synlett 2012, 23, 2965–2968.   

Huang WB, Du CY, Jiang JA, Ji YF*. Concurrent synthesis of vanillin and isovanillin. Res. Chem. Intermediat. 2013, 39, 2849–2856. 

Ji YF*, Jiang JA, Liu HW, Liao DH, Wei XY. Practical preparation of trimethoprim: a classical antibacterial agent. Syn. Commun. 2013, 43, 1517–1522.

授權專利

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衛(wèi)潔，劉倩，丁濤，王樹華，冀亞飛.一種制備質子泵抑制劑硫醚中間體的方法.中國發(fā)明授權專利號：ZL2012102112430，申請日：2012-06-26.

冀亞飛，張鵬志，萬歡，段梅莉，許煦，王毅. 一種5-(4-氯苯基)-1-(2,4二氯苯基)-4-甲基吡唑-3-甲酸酯的制備方法. 中國發(fā)明授權專利號：ZL200810038071.5，申請日：2008-05-23.