高峰 教授，博導(dǎo)
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電話: 021-6425-2449
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傳真:
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E-mail: fgao@ecust.edu.cn
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個(gè)人簡(jiǎn)介
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2001年日本國(guó)立千葉大學(xué)藥學(xué)院獲藥學(xué)博士學(xué)位，2001－2002.3在日本千葉大學(xué)藥學(xué)院作博士后，從事抗腫瘤藥物與內(nèi)源性氧自由基的關(guān)系，及其所引起消化管毒性機(jī)制的研究工作。2002－2004.3在日本國(guó)立大阪大學(xué)微生物病研究所進(jìn)行博士后研究，從事抗腸道傳染病功能高分子微球－抗體復(fù)合體制劑的研究工作。2004年5月受聘于華東理工大藥學(xué)院，副教授，教授。現(xiàn)任藥物制劑專(zhuān)業(yè)責(zé)任教授。主要研究方向?yàn)榉肿由锼巹W(xué)和毒理學(xué)。先后承擔(dān)了“上海市引進(jìn)海外高層次留學(xué)人員專(zhuān)項(xiàng)資金”等科研項(xiàng)目10項(xiàng)。曾獲得美國(guó)FIP頒布的“優(yōu)秀研究論文”、日本藥學(xué)會(huì)頒布的“長(zhǎng)井優(yōu)秀論文”、“第四屆藥物制劑論壇”優(yōu)秀青年報(bào)告獎(jiǎng)等多項(xiàng)國(guó)際學(xué)會(huì)獎(jiǎng)項(xiàng)。發(fā)表學(xué)術(shù)論文70余篇，申請(qǐng)專(zhuān)利6項(xiàng)，其中2項(xiàng)授權(quán)。
研究方向
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現(xiàn)主要研究領(lǐng)域：
分子生物藥劑學(xué)研究、毒理學(xué)研究
現(xiàn)主要研究方向：
1、新型微粒給藥系統(tǒng)的構(gòu)建及體內(nèi)外功效評(píng)價(jià)
2、多尺度納米顆粒生物安全性評(píng)價(jià)體系研究
3、藥物制劑開(kāi)發(fā)與藥物動(dòng)力學(xué)研究
獲獎(jiǎng)成果
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1）在2001年日本薬剤學(xué)會(huì)第16年會(huì)學(xué)會(huì)中榮獲日本藥學(xué)會(huì)頒布的“長(zhǎng)井優(yōu)秀論文獎(jiǎng)”
2）在2000年世界藥學(xué)學(xué)會(huì)中榮獲有美國(guó)FIP頒布的“優(yōu)秀研究論文獎(jiǎng)”
3）在2009年第四屆國(guó)際藥物制劑論壇中榮獲“青年報(bào)告獎(jiǎng)”
代表性論著
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1. Yuan ZT, Ye YJ, Gao F*, Yuan HH, Lan MB, Lou KY, Wang W. Chitosan-graft-β-cyclodextrin nanoparticles as a carrier for controlled drug release. Int J Pharm. 2013, 446: 191-198.
2. 陳水娟, 付棟君, 高姍姍, 高峰*, 左建平. 難溶性藥物BMCP25 二甲基-β- 環(huán)糊精包合物的表征及在大鼠體內(nèi)的藥動(dòng)學(xué). 中國(guó)醫(yī)藥工業(yè)雜志. 2013, 44 (2): 171-174.
3. 陳香, 姚芳, 陳水娟, 方源, 高峰*, 鐘建江. 靈芝酸單體 T 片劑的制備及其兔體內(nèi)藥動(dòng)學(xué)研究. 中國(guó)藥學(xué)雜志. DOI: 10. 11669/ cpj. 2013. 12.00?
4. Gao SS, Sun J, Fu DJ, Zhao HL, Lan MB, Gao F*. Preparation, characterization and pharmacokinetic studies of tacrolimus-dimethyl-β-cyclodextrin inclusion complex-loaded albumin nanoparticles. Int J Pharm. 2012, 427: 410-416.
5. Shen Q,Gao SS, Gao F*. Curative effect of novel oral carbon microspheres on streptozotocin induced diabetes mellitus in rats. J Chin Pharm Sci. 2012, 21: 234-241.
6. Wang F, Gao F*. Oxidative mechanisms contribute to nanosize silican dioxide-induced developmental neurotoxicity in PC12 cells. Toxicol In Vitro. 2011, 25: 1548-1556.
7. Xie YN, Gao F*. Preparation of a novel activated carbon microsphere and its in vitro adsorption characteristics for biological molecules. J Chin Pharm Sci. 2011, 20: 303-308.
8. Jiang ZJ, Jin TT, Gao F, Liu JW *,Zhong* JJ, Zhao H*. Effects of ganoderic acid Me on inhibiting multidrug resistance and inducing apoptosis in multidrug resistant colon cancer cells. Process Biochem, 2011, 46: 1307-1314.
9. 高原, 蔡軼軍, 高峰*.硫酸氫氯吡格雷片處方和制備工藝研究. 中國(guó)藥學(xué)雜志, 2011, 46(2): 117-123.
10. 陶少林, 陳香, 鐘建江, 高峰*. 靈芝酸單體Me腸溶膠囊制備及其兔體內(nèi)生物利用度測(cè)定. 中成藥. 2011, 33 (6): 950-954.
11. Sun Y, Gu L, Gao Y, Gao F*.Preparation and characterization of 5-fluorouracil loaded chitosan microspheres by a two-step solidification method. Chem Pharm Bull. 2010, 58: 891-895.
12. Chen X, Tao SL, Gao F*, Zhong JJ. Quantitative determination of ganoderic acid T in rat plasma by a sensitive RP-HPLC method and its pharmacokinetic studies. J Chin Pharm Sci. 2010, 19: 171-175.
13. 楊春梅, 顧磊, 孫怡, 施竟成, 樂(lè)子娜, 高峰*. 離子交聯(lián)法制備氟尿嘧啶殼聚糖微球的研究. 華東理工大學(xué)學(xué)報(bào). 2010, 36: 546-549.
14. 楊春梅, 顧磊, 孫怡, 孫軍, 高峰*. 戊二醛一步固化法制備5-氟尿嘧啶殼聚糖微球制劑的研究.中國(guó)醫(yī)藥工業(yè)雜志. 2010, 41(1): 23-26.
15. Xu K, Liang X, Gao F, Zhong JJ, Liu JW. Antimetastatic effect of ganoderic acid T in vitro through inhibition of cancer cell invasion. Process Biochem. 2010, 45: 1261-1267.
16. Yuan HH, Gao F, Zhang ZG, Miao LD, Yu RH, Zhao HL, Lan MB. Study on controllable preparation of silica nanoparticles with multi-sizes and their size-dependent cytotoxicity in pheochromocytoma cells and human embryonic kidney cells. J Health Sci. 2010, 56: 632-640.
17. Zhao HL, Zhang JF, Gao F, Lan MB. Synthesis, spectral properties and cell assays of novel fluorophore-modified-β-cyclodextrin derivatives. Adv Sci Lett. 2010, 3: 1-6.
18. Lan MB, Zhang YH, Zheng Y, Yuan HH, Zhao HL, Gao F. Antioxidant and immunomodulatory activities of polysaccharides from moxa (Artemisia argyi) leaf. Food Sci Biotechnol. 2010, 19: 1463-1469.
19. Wang F, Gao F*, Lan MB, Yuan HH, Huang YP, Liu JW. Oxidative stress contributes to silica
nanoparticle-induced cytotoxicity in human embryonic kidney cells. Toxicol In Vitro. 2009, 23: 808-815.
20. 陶少林, 鐘建江, 高峰*.高效液相色譜法測(cè)定大鼠全血中的靈芝酸單體Me. 現(xiàn)代儀器. 2009, 15(1):26-28.
21. 李艾斯,黃永平, 劉建文, 藍(lán)閩波, 高峰. 藥用納米SiO2 對(duì)人正常肺細(xì)胞的氧化損傷. 中國(guó)臨床藥理學(xué)與治療學(xué). 2009, 14(10), 1115-1120.
22. Gao F, Kodama T, Chen XH, Okada K, Honda K. A targeting approach for delivery of polymer microparticle-antibody conjugate against Vibrio parahaemolyticus - induced cytotoxicity to human intestinal epithelial cells. J Drug Target. 2007, 15 (6): 428-36.
23. 萬(wàn)曉璐, 王蘇莉, 高峰, 崔景斌. 避蚊胺緩釋霜?jiǎng)┑难兄萍捌潴w外的經(jīng)皮滲透.華西藥學(xué)雜志. 2007, 22(2), 174-176.
24. 陶一丹, 謝毅妮, 騰娜, 高峰. 新型口服活性炭微球?qū)?nèi)源性分子肌酐的吸附性能研究. 廣州化工. 2007, 35(5), 32-35.
25. Ren F, Jing Q, Tang Y, Shen Y, Chen J, Gao F, Cui J. Characterization of bicalutamide solid dispersions and improvement of the dissolution. Drug Dev Ind Pharm. 2006, 32(8): 967-72.
26. Miyazono Y, Gao F, Horie T. Oxidative stress contributes to methotrexate-induced small intestinal toxicity in rats. Scand J Gastroenterol. 2004, 39: 1119-27.
27. Sosogi A, Gao F, Tomimatsu T, Hirata K, Horie T. Non-steroidal anti-inflammatory drugs affect the methotrexate transport in IEC-6 cells. Life Sci. 2003, 73 (4): 437-46.
28. Sosogi A, Gao F, Tomimatsu T, Hirata K, Horie T. Effects of non-steroidal anti- inflammatory drugs on the methotrexate transport in rat small intestine. Scand J Gastroenterol. 2003, 38(1):43-9.
29. Gao F, Tomitori H, Igarashi K, Horie T. Correlation between methotrexate-induced intestinal damage and decrease in polyamine content. Life Sci. 2002, 72 (6): 669-76.
30. Gao F, Horie T. A synthetic analog of prostaglandin E(1) prevents the production of reactive oxygen species in the intestinal mucosa of methotrexate-treated rats. Life Sci. 2002, 71(9):1091-9.
31. Gao F, Nakamaru M, Masubuchi Y, Horie T. Protective effect of a synthetic analog of prostaglandin E(1) on the small intestinal damage induced by the administration of methotrexate to rats. J Pharm Sci. 2001, 90(8):1040-8.
32. Gao F, Ueda S, Horie T. Effect of a synthetic analog of prostaglandin E1 on the intestinal mucosa of methotrexate-treated rats. Anticancer Res. 2001, 21 (3B):1913-7.
33. Gao F, Horie T. Protective effect of prostaglandins on the methotrexate induced damage of small intestine in rats.
In Vivo. 2000, 14(3):453-6.
發(fā)明專(zhuān)利
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1. 高峰, 孫怡, 藍(lán)閔波, 趙紅莉, 曹海, 付棟君. 一種腦靶向基頭修飾性環(huán)糊精衍生物的合成方法. 中國(guó)專(zhuān)利: 201010266055.9, 2010-08-25.
2. 高峰, 鐘建江, 陶少林, 謝旖旎, 王芬, 孫軍, 孫怡, 陳香,李英波, 王家樂(lè). 靈芝酸單體Me環(huán)糊精包合物及其口服固體制劑的制備方法. 中國(guó)專(zhuān)利: 200910050801.8, 2009-05-08.
3. 高峰, 等. 一種靈芝酸單體T片劑及其制備方法. 中國(guó)專(zhuān)利: 201010501013.9.
4. 高峰, 等. 一種二氧化硅納米顆粒細(xì)胞生物安全性的評(píng)價(jià)方法. 中國(guó)專(zhuān)利: 200910196617.4
5. 杜一平, 高峰, 等. 一種直接植入式微透析探針及其制備方法. 中國(guó)專(zhuān)利: 200910195763.5.
6. 藍(lán)閔波, 高峰, 等. 艾葉多糖的臨床前研究. 中國(guó)專(zhuān)利: 08DZ1974000.
